Navigation Links
Liver fibrosis will be treated by a potential target
Date:10/16/2007

The outcome of hepatitis is either self recovery or its development into liver fibrosis or, further, liver cirrhosis. Liver fibrosis is the early pathological process of cirrhosis, which is considered a reversible, wound-healing response. Since no ideal drug is available for its therapy, liver fibrosis is currently considered to be a major worldwide health problem.

Previous studies have demonstrated that activin A is involved in hepatic fibrosis formation. However, the mechanism of the fibrotic process is not well understood. Activin receptor-interacting protein 2 (ARIP2) has been recently identified as a negative regulator of activin signal pathways. The fact that ARIP2 is highly expressed in the liver suggests that ARIP2 may participate in activin-induced anti-fibrosis in the liver.

A research article published on November 7 in the World Journal of Gastroenterology addresses this question. A research team led by Dr. ZH Liu from Jilin University spent more than five years researching ARIP2. The researchers used mouse Hepal-6 cells obtained from mouse a hepatoma cell line that had functions of hepatic parenchymal cells to investigate the effects of ARIP2 anti-fibrosis on the production of collagen type IV, which is a component of the extracellular matrix (ECM) in liver fibrosis.

One conclusion reported by the investigators is that the mode of expression regulation by various activators of signaling transduction, such as PMA, foskolin and LPS, has been characterized, and its negative effect on the production of collagen type IV revealed, using Hepal-6 cells.

An additional result was that the expression level of ARIP2 mRNA in the Hapel-6 cells was elevated 12 h after treatment with activin A and endotoxin LPS. Thus, it was concluded that ARIP2 participates in the negative feedback regulation of signal transduction in the late stage by affecting the expression of ActRIIA, which further suggests that ARIP2 might be a potential target for treatment
'/>"/>

Contact: You-De Chang
y.d.chang@wjgnet.com
0086-108-538-1892
World Journal of Gastroenterology
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Blood Cells Capable of Regenerating Liver
2. Laboratory Testing Can Identify Risk of Pre-Term Labor and Delivery
3. Infant receives first bloodless liver transplant
4. Liver donors can thrive after transplant
5. Antibiotic induces liver damage in children with E.COLI infections.
6. The Effects Of Delaying A Delivery Questioned
7. Baby Lennox Gets Liver Transplant
8. Milk Thistle Not An Effective Cure For Liver Disease
9. Metronidazole Increases Risk Of Premature Deliveries.
10. Early delivery can prevent cancer
11. A new treatment for liver cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2013)... Pomona, NY (PRWEB) May 18, 2013 Dr. ... sleep apnea dentistry, employs his knowledge of the ... in sleep apnea patients. With May being Better Sleep Month, ... have some sort of chronic sleep disorder, and sleep apnea ... With sleep apnea, a person will essentially stop breathing at ...
(Date:5/18/2013)... May 18, 2013 John Ravera, D.D.S., a ... addition of a new member to his dental team, Courtney ... in the field for over 10 years. She received her ... and was elected a member of Sigma Pi Alpha, a ... Marino enjoys working with patients of all ages, helping them ...
(Date:5/18/2013)... 2013 According to the the Stevens Johnson ... Epidermal Necrolysis, is a severe allergic reaction usually to medicine ... but it can quickly advance causing blistering and large areas ... death. SJS can develop at any time and seriously ... NBA player, Manute Bol, passed away after he received kidney ...
(Date:5/18/2013)... The product liability attorneys at Wright & Schulte have ... nationwide who have sustained serious tendon injuries allegedly caused by ... all part of MDL 2308 and were all filed on ... heard in the U.S. District Court of the Western District ... specializes in defending the rights of those who have suffered ...
(Date:5/17/2013)... (PRWEB) May 17, 2013 Daily Gossip announced ... with the creator of the Program Yourself Thin ... on their online website by the end of the month ... accomplish to successfully reeducate themselves and lead a healthy lifestyle, ... Program Yourself Thin package is available for only $97 ...
Breaking Medicine News(10 mins):Health News:Pomona, NY Dentist, Dr. Robert Tracey of General & Laser Assisted Dentistry (GLAD) Highlights Sleep Apnea Dentistry Services for Better Sleep Month 2Health News:Pomona, NY Dentist, Dr. Robert Tracey of General & Laser Assisted Dentistry (GLAD) Highlights Sleep Apnea Dentistry Services for Better Sleep Month 3Health News:Newport Beach Cosmetic Dentist John Ravera Adds New Member to Dental Team 2Health News:Injury Law Firm Announces New Informative Graphic on Common Medicines That Have Allegedly Been Linked to Stevens Johnson Syndrome 2Health News:Ten Skechers Lawsuits Filed by Wright & Schulte on Behalf of Consumers Who Sustained Severe Tendon Damage Allegedly Due to Wearing Skechers Shape-Ups 2Health News:Ten Skechers Lawsuits Filed by Wright & Schulte on Behalf of Consumers Who Sustained Severe Tendon Damage Allegedly Due to Wearing Skechers Shape-Ups 3Health News:Ten Skechers Lawsuits Filed by Wright & Schulte on Behalf of Consumers Who Sustained Severe Tendon Damage Allegedly Due to Wearing Skechers Shape-Ups 4Health News:Program Yourself Thin Review and Secrets Revealed By Daily Gossip Magazine 2
... its key inflammatory mediators (IL-12 and IL-23) is highly ... researchers. ,Current treatments for psoriasis include ... symptoms of the disease. Many of these treatments are ... very effective, according to Gerald Krueger, M.D., principal investigator ...
... extreme losses -- in two cases, greater than $100,000 -- ... been linked to a class of drugs commonly used to ... Mayo Clinic study is the first to describe this compulsive ... that stimulate dopamine receptors in the brain. ,The ...
... A botched up family planning operation would have claimed one ... of Indian origin// wasn't there to perform a lifesaving surgery. ... 300 km from here, was a boon for Vijayanti Devi, ... was cut out by mistake during a routine family planning ...
... set to start its manufacturing facility in the ... drug market. ,Ind-Swift Laboratories has completed ... its Clarithromycin active pharmaceutical ingredient (API) manufacturing unit, ... ,Clarithromycin is a macrolide antibiotic molecule ...
... diagnosis laboratories and counselling centres in various hospitals as HIV ... ,The decision was announced at the second meeting of the ... UNB reported. ,The meeting, chaired by health advisor ... policy, said a press release. ,The meeting decided ...
... of diseases or disorders of the valves in the heart ... caused by diseases such as rheumatic fever, or degenerative// conditions ... for valvular heart disease (VHD) highlight the need for improvement ... chair of the European Society of Cardiology (ESC) task force ...
Cached Medicine News:Health News:New Treatment For Psoriasis Is Highly Effective 2Health News:Medications for Restless Legs Syndrome may Trigger Compulsive Gambling 2Health News:Medications for Restless Legs Syndrome may Trigger Compulsive Gambling 3Health News:New Guidelines for VHD 2Health News:New Guidelines for VHD 3Health News:New Guidelines for VHD 4
(Date:5/17/2013)... -- Fuse Science, Inc. (OTCQB: DROP), ( www.fusescience.com ) a ... patent-pending technologies poised to redefine how consumers receive energy, medicines, ... business update teleconference and webcast for shareholders and the investment ... PM ET. Fuse Science, Inc. CEO, ... will be joined by Rubin Hanan , ...
(Date:5/17/2013)... , May 17, 2013  Atossa Genetics, Inc. (NASDAQ: ... that Kyle Guse , Chief Financial Officer ... LLP MicroCap Conference on Thursday, May 30, 2013, in ... Hotel. The Company,s presentation is scheduled to ... a live webcast. To access the webcast, go to ...
(Date:5/17/2013)... BEIJING , May 17, 2013 Sinovac Biotech ... vaccines in China , today announced that ... quarter ended March 31, 2013, before market on Tuesday, May ... Tuesday, May 28, 2013, at 8:00 a.m. EDT (May 28, ... Company,s financial results and provide an update on recent corporate ...
Breaking Medicine Technology:Fuse Science, Inc. to Hold Business Update Webcast and Teleconference on May 22nd 2Atossa Genetics to Present at the Second Annual Marcum LLP MicroCap Conference 2Atossa Genetics to Present at the Second Annual Marcum LLP MicroCap Conference 3Sinovac to Host Conference Call to Report First Quarter 2013 Unaudited Financial Results 2Sinovac to Host Conference Call to Report First Quarter 2013 Unaudited Financial Results 3
... to be Dosed Shortly -, SAN DIEGO, March ... completion of the safety and,tolerability assessment of its third ... new HspE7 (HspE7 + Poly-ICLC) in patients with cervical,intraepithelial ... and met the limits prescribed in the trial protocol, ...
... will remain open until March 21, 2008, ... as,government agencies when implementing new policies, a national ... today,called for public comment on a series of ... trials., As part of the four year ...
Cached Medicine Technology:Nventa Evaluation Complete for First Three Cohorts in HspE7 Phase 1 Cervical Dysplasia Trial 2Nventa Evaluation Complete for First Three Cohorts in HspE7 Phase 1 Cervical Dysplasia Trial 3Nventa Evaluation Complete for First Three Cohorts in HspE7 Phase 1 Cervical Dysplasia Trial 4Nventa Evaluation Complete for First Three Cohorts in HspE7 Phase 1 Cervical Dysplasia Trial 5EDICT Opens Public Comment Period for Clinical Trials Policy Recommendations 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: