Navigation Links
Liver Cancer Drug Raises Blood Pressure

Patients taking Nexavar need to be monitored closely, study says

TUESDAY, Jan. 22 (HealthDay News) -- A drug that prolongs the lives of patients with kidney or liver cancer also increases the risk of developing high blood pressure.

Patients taking Nexavar (sorafenib) need to be carefully monitored and treated, said the authors of a study appearing in the Jan. 22 online issue of Lancet Oncology.

Nexavar is an anti-angiogenesis drug, meaning it fights cancer by cutting off a tumor's blood supply.

It was approved in 2005 to treat advanced kidney cancer and in 2007 to treat the most common form of liver cancer that can't be surgically removed (unresectable hepatocellular carcinoma or HCC).

In clinical testing, Nexavar improved overall survival by 44 percent among people with HCC. Median overall survival was 10.7 months among those treated with the drug, versus 7.9 months among those who took a placebo. This was considered a major inroad against one of the most voracious cancers.

Nexavar is also being assessed to treat small-cell lung cancer, prostate cancer and melanoma.

Earlier trials, however, had shown a 16 percent to 42.6 percent incidence of hypertension in patients taking the drug. If not properly controlled, hypertension can lead to strokes and heart attacks, as well as kidney failure.

For this paper, researchers at the State University of New York Stony Brook conducted a meta-analysis of published clinical trials on Nexavar.

In all, nine studies involving 4,599 patients published between January 2006 and July 2007 were analyzed.

There was a 23.4 percent incidence of all-grade hypertension, and a 5.7 percent incidence of high-grade hypertension.

This is not the first time hypertension has been associated with an angiogenesis inhibitor. Several other drugs in this category, including Avastin (bevacizumab) and Sutent (sunitinib), have also raised blood pressure in patients.

More information

Visit the American Cancer Society for more on liver cancer.

-- Amanda Gardner

SOURCE: Lancet Oncology, news release, Jan. 21, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Struggling Medical Delivery System Impacts Hospitals and Physicians Hardest
2. Indian medicinal plant Acanthus ilicifolius may combat liver cancer
3. An emerging candidate for protecting patients from liver injury after abdomen surgery
4. March of Dimes Delivers a New Look
5. Engaging 2008 Debate, Key Long Term Care Advocacy Groups Offer New Plan to Strengthen Nations Long Term and Post-Acute Care Delivery System
6. Tri-State Hospital to Gain Greater Efficiency and Responsiveness in Delivering Patient Care with Siemens Open Communications Solutions
7. Proteomic profiling shown more accurate than traditional biomarkers in identifying liver cancer
8. Independence Blue Cross Delivers Important Reminder to Women during Cervical Cancer Awareness Month
9. EHE International Supports the American Liver Foundations Efforts at Raising Awareness for Hepatitis
10. High-energy ultrasound sharpens view of liver tumors
11. Treatment with NAC is associated with better outcomes for children with liver failure
Post Your Comments:
Related Image:
Liver Cancer Drug Raises Blood Pressure
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual ... in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon ... fun run is geared towards children of all ages; it is a non-competitive, non-timed ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... viewers the lowdown on sciatica in a new episode of "Success Files," which ... current events and innovation and investigates each subject in-depth with passion and integrity. ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to ... to save lost souls in the Philippines. “The Journey: From the Mountains to the ... teacher of the Bible. She has taught all ages and currently teaches a class ...
(Date:10/12/2017)... ... 2017 , ... First Healthcare Compliance (FHC), an industry leader ... range of technology and learning solutions at the 68th Annual American Healthcare Association ... held October 14–18, 2017 at the Mandalay Bay Resort in Las Vegas, Nevada. ...
(Date:10/12/2017)... ... 2017 , ... Planet Fitness, one of the largest and fastest growing franchisors ... a flagship location in Covington, LA at 401 N. U.S. Highway 190, in January ... Office Depot in the Holiday Square shopping center. Its location allows it to serve ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... DIEGO , Oct. 12, 2017 AVACEN ... recognized the company with their  2017 New Product Innovation Award ... based on extensive primary and secondary medical device market research ... Medical, through its first-to-market OTC, drug-free pain relief product, the ... unique approach to treating fibromyalgia widespread pain. ...
(Date:10/11/2017)... Calif. , Oct. 11, 2017  BioPharmX Corporation ... scientific team that developed an innovative way to use ... of the delivery of new drugs. ... Fall Clinical Dermatology Conference will show how researchers from ... Hospital, Harvard Medical School used a suite of imaging ...
(Date:10/11/2017)... 11, 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), ... in Las Piedras, Puerto Rico , ... Following a ... sustained minor structural damage, temporary loss of power and ... been completed, manufacturing operations have resumed, and the company ...
Breaking Medicine Technology: