Navigation Links
Lithium of No Benefit in ALS, Study Finds
Date:8/11/2010

By Kathleen Doheny
HealthDay Reporter

WEDNESDAY, Aug. 11 (HealthDay News) -- A new study appears to dash hopes that the psychiatric drug lithium can benefit patients with amyotrophic lateral sclerosis (ALS).

The investigation involving 171 people with ALS was stopped early, in November 2009, because of high dropout rates from death, side effects or because patients thought the drug was ineffective.

ALS -- sometimes called Lou Gehrig's disease after the N.Y. Yankee who died of the condition -- is a progressive nervous system disorder that causes weakness in muscles, including those controlling breathing and swallowing. Median survival is three years, and only one drug -- riluzole -- is approved for ALS treatment in the United States.

Interest in lithium, which is often used to treat bipolar disorder, increased after a small Italian study was published two years ago, suggesting a beneficial effect for ALS patients, said Dr. Adriano Chio, an associate professor of neurology at the University of Torino, Italy. In that study, lithium was thought to have prolonged survival of 16 ALS patients, Chio said.

How might lithium have helped?

"Lithium could have an effect on one of the mechanisms supposedly related to the motor neuron degeneration in ALS, the accumulation of pathological proteins in the neuron," said Chio, who led the new study, noting subsequent research has not confirmed this effect.

In the new study, published in the Aug. 17 issue of Neurology, the drop-out rate, at 68 percent, was two times higher than the drop-out rate reported by previous trials, Chio said.

All participants received lithium, but in two different doses, and the drug was not well-tolerated by either group. Patients died or lost their autonomy at the same rate in both groups.

In an editorial accompanying the study, Dr. Carmel Armon of Tufts University said one limitation of the Chio study, which Chio a
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. No Evidence That Lithium Helps in ALS
2. 30 million women to benefit from health reform law
3. Researchers study benefits of white button mushrooms
4. Study finds patients benefit from thorough discussion of recommended operations
5. Society of Interventional Radiology advances global definition of specialty, benefits patients
6. Social Security Disability Benefits Can Be Crucial to Surviving With Spinal Cord Injury, Allsup Reports
7. Advocate Health Care Reports $462 Million in Community Benefits
8. Parkinson's Disease Patient Tells Personal Story to Benefit PD Research; Donates Book Proceeds to PD Charities
9. Mulago Positive Women's Network Announce Their "BONO" Bracelet Fundraiser to Benefit HIV+ Women in Uganda
10. Intensively lowering glucose: Possible benefits must be weighed against risks
11. Examining risks and benefits of alcohol consumption
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Lithium of No Benefit in ALS, Study Finds
(Date:6/30/2015)... Diego, California (PRWEB) , ... June 30, 2015 , ... ... Solar Power today at a media event in San Diego. Speakers and clean air ... Diego School of medicine, Natalie Germuska of Kindred Hospital, and Daniel Sullivan, founder and ...
(Date:6/30/2015)... CA (PRWEB) , ... June 30, 2015 , ... According ... has received a $3.1 million grant to study how sensory stimuli can be used ... special emphasis on improving care for children with autism, will compare patient experience in ...
(Date:6/30/2015)... ... June 30, 2015 , ... After many requests from ... its here, http://www.express-glasses.com is proud to announce its collaboration with DHL ... shipping with DHL Express when calling or visiting the express glasses website. express ...
(Date:6/30/2015)... ... June 30, 2015 , ... Rocky Mountain Oils, a leading non-MLM ... team and added a new CEO, Mr. Darold Francis. The changes will help enhance ... essential oils that customers have come to know and respect for over eight years. ...
(Date:6/30/2015)... Parsippany, NJ (PRWEB) , ... June 30, 2015 ... ... as executive vice president and general manager of HRA Healthcare Research & ... Plainsboro, N.J.-based Michael J. Hennessy Associates, Inc. (MJH) family of businesses. HRA offers ...
Breaking Medicine News(10 mins):Health News:Local Dignitaries Gather to Announce San Diego’s Clean Air Challenge 2Health News:Local Dignitaries Gather to Announce San Diego’s Clean Air Challenge 3Health News:New Study Aims to Determine if Sensory Stimuli can Ease Dental Anxiety in Children, Notes Medical Center Dental Care 2Health News:New Study Aims to Determine if Sensory Stimuli can Ease Dental Anxiety in Children, Notes Medical Center Dental Care 3Health News:Eyeglasses Online - Express Glasses Announcing New International Shipping Using DHL 2Health News:Rocky Mountain Oils Adds New CEO, Announces Relocation of Operations to Orem, Utah 2Health News:HRA Healthcare Research & Analytics Welcomes 'Creative Problem Solver' as New Executive Vice President 2Health News:HRA Healthcare Research & Analytics Welcomes 'Creative Problem Solver' as New Executive Vice President 3
... Seek Vote to Join More Than 55,000 Others Who Have ... Calif., Jan. 8 /PRNewswire-USNewswire/ -- Healthcare ... elections to join more than 55,000 other union members who ... International Union - United Healthcare Workers West (SEIU-UHW), rather than ...
... Quercetin , FRIDAY, Jan. 8 (HealthDay News) -- Researchers ... in hepatitis C infection, and they say the finding may ... which can lead to cirrhosis and liver cancer. , The ... can cause major side effects and aren,t effective in all ...
... of uridine, choline and DHA boosted memory of Alzheimer,s patients ... A combination of three nutrients might help improve memory in ... (synapses), a new study shows. , Uridine, choline and the ... precursors to the fatty molecules that make up brain cell ...
... , , - Subtle ... , PHILADELPHIA, Jan 8 Children with autism spectrum disorders (ASDs) ... children without ASDs, and measuring magnetic signals that mark this delay ... http://www.newscom.com/cgi-bin/prnh/20100108/DC34671 ) , Researchers at The Children,s Hospital ...
... Jan. 8 Gilbert Hospital expects patient volume at its ... and continued easing of the nationwide economic unrest have officials ... this community-based hospital. , "We are expecting smaller growth and ... east valley, but the state and the nation," said Randy ...
... , GILBERT, Ariz., Jan. 8 Gilbert Hospital continued ... patient visits through the emergency department, patient levels remained constant ... Doc in 31 Minutes" continued its success with more than ... certified physician within 31 minutes of arrival. Additionally, the average ...
Cached Medicine News:Health News:SEIU-UHW Members at 26 Hospitals and Nursing Homes Seeking Elections Against Group Started by the Union's Ousted Leaders 2Health News:SEIU-UHW Members at 26 Hospitals and Nursing Homes Seeking Elections Against Group Started by the Union's Ousted Leaders 3Health News:Key to Hepatitis C May Be Two Cellular Proteins 2Health News:Brain Imaging May Help Diagnose Autism 2Health News:Brain Imaging May Help Diagnose Autism 3Health News:Brain Imaging May Help Diagnose Autism 4Health News:Gilbert Hospital Forecasts Steady 2010 2Health News:Gilbert Hospital 2009 Emergency Department Year in Review 2
(Date:6/30/2015)... ALISO VIEJO, Calif. , June 30, 2015 ... from the PRISM II study showing that treatment ... statistically significant reduction in symptoms of pseudobulbar affect ... or stroke. PBA is a distressing condition characterized ... crying resulting from certain neurologic diseases or brain ...
(Date:6/30/2015)... – Small Cap IR issues report. Recently, Arrayit Corporation ... blood card technology to Vivos, Global Genome Vault, the ... an impervious, impenetrable and permanent DNA storage vault, able ... Earth, a safe and secure nuclear blast-proof, underground shelter ... rapid collection, separation, drying and storage of human genomic ...
(Date:6/30/2015)... 2015  Egalet Corporation (Nasdaq: EGLT ... company focused on developing, manufacturing and marketing ... from a Category 3 human abuse liability ... oral oxycodone product candidate in late-stage clinical ... enough to require daily, around-the-clock opioid treatment ...
Breaking Medicine Technology:Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 2Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 3Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 4Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 5Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 6Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 7Small Cap IR - Empowering the Age of Genetic Enlightenment 2Egalet Announces Top-Line Results from Oral Human Abuse Liability Study of Egalet-002 2Egalet Announces Top-Line Results from Oral Human Abuse Liability Study of Egalet-002 3Egalet Announces Top-Line Results from Oral Human Abuse Liability Study of Egalet-002 4Egalet Announces Top-Line Results from Oral Human Abuse Liability Study of Egalet-002 5
... Technologies, Inc. (NYSE Amex: PTN ), ... for the treatment of diseases with significant unmet ... Dr. Carl Spana, President and Chief Executive Officer ... Eighth Annual Equity Conference.  The presentation is scheduled ...
... YORK, Jan. 16, 2012 Reportlinker.com announces ... available in its catalogue: , ... http://www.reportlinker.com/p0760637/Pharmaceutical-MA-in-the-Asia-Pacific-Region.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Pharmaceutical ... continues in major developed markets, prompted by ...
Cached Medicine Technology:Palatin Technologies to Present at BOCEMb, Noble Financial Capital Markets' Eighth Annual Equity Conference 2Pharmaceutical M&A in the Asia Pacific Region 2Pharmaceutical M&A in the Asia Pacific Region 3Pharmaceutical M&A in the Asia Pacific Region 4
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: