Navigation Links
Live recordings of cell communication
Date:8/6/2009

Neurons communicate with each other with the help of nano-sized vesicles. Disruption of this communication process is responsible for many diseases and mental disorders like e.g. depression. Nerve signals travel from one neuron to another through vesicles - a nano-sized container loaded with neurotransmitter molecules. A vesicle fuses with the membrane surrounding a neuron, releases neurotransmitters into the surroundings that are detected by the next neuron in line. However, we still lack a more detailed understanding of how the fusion of vesicles occurs on the nano-scale.

Associate Professor Dimitrios Stamou, Department of Neuroscience and Pharmacology and Nano-Science Center explains:

- "Contact between vesicles and membranes are an essential step in many important biological processes. We can now quantify contact areas formed between vesicles and determine the vesicle size and shape with nano-scale resolution. This helps us characterise the properties of the molecules involved in vesicle-fusion. The new method opens great new prospects for the research of neurological and infectious diseases".

Images on the nano-scale

The researchers are using a method called FRET or Fluorescence Resonance Energy Transfer. The method is well known, but what is new is the way the researchers are using it. They produce vesicles in the laboratory, which contain fluorescent donor molecules, and membranes fixed to a surface. The fixed membranes contain acceptor fluorescent molecules. Only when the two different fluorescent molecules are near to each other will light be emitted, which researchers can measure as a sign of vesicle fusion. By measuring the emitted light the researchers found new ways to determine the vesicle shape with nano-scale resolution in real-time.

- "We have lacked a method for measuring the fusion of vesicle and membrane on a nano-scale at the moment the process occurs. Until now it has only been possible to get a still image of the process with high resolution, or live images with low resolution. With the new method we can quantify the changes in vesicle shape live i.e. during fusion, and with nanoscale resolution", explains Dimitrios Stamou.


'/>"/>

Contact: Dimitrios Stamou
stamou@nano.ku.dk
454-116-0468
University of Copenhagen
Source:Eurekalert

Related medicine news :

1. New York Transcription Company Finds Digital Audio Recordings Still Problematic
2. Wyclef Jean and Miri Ben-Ari to Lead Phoenix House Tribute to Lisa Ellis of Fireman Capital Partners and Carnival House Recordings
3. Omnicom Acquires Leading Healthcare Marketing Communications Firm in China
4. MedThink Communications Retained by NanoBio Corporation
5. National Patient Safety Foundation Partners with Vocera Communications
6. EDAP Launches Enhanced Communication Plans at SIU Paris Congress
7. Vida Health Communications, Inc. to Be Honored as Tibbetts Award Winner
8. Communication in cancer world is key to survival
9. Dr. Louis Sullivans Symphony of Health Care Delivery Stresses Importance of Communication, Quality Research in Health Care
10. N. V. Perricone M.D. Cosmeceuticals Elevates Role of Christina Banas to Executive Director Global Communications
11. Publicis Groupe Strengthens its Leadership in Digital and Integrated Healthcare Communications in Italy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... ... a crisis. Her son James, eight, was out of control. Prone to extreme mood shifts ... upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife ... and say he was going to kill them. If we were driving on the ...
(Date:6/24/2016)... ... 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 ... by their peers for this recognition are considered among the top 2 percent of ... honors as members of this year’s Legal Elite Hall of Fame: Miami Shareholders ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Comfort Keepers® ... American Cancer Society and the Road To Recovery® program to drive cancer patients to ... and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... ... 2016 , ... People across the U.S. are sharpening their pencils and honing ... contest in which patients and their families pay tribute to a genetic counselor by ... Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In ...
(Date:6/24/2016)... ... 24, 2016 , ... The Haute Beauty Network, affiliated with ... as a prominent plastic surgeon and the network’s newest partner. , Dr. ... handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands by ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... FRANCISCO, Calif. , June 24, 2016 /PRNewswire/ ... ), a biopharmaceutical company developing novel therapeutics for ... unmet needs, today announced the closing of its ... of common stock, at the public offering price ... in the offering were offered by GBT. GBT ...
(Date:6/24/2016)... , June 24, 2016 The Academy of ... recommendations that would allow biopharmaceutical companies to ... entities that make formulary and coverage decisions, a move ... of new medicines. The recommendations address restrictions ... appear on the drug label, a prohibition that hinders ...
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
Breaking Medicine Technology: