Navigation Links
Lipid blocks influenza infection
Date:11/9/2011

A natural lipid in the fluid lining the lungs inhibits influenza infections in both cell cultures and mouse models, according to researchers at National Jewish Health. These findings, combined with previous studies demonstrating effectiveness against respiratory syncytial virus, suggest that the molecule, known as POPG, may have broad antiviral activity.

"Supplemental POPG could be an important, inexpensive and novel approach for the prevention and treatment of influenza and other respiratory virus infections," said Dennis Voelker, PhD, Professor of Medicine, and senior author in the report, published online in the American journal of Respiratory Cell and Molecular Biology.

Influenza infects millions of people across the globe, killing 500,000 each year. Vaccines are highly effective, but must be reformulated each year to counter new viral strains. Two classes of drug are currently available to treat established influenza infections, although widespread resistance has developed against one class and is developing against the other.

Several proteins that inhibit viral activity have been identified in the fluid lining the lungs. Until recently, however, the antiviral role of POPG (palmitoyl-oleoyl-phosphatidylglycerol) has been unknown. Previous research by Dr. Voelker, Mari Numata, MD, PhD, and their colleagues demonstrated that POPG reduces inflammation in the lung and prevents infection by respiratory syncytial virus.

In the most recent study, the researchers looked at the ability of POPG to inhibit infection by two strains of influenza, H1N1-PR8 and H3N2. They found that POPG suppressed inflammatory responses, viral propagation and cell death normally associated with influenza infection.

In mice, POPG also suppressed viral infection and replication, and markedly reduced the inflammatory response to the virus. There were no observable deleterious effects of POPG in animal behavior or histopathology.

"Lipids such as POPG, off
'/>"/>

Contact: William Allstetter
allstetterw@njhealth.org
303-398-1002
National Jewish Health
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New drug candidate reduces blood lipids
2. ACCORD: Intensive BP, combined lipid therapies do not help adults with diabetes
3. International summit held to stimulate collaborative clinical research on antiphospholipid syndrome
4. Researchers identify the metabolic signaling pathway responsible for dyslipidemia
5. South Carolina researcher wins Avanti Award in Lipids
6. CME on atrial fibrillation, interventional cardiology and lipids online at CardioCareLive
7. New advances in lipid genetics lead to better detection and prevention of major diseases
8. New study shows soy protein improves lipid profile in healthy individuals
9. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
10. Researchers create first molecule-blocks key component of cancer genes on-off switch
11. Researchers create first molecule blocks key component of cancer genes on-off switch
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... 21, 2014 C8 lawsuits move forward ... as the list of 20 possible C8 lawsuits ... to six, reports Wright & Schulte LLC. Court records ... almost 2500 C8 lawsuits filed that represent individuals who ... as a result of being exposed to water contaminated ...
(Date:9/20/2014)... (PRWEB) September 21, 2014 Recently, iFitDress.com, a ... selection of beautiful party dresses . In addition, the ... the main aim of the promotion is to benefit all ... outfits in its online store now. , Along with ... of graceful items. It has recently released its new sexy ...
(Date:9/20/2014)... 2014 Weight Destroyer , a ... expert Michael Wren that has already helped tens of ... health conditions like high blood pressure, high cholesterol, and ... prompting an investigative review. , “Weight Destroyer is ... down by showing people what is truly effective when ...
(Date:9/20/2014)... (PRWEB) September 20, 2014 The Villa ... Villa del Palmar Cabo San Lucas, Villa La Estancia ... to Hurricane Odile, with plans to welcome guests back ... As of Sept. 19, all members and guests of ... thanks to a coordinated effort with government authorities. ...
(Date:9/20/2014)... September 20, 2014 Ticket Down ... tickets . This popular ticket exchange is offering their ... , The 2015 schedule of tours is beginning to fill ... announced their plans to hit the road, including 21-year-old pop ... announced the “Honeymoon Tour,” which will take her to 25 ...
Breaking Medicine News(10 mins):Health News:C8 Lawsuit Claims Move Forward as Six Possible Cases for Bellwether Trials Selected in DuPont Water Contamination Lawsuits, Reports Wright & Schulte LLC 2Health News:C8 Lawsuit Claims Move Forward as Six Possible Cases for Bellwether Trials Selected in DuPont Water Contamination Lawsuits, Reports Wright & Schulte LLC 3Health News:C8 Lawsuit Claims Move Forward as Six Possible Cases for Bellwether Trials Selected in DuPont Water Contamination Lawsuits, Reports Wright & Schulte LLC 4Health News:Beautiful Party Dresses For Autumn Unveiled By iFitDress.com 2Health News:Weight Destroyer: Review Exposes Michael Wren’s Guide to Effective Weight Loss and Improved Health 2Health News:Weight Destroyer: Review Exposes Michael Wren’s Guide to Effective Weight Loss and Improved Health 3Health News:Villa Group Resorts in Cabo Largely Unharmed, Plan to Re-open Early October 2Health News:Ariana Grande Tickets in Phoenix, Los Angeles, Anaheim, San Jose, Seattle, and Vancouver Go on Sale Today 2Health News:Ariana Grande Tickets in Phoenix, Los Angeles, Anaheim, San Jose, Seattle, and Vancouver Go on Sale Today 3
... Permanente has,announced the promotion of Greg Cleary ... as director, Membership,Administration. He joined Kaiser Permanente ... is responsible for overseeing Kaiser Permanente,s,Membership Administration ... Texas. These,locations include more than 800 employees ...
... 15 IDEXX Laboratories,Inc. (Nasdaq: IDXX ), announced ... by the Company of an additional four million,shares of ... will be made in the open market or in ... shares remaining as of,December 31, 2007, under a previous ...
... found, health officials still recommend inoculation , , FRIDAY, Feb. ... in virtually every state, and many of the infections ... this year,s influenza vaccine, U.S. health officials said Friday. ... in the early part of the season, since January, ...
... for TRIA, the first hair removal ... U.S. home-based beauty device market, NEW YORK, Feb. ... Communications as its U.S. agency of record for,TRIA, the ... beauty,device market., SpectraGenics, Inc. is a leader in ...
... leading global,provider of clinical documentation technology and services, ... board of directors., Tsai is a principal ... Co., one of the world,s largest private equity ... hold the,majority ownership of Spheris., Tsai,s election ...
... Beck Says: ,Barack Will Change America, WASHINGTON, ... service workers endorsed Sen. Barack Obama for,president today, ... best plan,and best strategy to lead the country ... the Service Employees International Union endorsed Obama to,achieve ...
Cached Medicine News:Health News:Greg Cleary Named Vice President, Membership Administration for Kaiser Permanente 2Health News:Flu Widespread in U.S., but Vaccine Is Poor Match 2Health News:Spectragenics Names Rpr Marketing Communications Agency of Record 2Health News:Spheris Elects New Board Member 2Health News:SEIU Members Endorse Sen. Barack Obama 2
(Date:9/19/2014)... SOUTH EASTON, Mass. , Sept. 19, 2014 ... the "Company") today announced it has received and ... throughput Barozyme HT48 instruments and has begun to ... believes the first instrument will be ready for ... will be built and released at a rate ...
(Date:9/19/2014)... , September 19, 2014 ... IQ den äußerst erfolgreichen Serialisierungs-Countdown-Kalender aktualisiert, der jetzt ... interaktive PDF, verfügbar unter pharmaserialisation.com , zeigt ... sie jeweils in Kraft treten. Für ... nicht länger um das "ob", sondern darum, "wann" ...
(Date:9/19/2014)... CAMBRIDGE, Mass. , Sept. 19, 2014 ... a provider of advanced cancer genome analysis and ... leader in discovering and developing highly selective kinase ... first-ever comprehensive genomic study of malignant mixed Mullerian ... the female reproductive system, also known as carcinosarcoma. ...
Breaking Medicine Technology:Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 2Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 3Pharma IQ stellt weltweite Serialisierungsfristen in seinen Countdown-Kalender 2014 - 2018 2First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 2First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 3First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 4
... Delivers Unprecedented Specificity for ... Diagnosing ... Medical Solutions,Diagnostics (http://www.siemens.com/diagnostics ) announced that it has ... rights to develop an,automated stimulating TSH receptor antibody (TRAb) ...
... more effective than,tamoxifen at preventing breast cancer recurrence ... with hormone-responsive cancers. In addition, the increased,risk of ... being treated with,anastrozole disappears after treatment ends., ... Antonio Breast Cancer,Symposium, Professor John Forbes of the ...
Cached Medicine Technology:Siemens Medical Solutions Diagnostics Inks Agreement with KreLo Medical Diagnostics to Expand Thyroid Immunoassay Menu 2Siemens Medical Solutions Diagnostics Inks Agreement with KreLo Medical Diagnostics to Expand Thyroid Immunoassay Menu 3Anastrozole Confirmed Superior in Breast Cancer Prevention 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: