Navigation Links
Lipid levels during prenatal brain development impact autism: York U study
Date:4/8/2014

In a groundbreaking York University study, researchers have found that abnormal levels of lipid molecules in the brain can affect the interaction between two key neural pathways in early prenatal brain development, which can trigger autism. And, environmental causes such as exposure to chemicals in some cosmetics and common over-the-counter medication can affect the levels of these lipids, according to the researchers.

"We have found that the abnormal level of a lipid molecule called Prostaglandin E2 in the brain can affect the function of Wnt proteins. It is important because this can change the course of early embryonic development," explains Professor Dorota Crawford in the Faculty of Health and a member of the York Autism Alliance Research Group.

This is the first time research shows evidence for cross-talk between PGE2 and Wnt signalling in neuronal stem cells, according to the peer reviewed study published at Cell Communication and Signaling.

Lead researcher and York U doctoral student Christine Wong adds, "Using real-time imaging microscopy, we determined that higher levels of PGE2 can change Wnt-dependent behaviour of neural stem cells by increasing cell migration or proliferation. As a result, this could affect how the brain is organized and wired. Moreover, we found that an elevated level of PGE2 can increase expression of Wnt-regulated genes Ctnnb1, Ptgs2, Ccnd1, and Mmp9. "Interestingly, all these genes have been previously implicated in various autism studies."

Autism is considered to be the primary disorder of brain development with symptoms ranging from mild to severe and including repetitive behaviour, deficits in social interaction, and impaired language. It is four times more prevalent in boys than in girls and the incidence continues to rise. The US Center for Disease Control and Prevention (CDC) data from 2010 estimates that 1 in 68 children now has autism.

"The statistics are alarming. It's 30 per cent higher than the previous estimate of 1 in 88 children, up from only two years earlier. Perhaps we can no longer attribute this rise in autism incidence to better diagnostic tools or awareness of autism," notes Crawford. "It's even more apparent from the recent literature that the environment might have a greater impact on vulnerable genes, particularly in pregnancy. Our study provides some molecular evidence that the environment likely disrupts certain events occurring in early brain development and contributes to autism."

According to Crawford, genes don't undergo significant changes in evolution, so even though genetic factors are the main cause, environmental factors such as insufficient dietary supplementations of fatty acids, exposures to infections, various chemicals or drugs can change gene expression and contribute to autism.


'/>"/>

Contact: Gloria Suhasini
suhasini@yorku.ca
416-736-2100 x22094
York University
Source:Eurekalert

Related medicine news :

1. Asha Nutrition Sciences Launches Pre-sales Fundraising Campaign to Promote Tailored Lipids, LipiLife
2. Tomato therapy: Engineered veggies target intestinal lipids, improve cholesterol
3. Study finds few patients with newly-diagnosed hyperlipidemia receive recommended thyroid screening
4. POC Abused Drugs & Lipid Testing Market Analysis For US, Germany & Spain in New Research Reports at RnRMarketResearch.com
5. Faculty List for Continuing Medical Education (CME) Conference 17th Annual Conference on Hypertension, Diabetes and Dyslipidemia Released by Continuing Education Company
6. Researchers show that lipid nanoparticles are ideal for delivering genes and drugs
7. Statins have potential to treat an autoimmune clotting disorder called antiphospholipid syndrome
8. New medication shows promise as lipid-lowering therapy for rare cholesterol disorder
9. New lipid screening guidelines for children overly aggressive, UCSF researchers say
10. Lipid helps cells find their way by keeping their antennae up
11. Spinal cord injury researchers win Apple Award for article on niacin for dyslipidemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... New York, NY (PRWEB) , ... May 02, 2016 , ... ... Highlighting the year’s best in pet gear and toys, leading product review site ... TTPM Pets Paw of Excellence Awards at their Spring Showcase at the Metropolitan ...
(Date:5/2/2016)... NV (PRWEB) , ... May 02, 2016 , ... ... Pharmacy Times, has announced a new Specialty Pharmacy Patient Satisfaction Award that will ... based on the quarterly results from Zitter Health Insights’ Specialty Pharmacy Patient Satisfaction ...
(Date:5/2/2016)... ... 2016 , ... According to an American Psychological Association article, the ... before the age of 18. Of those who survive, many still face effects as ... , In her new book, Lyah! Lyah! Pants on Fyah!, she shares stories from ...
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... ... Research & Analytics EVP and GM Jim Callandrillo and Duane Reed, VP ... 55th Annual Pharmaceutical Business Intelligence and Research Group (PBIRG) General Meeting ...
(Date:5/2/2016)... ... May 02, 2016 , ... The Evolve Paddle Board ... affordable prices announced today the outcome of their partnership with Yoloha Yoga- producers of ... “Roots Yoga Board.” , SUP yoga has seen a dramatic rise in popularity throughout ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... , April 29, 2016 /PRNewswire/ ... Contamine, Directeur Financier Sanofi, ... santé, publie ses résultats pour le ... du Groupe, Jérôme Contamine, commente les ... et les perspectives pour le reste ...
(Date:4/29/2016)... April 29, 2016 Automation is ... laboratory due to the growing demands for productivity in ... contemporary automated systems are already adept of a wide ... tedious and manual labor. Instrumentation continues to evolve, and ... conceivable just a few years ago. Originally used mostly ...
(Date:4/28/2016)... , April 28, 2016  While Abbott,s announced ... the company,s valve repair and stent business, healthcare ... places Abbott more firmly into patient monitoring.  Kalorama ... fastest growing device areas, with double-digit growth expected ... report,  Advanced Remote Patient Monitoring . ...
Breaking Medicine Technology: