Navigation Links
Liver fibrosis will be treated by a potential target
Date:10/16/2007

The outcome of hepatitis is either self recovery or its development into liver fibrosis or, further, liver cirrhosis. Liver fibrosis is the early pathological process of cirrhosis, which is considered a reversible, wound-healing response. Since no ideal drug is available for its therapy, liver fibrosis is currently considered to be a major worldwide health problem.

Previous studies have demonstrated that activin A is involved in hepatic fibrosis formation. However, the mechanism of the fibrotic process is not well understood. Activin receptor-interacting protein 2 (ARIP2) has been recently identified as a negative regulator of activin signal pathways. The fact that ARIP2 is highly expressed in the liver suggests that ARIP2 may participate in activin-induced anti-fibrosis in the liver.

A research article published on November 7 in the World Journal of Gastroenterology addresses this question. A research team led by Dr. ZH Liu from Jilin University spent more than five years researching ARIP2. The researchers used mouse Hepal-6 cells obtained from mouse a hepatoma cell line that had functions of hepatic parenchymal cells to investigate the effects of ARIP2 anti-fibrosis on the production of collagen type IV, which is a component of the extracellular matrix (ECM) in liver fibrosis.

One conclusion reported by the investigators is that the mode of expression regulation by various activators of signaling transduction, such as PMA, foskolin and LPS, has been characterized, and its negative effect on the production of collagen type IV revealed, using Hepal-6 cells.

An additional result was that the expression level of ARIP2 mRNA in the Hapel-6 cells was elevated 12 h after treatment with activin A and endotoxin LPS. Thus, it was concluded that ARIP2 participates in the negative feedback regulation of signal transduction in the late stage by affecting the expression of ActRIIA, which further suggests that ARIP2 might be a potential target for treatment of liver fibrosis induced by activin.


'/>"/>

Contact: You-De Chang
y.d.chang@wjgnet.com
0086-108-538-1892
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Blood Cells Capable of Regenerating Liver
2. Laboratory Testing Can Identify Risk of Pre-Term Labor and Delivery
3. Infant receives first bloodless liver transplant
4. Liver donors can thrive after transplant
5. Antibiotic induces liver damage in children with E.COLI infections.
6. The Effects Of Delaying A Delivery Questioned
7. Baby Lennox Gets Liver Transplant
8. Milk Thistle Not An Effective Cure For Liver Disease
9. Metronidazole Increases Risk Of Premature Deliveries.
10. Early delivery can prevent cancer
11. A new treatment for liver cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... December 07, 2016 , ... ... announce that its fully redesigned website, which launched October 17, 2016, features comprehensive ... responsive design and easy-to-navigate layout. Visitors and patients can discover the latest clinical ...
(Date:12/7/2016)... ... 07, 2016 , ... 1105 Media’s Live From program has ... Awards competition. Live From won in the Use of Social Media category. The ... projects undertaken by the media industry’s most innovative marketing professionals. , ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... portable bioelectronic medicine device WellnessPro Plus for consumers and healthcare professionals to ... WellnessPro platform by expanding the treatment modalities available in a single device. ...
(Date:12/7/2016)... ... ... “Walking With God: Inspirational Lessons from My Life's Journey”: a sometimes serious, sometimes ... direction in their lives. “Walking With God: Inspirational Lessons from My Life's Journey” is ... , Sanford says, “I enjoy sharing the true stories in my book as ...
(Date:12/7/2016)... ... December 07, 2016 , ... Dr. Greg Leyer, the ... Probiotic Association’s Washington DC workshop on November 2nd. The conference was an opportunity ... probiotic dietary supplement regulations. , Dr. Leyer spoke about two main topics ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)... Calif. , Dec. 6, 2016 /PRNewswire/ ... held, clinical-stage medical dermatology and aesthetics company, ... a privately held specialty pharmaceutical company focused ... inflammatory skin conditions, including psoriasis, atopic dermatitis ... the agreement, Sienna will make an undisclosed ...
(Date:12/6/2016)... Mass. , Dec. 6, 2016  Blueprint Medicines ... discovering and developing targeted kinase medicines for patients with ... an underwritten public offering of $125,000,000 million in shares ... to grant the underwriters a 30-day option to purchase ... of its common stock in connection with the public ...
(Date:12/6/2016)... Dec. 6, 2016  In response to the tragic ... every 25 minutes, a respected group of local and ... provide a holistic suite of services to help Medicaid-eligible ... on his own experience trying to help family and ... Justin Lanning launched 180 Health Partners ...
Breaking Medicine Technology: