Navigation Links
Lipid helps cells find their way by keeping their 'antennae' up
Date:7/9/2012

AUGUSTA, Ga. A lipid that helps lotion soften the skin also helps cells find and stay in the right location in the body by ensuring they keep their "antennae" up, scientists report.

Each cell has an antenna, or cilium, that senses the environment then determines where to go and what to do when it arrives, said Dr. Erhard Bieberich, biochemist at the Medical College of Georgia at Georgia Health Sciences University.

"A cell is blind; it does not see, it does not feel; it doesn't know where it is," Bieberich said. "It needs to have an organelle that senses where it is in space in order to go where it wants and needs to go."

That kind of direction helps keep brain cells, for example, from wandering off to the feet and vice versa. It's enabled by growth factor receptors on the antennae that are attracted to growth factors secreted by cells that already have found their way. Once cells are situated, the antennae help them respond to nearby signals, such as helping kidney cells sense when to void, said Bieberich, corresponding author of the study in Molecular Biology of the Cell.

His team has shown that the lipid ceramide helps cells keep this organelle or antenna from retracting by inhibiting the enzyme, histone deacetylase 6 or HDAC6.

Antennae must retract for cells to divide and activating HDAC6 enables that occasional necessity, such as during development or when more skin or gastrointestinal cells are needed to replace normal turnover. Interestingly, some of the most rapidly dividing cells, cancer cells, "abuse" HDAC for their purposes; they also suppress ceramide, which is known to induce cell suicide, Bieberich said.

Ceramide is really quite the multi-tasker. Bieberich's team reported in 2007 in the Journal of Biological Chemistry that in the earliest days of development, it helps orient stem cells to which way is up and find their place in a lineup that is important for the genesis of an embryo. Three years earlier the scientists showed the lipid teams up with the protein PAR-4 to eliminate useless cells in developing brains.


'/>"/>
Contact: Greg Deriso
gderiso@georgiahealth.edu
706-721-7134
Georgia Health Sciences University
Source:Eurekalert  

Related medicine news :

1. Spinal cord injury researchers win Apple Award for article on niacin for dyslipidemia
2. Device converting images into music helps individuals without vision reach for objects in space
3. TB treatment paradox: Mouse studies show bodys own response helps TB bacteria survive
4. New mouse model helps explain gene discovery in congenital heart disease
5. Study suggests touch therapy helps reduce pain, nausea in cancer patients
6. Stanley Cup Champion Goalie’s Trainer Helps Reduce Injury
7. Brain structure helps guide behavior by anticipating changing demands
8. Mayo Clinic: Molecule thought cancer foe actually helps thyroid tumors grow
9. How MyTownInsurance.com Helps Insurance Carriers Manage their Loss Exposure through On-Line Marketing
10. Discovery helps mice beat urinary tract infections
11. New Jersey Gym Helps People Train For Mud Runs!
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Lipid helps cells find their way by keeping their 'antennae' up
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned by ... to enhance the health of felines. The formula is all-natural and is made from ... the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract ...
(Date:6/25/2016)... FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial ... Plant City Observer , brings up a new, often overlooked aspect of head lice: the ... closing for fumigation is not a common occurrence, but a necessary one in the event ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary ... Work award to iHire in recognition of their exemplary accomplishments in worksite health promotion. ... Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire ...
(Date:6/24/2016)... ... ... in a crisis. Her son James, eight, was out of control. Prone to extreme mood ... something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a ... children and say he was going to kill them. If we were driving on ...
(Date:6/24/2016)... ... ... BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a ... an hour by 2020 and then adjusting it yearly to increase at the same rate ... assure the wage floor does not erode again, and make future increases more predictable. , ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... June 27, 2016  VMS Rehab Systems, Inc. ( ... take whatever measures required to build a strong and ... is currently listed on the OTC Markets-pink current trading ... and CEO, "We are seeing an anomaly in market ... not only by the Company, but shareholders and market ...
(Date:6/24/2016)... 2016  Collagen Matrix, Inc., ("Collagen Matrix") the ... of collagen and mineral based medical devices for ... Bill Messer has joined the company as ... the growing portfolio of oral surgery, neurosurgery, orthopaedic ... joins the Collagen Matrix executive team as an ...
(Date:6/24/2016)... , June 24, 2016 ... has announced the addition of the " Global ... This report ... provides an updated review, including its applications in various ... total market, which includes three main industries: pharmaceutical and ...
Breaking Medicine Technology: