Navigation Links
Lipid helps cells find their way by keeping their 'antennae' up
Date:7/9/2012

AUGUSTA, Ga. A lipid that helps lotion soften the skin also helps cells find and stay in the right location in the body by ensuring they keep their "antennae" up, scientists report.

Each cell has an antenna, or cilium, that senses the environment then determines where to go and what to do when it arrives, said Dr. Erhard Bieberich, biochemist at the Medical College of Georgia at Georgia Health Sciences University.

"A cell is blind; it does not see, it does not feel; it doesn't know where it is," Bieberich said. "It needs to have an organelle that senses where it is in space in order to go where it wants and needs to go."

That kind of direction helps keep brain cells, for example, from wandering off to the feet and vice versa. It's enabled by growth factor receptors on the antennae that are attracted to growth factors secreted by cells that already have found their way. Once cells are situated, the antennae help them respond to nearby signals, such as helping kidney cells sense when to void, said Bieberich, corresponding author of the study in Molecular Biology of the Cell.

His team has shown that the lipid ceramide helps cells keep this organelle or antenna from retracting by inhibiting the enzyme, histone deacetylase 6 or HDAC6.

Antennae must retract for cells to divide and activating HDAC6 enables that occasional necessity, such as during development or when more skin or gastrointestinal cells are needed to replace normal turnover. Interestingly, some of the most rapidly dividing cells, cancer cells, "abuse" HDAC for their purposes; they also suppress ceramide, which is known to induce cell suicide, Bieberich said.

Ceramide is really quite the multi-tasker. Bieberich's team reported in 2007 in the Journal of Biological Chemistry that in the earliest days of development, it helps orient stem cells to which way is up and find their place in a lineup that is important for the genesis o
'/>"/>

Contact: Greg Deriso
gderiso@georgiahealth.edu
706-721-7134
Georgia Health Sciences University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Spinal cord injury researchers win Apple Award for article on niacin for dyslipidemia
2. Device converting images into music helps individuals without vision reach for objects in space
3. TB treatment paradox: Mouse studies show bodys own response helps TB bacteria survive
4. New mouse model helps explain gene discovery in congenital heart disease
5. Study suggests touch therapy helps reduce pain, nausea in cancer patients
6. Stanley Cup Champion Goalie’s Trainer Helps Reduce Injury
7. Brain structure helps guide behavior by anticipating changing demands
8. Mayo Clinic: Molecule thought cancer foe actually helps thyroid tumors grow
9. How MyTownInsurance.com Helps Insurance Carriers Manage their Loss Exposure through On-Line Marketing
10. Discovery helps mice beat urinary tract infections
11. New Jersey Gym Helps People Train For Mud Runs!
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Lipid helps cells find their way by keeping their 'antennae' up
(Date:7/31/2015)... , ... July 31, 2015 , ... ... of a wide variety of nutritional and wellness products, announced the addition of ... specializes in massage therapy, active isolated stretching and the prevention and rehabilitation of ...
(Date:7/31/2015)... MN (PRWEB) , ... July 31, 2015 , ... ... deal. The same logic applies when purchasing disability insurance, where price is an ... Secura Consultants, along with a leading insurance carrier, offers the Preferred Producer Multi-Life ...
(Date:7/30/2015)... (PRWEB) , ... July 30, 2015 , ... Dale Sky ... United States, will speak at the International Cannabis Professionals Expo held at the Caribe ... , The International Cannabis Professionals Expo is the largest medical cannabis expo ...
(Date:7/30/2015)... (PRWEB) , ... July 31, 2015 , ... Committed to ... to action by asking community members to contribute to the College’s “My Brother’s Keeper ... of our young people stay on track. Providing the support they need to think ...
(Date:7/30/2015)... , ... July 30, 2015 , ... OSF Healthcare ... results from the 2015 Most Wired Survey conducted by Hospitals & Health Networks. This ... system owned and operated by The Sisters of the Third Order of St. ...
Breaking Medicine News(10 mins):Health News:NPI Welcomes Vincent Aquilino to Board of Directors 2Health News:Secura Consultants Gives Advisers Competitive New Edge with Multi-Life Discount Program 2Health News:Finally…First Ever Professional Training Event for Doctors and Nurses Wanting to Offer Medical Marijuana Recommendations to Patients 2Health News:Finally…First Ever Professional Training Event for Doctors and Nurses Wanting to Offer Medical Marijuana Recommendations to Patients 3Health News:Finally…First Ever Professional Training Event for Doctors and Nurses Wanting to Offer Medical Marijuana Recommendations to Patients 4Health News:Finally…First Ever Professional Training Event for Doctors and Nurses Wanting to Offer Medical Marijuana Recommendations to Patients 5Health News:Mercy College a “My Brother’s Keeper” Community 2Health News:Mercy College a “My Brother’s Keeper” Community 3Health News:OSF HealthCare Named One of the Most Wired Systems 2Health News:OSF HealthCare Named One of the Most Wired Systems 3
... IRVINE, Calif., Dec. 5 ISTA Pharmaceuticals, Inc. (Nasdaq: ... President of Corporate Development, will participate in a panel discussion ... RBC Capital Markets Healthcare Conference. The panel will begin at ... New York. , , ...
... Closer look at tumors boosts chances for those denied under ... News) -- Many patients with liver cancer who don,t meet ... candidates for liver transplantation, according to an Italian study. , ... single tumor of 5 centimeters or less in diameter, or ...
... American adults do not engage in sufficient levels of daily exercise. Treadmill ... levels of inactivity. , ... Phoenix, AZ (Vocus) December 5, 2008 -- ... and Prevention (CDC) 2008 Physical Activity Guidelines for Americans released today showed ...
... LISLE, Ill., Dec. 5 Following a USGS study ... the publicly treated,water that was tested, the Water Quality ... , According to ... of about,130 man-made chemicals were not removed by public ...
... CompanyDissolvedRetiree Health Care Payments , , ... who are members of the Teamsters Union, held a rally yesterday ... 600 Teamster workers have been forced out on strike at Oak ... cut off health care benefits from retirees. , ...
... In recognition of the best,Florida nonprofits successfully addressing ... a Healthy Florida, the philanthropic affiliate,of Blue Cross and ... Award honorees at a ceremony in Orlando. , ... ) , ...
Cached Medicine News:Health News:New Criteria Could Expand Number of Liver Transplant Candidates 2Health News:Exceeding the Government's Minimum Health Guidelines with a Treadmill Desk 2Health News:Exceeding the Government's Minimum Health Guidelines with a Treadmill Desk 3Health News:Chemicals Remain in Most Treated Water, Says Report 2Health News:Striking Oak Harbor Employees Honor Retirees 2Health News:Florida's Top Health Care Nonprofits Honored With 2008 Sapphire Awards 2
(Date:7/30/2015)... , July 30, 2015  Growth of the U.S. ... they bring former prescription users to the OTC market. ... forecasts robust Rx-to-OTC switch activity over the next ... along with many new brands entering the market into ... the next five years (even those with low to ...
(Date:7/30/2015)...  Medimetriks Pharmaceuticals, Inc. announced today that its ... study for Ozenoxacin, a novel bactericidal non-fluorinated quinolone ... U.S. rights to Ozenoxacin 1% cream.  ... with an emphasis on U.S. patients, involved 412 ... older with a clinical diagnosis of bullous or ...
(Date:7/30/2015)... , July 30, 2015 Vermillion, ... on gynecologic disease, announced today it will ... after the market close on Thursday, August ... call and webcast at 4:30pm Eastern.Conference Call ... at 4:30pm Eastern/1:30pm Pacific  Domestic: ...
Breaking Medicine Technology:Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 2Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 3Medimetriks Pharmaceuticals, Inc. Announces Completion of the Second Successful Pivotal Phase III Study for Ozenoxacin 2Medimetriks Pharmaceuticals, Inc. Announces Completion of the Second Successful Pivotal Phase III Study for Ozenoxacin 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: