Navigation Links
Lithium chloride slows onset of skeletal muscle disorder
Date:3/18/2008

Irvine, Calif., March 18, 2008 -- A new UC Irvine study finds that lithium chloride, a drug used to treat bipolar disorder, can slow the development of inclusion body myositis, a skeletal muscle disease that affects the elderly.

In the study by scientists Frank LaFerla and Masashi Kitazawa, mice genetically engineered to have IBM demonstrated markedly better motor function six months after receiving daily doses of lithium chloride, compared with non-treated mice. The muscles in treated mice also had lower levels of a protein that the study linked to muscle inflammation associated with IBM.

These data are the first to show that lithium chloride is a potential IBM therapy.

"Lithium chloride is an approved drug for treating humans. We already know it is safe and can be used by people," said LaFerla, professor of neurobiology and behavior at UCI and co-author of the study. "Given our findings, we believe a clinical trial that tests the effectiveness of lithium chloride on IBM patients should be conducted as soon as possible."

Results of the study appear online this month in the journal Annals of Neurology.

IBM is the most common skeletal muscle disorder among people older than 50. People with IBM experience weakness, inflammation and atrophy of muscles in their fingers, wrists, forearms and quadriceps. There is no cure for IBM, nor is there an effective treatment, according to the National Institutes of Health.

LaFerla, a noted Alzheimer's disease researcher, began studying IBM about 10 years ago after learning the disorders have similar tissue characteristics. In the brain, a buildup of phosphorylated tau protein leads to the development of tangles, one of the two lesions that are hallmarks of Alzheimer's disease. High phospho-tau levels also are present in IBM, though patients do not experience dementia or memory loss. In a previous study,

LaFerla found that lithium chloride reduced phospho-tau l
'/>"/>

Contact: Jennifer Fitzenberger
jfitzen@uci.edu
949-824-3969
University of California - Irvine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Possible genetic predictor for response to lithium augmentation in depressed patients
2. Perrigo Company to Market Over-the-Counter Cetirizine Hydrochloride, Pseudoephedrine Hydrochloride Extended-Release Tablets
3. OSHA Extends Comment Period for Lookback Review of Methylene Chloride Standard
4. Roxane Laboratories, Inc. Announces the Launch of Granisetron Hydrochloride Tablets, 1mg
5. Ranbaxy Receives Final Approval to Manufacture and Market Cetirizine Hydrochloride Tablets (OTC), 5mg and 10mg
6. Mylan Announces Final FDA Approval for Cetirizine Hydrochloride Tablets
7. Amneal Receives FDA Approval for Bethanechol Chloride Tablets, USP Using New Expedited FDA Approval Process
8. Mylan Announces Settlement of Paroxetine Hydrochloride Extended-Release Tablets with GlaxoSmithKline
9. Use of Methamphetamine Among U.S. Workers and Job Applicants Drops 22 Percent in 2007 and Cocaine Use Slows Dramatically, Reports Quest Diagnostics
10. High zinc status in lung cells slows growth and induces DNA damage-induced gene expression
11. Viral Therapy Slows Pediatric Tumors in Mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... ... 01, 2015 , ... Ormco Corporation, a leading manufacturer and ... Smile for a Lifetime Foundation (S4L) fundraising event held at the 14th Annual ... S4L in its mission to provide free quality orthodontic care to individuals with ...
(Date:7/1/2015)... NY (PRWEB) , ... July 01, 2015 , ... The ... from the New York Community Trust. The grant will allow CCF to improve quality ... proven practices. , CCF was formed to respond to many changes in New York’s ...
(Date:7/1/2015)... ... July 01, 2015 , ... During ... Posey (Manager, National Sales Training and Development) and Chuck Corso (Associate Sales Trainer) ... in Phoenix, AZ. LTEN brings together learning and development professionals from more than ...
(Date:7/1/2015)... ... July 01, 2015 , ... As if mood swings, ... in a significant number of women: leg pain. Northeast Houston Vein Center is offering ... a symptom of venous reflux disease, is underdiagnosed and often overlooked. Many women experience ...
(Date:7/1/2015)... ... July 01, 2015 , ... RowdMap Inc. is a ... white paper: “Pro-actively Identifying the High-Cost Patient Population: Insights from the Health Care ... at: http://www.hcttf.org/resouces-tools . , The Healthcare Transformation Task Force is a group ...
Breaking Medicine News(10 mins):Health News:The Forum Fundraiser Raises $80,000 for the Smile for a Lifetime Foundation 2Health News:The Forum Fundraiser Raises $80,000 for the Smile for a Lifetime Foundation 3Health News:The Collaborative for Children and Families Receives a Grant From The New York Community Trust to Build Capacity for Comprehensive Child Welfare 2Health News:The Collaborative for Children and Families Receives a Grant From The New York Community Trust to Build Capacity for Comprehensive Child Welfare 3Health News:Mission Pharmacal Company: Alamo Pharma Services' Training Leaders Take Steps to Further Expand Capabilities for Mission Pharmacal and Other Clients 2Health News:Mission Pharmacal Company: Alamo Pharma Services' Training Leaders Take Steps to Further Expand Capabilities for Mission Pharmacal and Other Clients 3Health News:Mission Pharmacal Company: Alamo Pharma Services' Training Leaders Take Steps to Further Expand Capabilities for Mission Pharmacal and Other Clients 4Health News:Northeast Houston Vein Center Offers Tips for Women with Leg Pain 2Health News:Northeast Houston Vein Center Offers Tips for Women with Leg Pain 3Health News:A Population Based Approach to Pay for Value: RowdMap, Inc. Contributes to Health Care Transformation Task Force White Paper 2Health News:A Population Based Approach to Pay for Value: RowdMap, Inc. Contributes to Health Care Transformation Task Force White Paper 3
... of India-Marxist (CPI-M) and yoga guru Ramdev clashed violently on ... // reported to have raised slogans against the CPI-M ... the guru were laced with animal and human body parts. ... tried to forcibly enter the office of the party. ...
... Confusion still prevails over the death of the child in Turkey. ... places in South East Asia about the spread of the disease. ... five children in the family (Turkey). Initially the boy died after ... not confirmed the death of the boy, probably due to H5N1 ...
... pilot study by The New Women's Health Initiative (WHI) ... but rich in carbohydrates results in negligible weight gain. ... weight alterations in postmenopausal women Vis a Vis variations ... this category were advised to reduce the fat consumption ...
... help in slowing down the progress of Alzheimer's disease, ... and Chile. The healthy brain // ... their study, to be published in the American Chemical ... surgery, has the potential to destroy beta-amyloid fibrils and ...
... leaflet claiming that traditional Chinese medicine was safer than ... in the UK, an industry watchdog said on Wednesday. ... treatment from qualified doctors for serious medical conditions, the ... by Ever Well Ltd, also claimed that serious medical ...
... Ministry is planning for reduction of waiting time spent by ... to reduce the non-emergency surgery time to less // ... Government is hoping the project will be made completed by ... appointment with the doctor, for getting diagnostic and scan tests ...
Cached Medicine News:Health News:Chinese medicine leaflet broke advertising code 2
(Date:7/1/2015)...   Continental Clinical Solutions (Continental) announced it is expanding its Baltimore ... volume in clinical studies and demand for unique patient populations.  ... ... ... ...
(Date:7/1/2015)... , July 1, 2015 OncoSec Medical Inc. ... cancer immunotherapies, today announced that CEO and President Punit ... of the Company,s listing to The Nasdaq Stock Market at ... MarketSite in New York City .   ... investors, and stakeholders, we are honored to open the Nasdaq ...
(Date:7/1/2015)... 2015 The global mHealth ... USD 49,119.2 million by 2020, according to a new ... expected to remain the dominant and fastest growing market ... 2012, and an estimated CAGR of 49.7% from 2014 ... , Browse full research report with TOC ...
Breaking Medicine Technology:Continental Clinical Solutions CEO Saleh Stevens Eyes Growth 2Continental Clinical Solutions CEO Saleh Stevens Eyes Growth 3Continental Clinical Solutions CEO Saleh Stevens Eyes Growth 4OncoSec Medical to Ring The Nasdaq Stock Market Opening Bell 2OncoSec Medical to Ring The Nasdaq Stock Market Opening Bell 3mHealth Market Worth $ 49,119.2 Million By 2020: Grand View Research, Inc. 2mHealth Market Worth $ 49,119.2 Million By 2020: Grand View Research, Inc. 3mHealth Market Worth $ 49,119.2 Million By 2020: Grand View Research, Inc. 4mHealth Market Worth $ 49,119.2 Million By 2020: Grand View Research, Inc. 5
... Reportlinker.com announces that a new market ... Fetal Monitoring, Diagnostics and ... An overview of the ... tests. Analysis of market trends, with data ...
... -- Nutrastar International Inc. (OTCBB: NUIN; "Nutrastar" or the ... Traditional Chinese Medicine ("TCM") consumer products, today announced that ... conference call on Monday, May 16, 2011 at 8:00 ... the public pre-market on Monday, May 16, 2011. ...
Cached Medicine Technology:Reportlinker Adds Fetal Monitoring, Diagnostics and Predictive Tests 2Reportlinker Adds Fetal Monitoring, Diagnostics and Predictive Tests 3Reportlinker Adds Fetal Monitoring, Diagnostics and Predictive Tests 4Reportlinker Adds Fetal Monitoring, Diagnostics and Predictive Tests 5Reportlinker Adds Fetal Monitoring, Diagnostics and Predictive Tests 6Reportlinker Adds Fetal Monitoring, Diagnostics and Predictive Tests 7Reportlinker Adds Fetal Monitoring, Diagnostics and Predictive Tests 8Reportlinker Adds Fetal Monitoring, Diagnostics and Predictive Tests 9Reportlinker Adds Fetal Monitoring, Diagnostics and Predictive Tests 10Reportlinker Adds Fetal Monitoring, Diagnostics and Predictive Tests 11Nutrastar Provides First Quarter 2011 Financial Results Release Date and Conference Call Details 2Nutrastar Provides First Quarter 2011 Financial Results Release Date and Conference Call Details 3
... The ABL800 FLEX is a fully ... most advanced blood gas analyzer along ... gives you the freedom to focus ... FLEX provides features that are essential ...
Flatbed Agitator....
Flatbed Agitator....
... platelet agitators offer a wide range of ... the drawer storage platform to agitate smoothly, ... wear down and squeak. Sturdy, one-piece perforated ... air circulation for your platelets., ,i.Series platelet ...
Medicine Products: