Navigation Links
Lipid helps cells find their way by keeping their 'antennae' up
Date:7/9/2012

AUGUSTA, Ga. A lipid that helps lotion soften the skin also helps cells find and stay in the right location in the body by ensuring they keep their "antennae" up, scientists report.

Each cell has an antenna, or cilium, that senses the environment then determines where to go and what to do when it arrives, said Dr. Erhard Bieberich, biochemist at the Medical College of Georgia at Georgia Health Sciences University.

"A cell is blind; it does not see, it does not feel; it doesn't know where it is," Bieberich said. "It needs to have an organelle that senses where it is in space in order to go where it wants and needs to go."

That kind of direction helps keep brain cells, for example, from wandering off to the feet and vice versa. It's enabled by growth factor receptors on the antennae that are attracted to growth factors secreted by cells that already have found their way. Once cells are situated, the antennae help them respond to nearby signals, such as helping kidney cells sense when to void, said Bieberich, corresponding author of the study in Molecular Biology of the Cell.

His team has shown that the lipid ceramide helps cells keep this organelle or antenna from retracting by inhibiting the enzyme, histone deacetylase 6 or HDAC6.

Antennae must retract for cells to divide and activating HDAC6 enables that occasional necessity, such as during development or when more skin or gastrointestinal cells are needed to replace normal turnover. Interestingly, some of the most rapidly dividing cells, cancer cells, "abuse" HDAC for their purposes; they also suppress ceramide, which is known to induce cell suicide, Bieberich said.

Ceramide is really quite the multi-tasker. Bieberich's team reported in 2007 in the Journal of Biological Chemistry that in the earliest days of development, it helps orient stem cells to which way is up and find their place in a lineup that is important for the genesis of an embryo. Three years earlier the scientists showed the lipid teams up with the protein PAR-4 to eliminate useless cells in developing brains.


'/>"/>
Contact: Greg Deriso
gderiso@georgiahealth.edu
706-721-7134
Georgia Health Sciences University
Source:Eurekalert  

Related medicine news :

1. Spinal cord injury researchers win Apple Award for article on niacin for dyslipidemia
2. Device converting images into music helps individuals without vision reach for objects in space
3. TB treatment paradox: Mouse studies show bodys own response helps TB bacteria survive
4. New mouse model helps explain gene discovery in congenital heart disease
5. Study suggests touch therapy helps reduce pain, nausea in cancer patients
6. Stanley Cup Champion Goalie’s Trainer Helps Reduce Injury
7. Brain structure helps guide behavior by anticipating changing demands
8. Mayo Clinic: Molecule thought cancer foe actually helps thyroid tumors grow
9. How MyTownInsurance.com Helps Insurance Carriers Manage their Loss Exposure through On-Line Marketing
10. Discovery helps mice beat urinary tract infections
11. New Jersey Gym Helps People Train For Mud Runs!
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Lipid helps cells find their way by keeping their 'antennae' up
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
(Date:6/25/2016)... ... , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors ... Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green ... hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train ...
(Date:6/25/2016)... ... ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter of ... too high can result in disappointment, perhaps even self-loathing. However, those who set the ... Research from PsychTests.com reveals that behind the tendency to set low expectations ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016 The Academy of Managed Care ... that would allow biopharmaceutical companies to more easily ... make formulary and coverage decisions, a move that addresses ... medicines. The recommendations address restrictions in the ... the drug label, a prohibition that hinders decision makers ...
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... "The World Market for Companion Diagnostic Tests" report to ... World Market for Companion Diagnostics The World ... diagnostic and personalized medicine diagnostics. Market analysis in the report ... Diagnostics Test Market (In Vitro Diagnostic Kits) by Region (N. ...
(Date:6/24/2016)... , Belgium , June 24, ... VNRX), today announced the appointment of Dr. ... Directors as a Non-Executive Director, effective June 23, ... Audit, Compensation and Nominations and Governance Committees.  As ... Futcher will provide independent expertise and strategic counsel ...
Breaking Medicine Technology: