Navigation Links
Live virus implicates camels in MERS outbreak
Date:4/28/2014

There is new, more definitive evidence implicating camels in the ongoing outbreak of Middle East Respiratory Syndrome, or MERS. Scientists at the Center for Infection and Immunity at Columbia University's Mailman School of Public Health, King Saud University, and EcoHealth Alliance extracted a complete, live, infectious sample of MERS coronavirus from two camels in Saudi Arabia. The sample matched MERS coronavirus (MERS-CoV) found in humans, indicating that the virus in camels is capable of infecting humans and that camels are a likely source of the outbreak.

Results appear online in the journal mBio.

The researchers examined nasal samples collected during a countrywide survey of dromedary camels and selected samples from two animals with the highest viral load. They cultured and obtained complete genomic sequence from both animals as well as virus in nasal samples from several other camels.

The mathematical means of all genetic sequences (the consensus genomic sequences) were consistent with viruses found in human cases; however, samples from camels contained more than one virus genotype. Over a period of 48 hours of culture in primate cells, the genomic variation of viruses narrowed, mirroring the lower sequence diversity reported in MERS-CoV found in humans.

"The finding of infectious virus strengthens the argument that dromedary camels are reservoirs for MERS-CoV," says first author Thomas Briese, PhD, associate director of the Center for Infection and Immunity and associate professor of Epidemiology at the Mailman School. "The narrow range of MERS viruses in humans and a very broad range in camels may explain in part the why human disease is uncommon: because only a few genotypes are capable of cross species transmission," adds Dr. Briese.

"Given these new data, we are now investigating potential routes for human infection through exposure to camel milk or meat products," says co-author Abdulaziz N. Alagaili, PhD, director of the Mammals Research Chair at King Saud University. "This report builds on work published earlier this year when our team found that three-quarters of camels in Saudi Arabia carry MERS virus."

To date, at least 300 people have been infected with the virus that causes MERS and approximately 100 have died since the first documented case in Saudi Arabia in September 2012. Of these, more than 60about one-fourth of the global total since MERS was identifiedhave been reported in the past month. Most cases have been in Saudi Arabia, with lower numbers in Jordan, Qatar, Tunisia, and the United Arab Emirates. France, Germany, Italy, and the United Kingdom, and more recently Malaysia and the Philippines, have also reported cases related to travel to the Middle East. While human-to-human transmission has occurred, the source of the disease in most cases has remained a mystery.

"Although there is no evidence that MERS-CoV is becoming more transmissible, the recent increase in reported cases is a cause for concern," says senior author W. Ian Lipkin, MD, director of the Center for Infection and Immunity and the John Snow Professor of Epidemiology at the Mailman School. "It is essential that investigators commit to data and sample sharing so that this potential threat to global health is addressed by the entire biomedical research community."


'/>"/>

Contact: Timothy S. Paul
tp2111@columbia.edu
212-305-2676
Columbia University's Mailman School of Public Health
Source:Eurekalert

Related medicine news :

1. NIH scientists establish monkey model of hantavirus disease
2. Novel therapeutic agent for Tamiflu-resistant pH1N1 influenza virus discovered
3. How the body fights against viruses
4. Animal study provides first evidence that gel can prevent multiple virus transmission in vagina/rectum
5. Prognosis of tumors positive for human papilloma virus in head and neck cancers varies according to the site
6. Scripps Florida scientist awarded $2.3 million to study dengue fever and related viruses
7. Saudi Arabian camels carry MERS virus
8. HIV drug used to reverse effects of virus that causes cervical cancer
9. Skin cell response to environmental stimuli like viruses may predict type 1 diabetes
10. Lab-grown, virus-free stem cells repair retinal tissue in mice
11. Research shows early promise of new drug for cancers caused by viruses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2017)... ... May 27, 2017 , ... In any business, follow up is critical to ... dental team at presenting treatment, there will always be some patients who can’t or ... money on best practices when it comes to presenting treatment. After the patient ...
(Date:5/26/2017)... ... 26, 2017 , ... Leading CEOs from biotech, pharmaceutical, and ... 31st at The Four Seasons Hotel Boston. , The Boston CEO Conference ... exclusive access to key decision makers who influence deal making and investment. Attendees ...
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... ... premium delicatessen foods, is sharing bold recipes for Memorial Day entertaining that are ... menus. , “Boar’s Head fresh sliced meats and cheeses featured in these ...
(Date:5/26/2017)... ... May 26, 2017 , ... Silver Birch of Hammond, a new assisted lifestyle ... than four acres of land at 5620 Sohl Avenue in Hammond, serves older adults ... includes 125 studio and one-bedroom apartments. Each of the private apartments at Silver Birch ...
(Date:5/26/2017)... ... May 26, 2017 , ... Centennial-based BluSky Restoration Contractors announced ... 14th Annual Clays for Kids fundraiser, to be held Friday, Sept. 22, at ... As part of BluSky’s partnership with The Adoption Exchange, BluSky will also share ...
Breaking Medicine News(10 mins):
(Date:5/26/2017)... , May 25, 2017  In response to ... , Direct Relief is working with Pfizer to ... available at no cost to community health centers, free ... providers nationwide. "Pfizer has a long-standing ... medicines and ensuring patient safety through educational activities," said ...
(Date:5/18/2017)... 2017  Two Bayer U.S. Pharmaceutical leaders received top ... recent 28 th Woman of the Year ... HBA,s longstanding mission of furthering the advancement and impact ... Cindy Powell-Steffen , senior director of brand activation ... Libby Howe , a regional business manager for ...
(Date:5/11/2017)... TORONTO , May 11, 2017  Thornhill ... ) has been awarded an $8,049,024 USD five-year, ... Defense through the Canadian Commercial Corporation (CCC) ( ... Field Anesthesia Systems to administer general anesthesia to ... environment.  "The US Marine Corps have ...
Breaking Medicine Technology: