Navigation Links
Linking vascular inflammation to obesity and atherosclerosis
Date:5/6/2014

A study in The Journal of Experimental Medicine shows that IκB kinase β (IKKβ) functions in smooth muscle cells to regulate vascular inflammatory responses and atherosclerosis development.

Inflammatory responses are the driving force of atherosclerosis, a process that involves the hardening and thickening of artery walls due to excess fatty deposits. IKKβ is a central coordinator of inflammatory responses that has been implicated in vascular diseases, but its role in atherosclerosis has been unclear.

Now, Changcheng Zhou and colleagues from the University of Kentucky show that deficiency of IKKβ in smooth muscle cells decreases vascular inflammation and atherosclerosis development in mice. Surprisingly, the lack of IKKβ also blocks the differentiation of fat cells and causes an accumulation of body fat precursor cells, thus protecting the animals from diet-induced obesity. These novel findings suggest that the kinase acts as a regulator of fat cell differentiation. The use of IKKβ inhibitors may therefore provide an innovative treatment for atherosclerosis, obesity, and metabolic disorders.


'/>"/>

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert  

Page: 1

Related medicine news :

1. Scientists find key steps linking dietary fats and colon cancer tumor growth
2. Linking risk factors and disease origins in breast cancer
3. New Studies Linking Environmental Toxins to Infertility Validate Benefits of Fairhaven Health's FertileDetox
4. Pradaxa Lawsuit News: Bernstein Liebhard LLP Notes New Study Linking Pradaxa to Increased Heart Attack Risk
5. Stryker Hip Lawsuit News: Bernstein Liebhard LLP Comments on Research Linking Femoral Stem Corrosion at Modular-Neck Junction with Local Soft Tissue Destruction
6. Rottenstein Law Group LLP Responds to Study Linking Pradaxa Side Effects with Potential Mortality Risks
7. Zocor Side Effects Update: Bernstein Liebhard LLP Comments on New Study Linking Kidney Problems to High Doses of Zocor, Other Statins
8. New discoveries linking gut bacteria with cholesterol metabolism give hope for the future
9. HypothyroidMom.com Reveals Research Linking Hypothyroidism to the Deadliest Diseases of Our Time
10. Atlanta LASIK Surgeon Publishes Response to New Study on Blinking
11. MyBloodWorks Creator Glen Ogle Comments on New Study Linking Hypertension During Pregnancy to Later Heart Trouble
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Linking vascular inflammation to obesity and atherosclerosis
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned ... developed to enhance the health of felines. The formula is all-natural and is made ... in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library ... City Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ... for fumigation is not a common occurrence, but a necessary one in the event that ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... On Friday, ... presented a Bronze Wellness at Work award to iHire in recognition of their exemplary ... part of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
(Date:6/24/2016)... NY (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin ... companies that call for a minimum wage raise to $12 an hour by 2020 and ... This will restore the lost value of the minimum wage, assure the wage floor does ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016 The Academy of Managed Care ... that would allow biopharmaceutical companies to more easily ... make formulary and coverage decisions, a move that addresses ... medicines. The recommendations address restrictions in the ... the drug label, a prohibition that hinders decision makers ...
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
(Date:6/23/2016)... -- MedSource announced today that it has selected Datatrial,s ... choice.  This latest decision demonstrates MedSource,s commitment to ... by offering a state-of-the-art electronic data capture (EDC) ... the EDC platform of choice in exchange for ... long been a preferred EDC platform by our ...
Breaking Medicine Technology: