Navigation Links
Live recordings of cell communication
Date:8/6/2009

Neurons communicate with each other with the help of nano-sized vesicles. Disruption of this communication process is responsible for many diseases and mental disorders like e.g. depression. Nerve signals travel from one neuron to another through vesicles - a nano-sized container loaded with neurotransmitter molecules. A vesicle fuses with the membrane surrounding a neuron, releases neurotransmitters into the surroundings that are detected by the next neuron in line. However, we still lack a more detailed understanding of how the fusion of vesicles occurs on the nano-scale.

Associate Professor Dimitrios Stamou, Department of Neuroscience and Pharmacology and Nano-Science Center explains:

- "Contact between vesicles and membranes are an essential step in many important biological processes. We can now quantify contact areas formed between vesicles and determine the vesicle size and shape with nano-scale resolution. This helps us characterise the properties of the molecules involved in vesicle-fusion. The new method opens great new prospects for the research of neurological and infectious diseases".

Images on the nano-scale

The researchers are using a method called FRET or Fluorescence Resonance Energy Transfer. The method is well known, but what is new is the way the researchers are using it. They produce vesicles in the laboratory, which contain fluorescent donor molecules, and membranes fixed to a surface. The fixed membranes contain acceptor fluorescent molecules. Only when the two different fluorescent molecules are near to each other will light be emitted, which researchers can measure as a sign of vesicle fusion. By measuring the emitted light the researchers found new ways to determine the vesicle shape with nano-scale resolution in real-time.

- "We have lacked a method for measuring the fusion of vesicle and membrane on a nano-scale at the moment the process occurs. Until now it has only been possible to get a still image of the process with high resolution, or live images with low resolution. With the new method we can quantify the changes in vesicle shape live i.e. during fusion, and with nanoscale resolution", explains Dimitrios Stamou.


'/>"/>

Contact: Dimitrios Stamou
stamou@nano.ku.dk
454-116-0468
University of Copenhagen
Source:Eurekalert

Related medicine news :

1. New York Transcription Company Finds Digital Audio Recordings Still Problematic
2. Wyclef Jean and Miri Ben-Ari to Lead Phoenix House Tribute to Lisa Ellis of Fireman Capital Partners and Carnival House Recordings
3. Omnicom Acquires Leading Healthcare Marketing Communications Firm in China
4. MedThink Communications Retained by NanoBio Corporation
5. National Patient Safety Foundation Partners with Vocera Communications
6. EDAP Launches Enhanced Communication Plans at SIU Paris Congress
7. Vida Health Communications, Inc. to Be Honored as Tibbetts Award Winner
8. Communication in cancer world is key to survival
9. Dr. Louis Sullivans Symphony of Health Care Delivery Stresses Importance of Communication, Quality Research in Health Care
10. N. V. Perricone M.D. Cosmeceuticals Elevates Role of Christina Banas to Executive Director Global Communications
11. Publicis Groupe Strengthens its Leadership in Digital and Integrated Healthcare Communications in Italy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize each ... Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into hand ... select a ProHand generator and drag it above media or text in the Final ...
(Date:6/25/2016)... ... ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors in ... School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green Hospital ... at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train in ...
(Date:6/25/2016)... , ... June 25, 2016 , ... On Friday, June ... a Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments ... of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott ...
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
(Date:6/24/2016)... , ... June 24, 2016 , ... June 19, 2016 ... dangers associated with chronic pain and the benefits of holistic treatments, Serenity Recovery ... are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
(Date:6/24/2016)... 24, 2016  Arkis BioSciences, a leading innovator ... more durable cerebrospinal fluid treatments, today announced it ... funding is led by Innova Memphis, followed by ... private investors.  Arkis, new financing will accelerate the ... market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... HILLS, Calif. , June 23, 2016 Any ... the many challenges of the current process. Many of them ... because of the technical difficulties and high laboratory costs involved. ... have to offer it at such a high cost that ... afford it. Dr. Parsa Zadeh , founder ...
Breaking Medicine Technology: