Navigation Links
Lipids help to fight leukemia
Date:6/16/2014

T cells use a novel mechanism to fight leukemia. They may recognize unique lipids produced by cancer cells and kill tumor cells expressing these lipid molecules. A study conducted by researchers at the University of Basel shows that a tumor-associated lipid stimulates specific T cells, which efficiently kill leukemia cells both in vitro and in animal models. The results have been published in the Journal of Experimental Medicine.

Leukemias are cancer diseases affecting blood cells . Acute leukemias prevent development of normal bold cells and thereby are severe life-threatening diseases. Current therapy for acute leukemias is based on chemotherapy that eradicates tumor cells followed by bone-marrow stem cell transplantation that reconstitutes the patient with healthy blood cells. In some cases, leukemia cells survive this treatment and start to re-grow. A major aim of many studies is finding novel and efficient ways to detect and eradicate leukemia cells before a second outbreak of the disease.

More punch against tumor cells

T lymphocytes are major contributors to fight against leukemias. T cells may recognize and become activated by tumor-specific protein antigens in some instances produced in large amounts only by tumor cells. These protein antigens are also called tumor-associated antigens (TAA) and stimulate specific T cells, which in turn kill leukemia cells. However, protein TAA accumulation can be drastically reduced by variant leukemia cells and some TAA may change their structure, thus preventing recognition by T cells and facilitating tumor immune evasion.

Prof. Gennaro De Libero and his team from the Department of Biomedicine at the University of Basel has identified a new approach that might help to make the immune system more efficient in recognizing leukemia cells. His research team is studying T cells that specifically recognize lipid antigens since several years. Together with colleagues in Italy, China and Singapore, the Swiss team has identified a new lipid that accumulates in leukemia cells and that stimulates specific T cell responses. The new lipid methyl-lysophosphatidic acid (mLPA) is very abundant in several forms of human leukemias and is the first example of a lipid TAA.

Therapeutic implications in human leukemia

The published study also shows that it is possible to isolate human T cells that specifically recognize and kill mLPA-expressing leukemia cells in in vitro tests. When these T cells were transplanted into mice, they also displayed great in vivo therapeutic efficacy against leukemia cells.

An important feature of mLPA is that differently from protein TAA, it does not change its structure, and remains abundant in leukemia cells. The Swiss team is now investigating, whether mLPA can be used to target leukemia cells in addition to protein TAA. This type of immunotherapy may be extremely beneficial in preventing relapses of the disease after chemotherapy and bone marrow transplantation. It opens new avenues to novel non-invasive cancer immunotherapies.


'/>"/>
Contact: Olivia Poisson
olivia.poisson@unibas.ch
University of Basel
Source:Eurekalert  

Related medicine news :

1. Asha Nutrition Sciences Launches Pre-sales Fundraising Campaign to Promote Tailored Lipids, LipiLife
2. Tomato therapy: Engineered veggies target intestinal lipids, improve cholesterol
3. In the spotlight: The fight over preservatives in personal care products
4. Compact proton therapy for fight against cancer
5. Text messaging program helps smokers fight the urge to light up
6. Testing the waters to fight infections like fish
7. Not just for the heart, red wine shows promise as cavity fighter
8. Study shows how streptococcal bacteria can be used to fight colon cancer
9. Detailed studies reveal how key cancer-fighting protein is held in check
10. Researchers propose treating prison population to fight US hepatitis C epidemic
11. Standard assessments miss early signs of cardiovascular disease in firefighters
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Lipids help to fight leukemia
(Date:5/28/2016)... ... 28, 2016 , ... After a year and a half of planning the Multiple Pathways ... The Multiple Pathways of Recovery Conference was held May 2 -4, 2016 at the ... Kingdom came together to explore the many pathways individuals use to get into and sustain ...
(Date:5/27/2016)... ... May 27, 2016 , ... Southland Log Homes , designer and manufacturer ... barn kits, which can be found on its website at SouthlandLogHomes.com. , The designs ... and they highlight the craftsmanship of timber post and beam construction. The result ...
(Date:5/27/2016)... York, NY (PRWEB) , ... May 27, 2016 , ... ... campaign returns for a third time to shed lights on the variety of topics ... and inspirational stories, “Nurse Appreciation” tackles why this career has gone from being in ...
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... ... readers, this installment is bolstered by inspiring human-interest stories, courtesy of awareness-driven celebrities ... within the industry, from leading advocates, associations and industry leaders such as Bioness. ...
(Date:5/27/2016)... NY (PRWEB) , ... May 27, 2016 , ... ... world, this installment is bolstered by inspiring human interest stories, courtesy of leaders ... developing trends and tech within the industry, from leading advocates and associations—namely Jones ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... 25, 2016 According to a ... (3D, 2D, 4D), by Therapeutic Area (Oncology, Cosmeceutical/Plastic Surgery), ... (Medical Device Manufacturers, Hospitals/ Clinics) - Forecast to 2021", ... Animation Market for the forecast period of 2016 to ... Million by 2021 from USD 117.3 Million in 2016, ...
(Date:5/25/2016)...  Zymo Research Corp. announced today the final ... that help researchers obtain the most accurate and ... rapid growth of the study of microbiomes has ... methods to improve the reproducibility and quality of ... every step of the measurement process including collection ...
(Date:5/25/2016)... 25, 2016 As illustrated by ... this month, the numbers and momentum of cannabis in ... into the billions, more research and development push the ... State of Legal Marijuana Markets Report  from from ArcView ... much of the increase in sector is attributed to ...
Breaking Medicine Technology: