Navigation Links
Lipid levels during prenatal brain development impact autism: York U study
Date:4/8/2014

In a groundbreaking York University study, researchers have found that abnormal levels of lipid molecules in the brain can affect the interaction between two key neural pathways in early prenatal brain development, which can trigger autism. And, environmental causes such as exposure to chemicals in some cosmetics and common over-the-counter medication can affect the levels of these lipids, according to the researchers.

"We have found that the abnormal level of a lipid molecule called Prostaglandin E2 in the brain can affect the function of Wnt proteins. It is important because this can change the course of early embryonic development," explains Professor Dorota Crawford in the Faculty of Health and a member of the York Autism Alliance Research Group.

This is the first time research shows evidence for cross-talk between PGE2 and Wnt signalling in neuronal stem cells, according to the peer reviewed study published at Cell Communication and Signaling.

Lead researcher and York U doctoral student Christine Wong adds, "Using real-time imaging microscopy, we determined that higher levels of PGE2 can change Wnt-dependent behaviour of neural stem cells by increasing cell migration or proliferation. As a result, this could affect how the brain is organized and wired. Moreover, we found that an elevated level of PGE2 can increase expression of Wnt-regulated genes Ctnnb1, Ptgs2, Ccnd1, and Mmp9. "Interestingly, all these genes have been previously implicated in various autism studies."

Autism is considered to be the primary disorder of brain development with symptoms ranging from mild to severe and including repetitive behaviour, deficits in social interaction, and impaired language. It is four times more prevalent in boys than in girls and the incidence continues to rise. The US Center for Disease Control and Prevention (CDC) data from 2010 estimates that 1 in 68 children now has autism.

"The statistics are alarming. It's 30 per cent higher than the previous estimate of 1 in 88 children, up from only two years earlier. Perhaps we can no longer attribute this rise in autism incidence to better diagnostic tools or awareness of autism," notes Crawford. "It's even more apparent from the recent literature that the environment might have a greater impact on vulnerable genes, particularly in pregnancy. Our study provides some molecular evidence that the environment likely disrupts certain events occurring in early brain development and contributes to autism."

According to Crawford, genes don't undergo significant changes in evolution, so even though genetic factors are the main cause, environmental factors such as insufficient dietary supplementations of fatty acids, exposures to infections, various chemicals or drugs can change gene expression and contribute to autism.


'/>"/>

Contact: Gloria Suhasini
suhasini@yorku.ca
416-736-2100 x22094
York University
Source:Eurekalert

Related medicine news :

1. Asha Nutrition Sciences Launches Pre-sales Fundraising Campaign to Promote Tailored Lipids, LipiLife
2. Tomato therapy: Engineered veggies target intestinal lipids, improve cholesterol
3. Study finds few patients with newly-diagnosed hyperlipidemia receive recommended thyroid screening
4. POC Abused Drugs & Lipid Testing Market Analysis For US, Germany & Spain in New Research Reports at RnRMarketResearch.com
5. Faculty List for Continuing Medical Education (CME) Conference 17th Annual Conference on Hypertension, Diabetes and Dyslipidemia Released by Continuing Education Company
6. Researchers show that lipid nanoparticles are ideal for delivering genes and drugs
7. Statins have potential to treat an autoimmune clotting disorder called antiphospholipid syndrome
8. New medication shows promise as lipid-lowering therapy for rare cholesterol disorder
9. New lipid screening guidelines for children overly aggressive, UCSF researchers say
10. Lipid helps cells find their way by keeping their antennae up
11. Spinal cord injury researchers win Apple Award for article on niacin for dyslipidemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... ... 2017 , ... Diagnotes, an Indianapolis-based digital healthcare communication company, ... secure clinical communication platform. The platform allows clinicians to easily escalate their preferred ... urgency of a situation. , “We know from our daily lives that ...
(Date:5/23/2017)... ... , ... Orbita’s Nathan Treloar will discuss the role of voice-powered healthcare applications ... Connected Health and IoT: Technology Innovators and Disruption , the workshop is part of ... research and consulting firm specializing in emerging consumer technology products and services. , ...
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... ... now receive treatment using the SPEED System™ Orthodontics, with or without a referral, ... orthodontist in El Segundo, CA, who is skilled in providing patients with ...
(Date:5/23/2017)... ... May 23, 2017 , ... Patients in need of ... Angela Cotey’s practice to schedule an appointment, with or without a referral. Dr. Cotey ... pulpotomy treatments to pediatric patients as a healthy alternative to a tooth extraction. , ...
(Date:5/22/2017)... Kisco, NY (PRWEB) , ... May 22, 2017 , ... ... are urged to receive relaxing sedation dentistry in Mt. Kisco, NY from Advanced Endodontics ... be administered for a variety of treatments. One or more sedation methods may be ...
Breaking Medicine News(10 mins):
(Date:5/22/2017)... N.Y. , May 22, 2017  Lilac ... treatment Gene-Eden-VIR/Novirin, announces the launch of a ... English, the results of a clinical study that ... year treatment with Gene-Eden-VIR/Novirin in individuals suffering from ... to note that there are no other treatments ...
(Date:5/18/2017)... , May 18, 2017  Two Bayer U.S. ... Association (HBA) during its recent 28 th ... City.  The event showcases HBA,s longstanding mission of furthering ... of healthcare. Cindy Powell-Steffen , senior ... U.S. Radiology division, and Libby Howe , a ...
(Date:5/15/2017)... May 15, 2017  Amy Baxter MD, chief executive ... in noninvasive pain relief, was awarded a 2017 Top ... Baxter was recognized at the MM&M Top 40 Healthcare ... City on May 10, 2017. The dinner ... industry go "beyond the pill."  "Innovation goes ...
Breaking Medicine Technology: