Navigation Links
Link found between common sexual infection and risk of aggressive prostate cancer
Date:9/9/2009

A new study from Harvard School of Public Health (HSPH) and Brigham and Women's Hospital researchers has found a strong association between the common sexually transmitted infection, Trichomonas vaginalis, and risk of advanced and lethal prostate cancer in men.

The study appears online on September 9, 2009, on the Journal of the National Cancer Institute website and will appear in a later print edition.

"Prostate cancer is the most common cancer among men in western countries, and the second leading cause of cancer-specific mortality. Identifying modifiable risk factors for the lethal form of prostate cancer offers the greatest opportunity to reduce suffering from this disease," said Jennifer Stark, an HSPH researcher and lead author of the study.

One potential risk factor is inflammation, which appears to play an important role in the development and progression of prostate cancer, but the source of inflammation of the prostate is not clear. Trichomonas vaginalis, which infects an estimated 174 million people globally each year and is the most common non-viral sexually transmitted infection, can infect the prostate and could be a source of inflammation. With respect to prostate cancer prevention, it is noteworthy that up to three-quarters of men infected with Trichomonas vaginalis may not realize they are infected, since they may not have any symptoms.

A previous study had found an association between risk of prostate cancer and Trichomonas vaginalis infection, but was not large enough to determine if there was a link between the infection and advanced and lethal disease.

In the present study, the researchers analyzed blood samples from 673 men with prostate cancer who were participants in the Physicians' Health Study and compared infection status based on antibody levels to 673 control subjects who were not diagnosed with prostate cancer. The blood samples were collected in 1982, on average a decade before cancer diagnosis.

The results showed that Trichomonas vaginalis infection was associated with a more than two-fold increase in the risk of prostate cancer that was advanced stage at diagnosis, and a nearly three-fold increase in prostate cancer that would result in death.

"The fact that we found a strong association between serologic evidence of infection with Trichomonas vaginalis, a potentially modifiable risk factor, and risk of advanced and lethal disease represents a step forward in prostate cancer, especially given that so few risk factors for aggressive prostate cancer have been identified," said Lorelei Mucci, assistant professor in the department of epidemiology at HSPH and senior author of the study.

The authors note that further research needs to be done to confirm the findings. If confirmed, the findings from the large-scale, prospective study would identify infections as one of the few known modifiable factors for aggressive prostate cancer. Moreover, since the infection is easily treated with an inexpensive antibiotic regimen, the results from the study suggest that prevention or early treatment of Trichomonas vaginalis infection could be a target for prostate cancer prevention.


'/>"/>

Contact: Todd Datz
tdatz@hsph.harvard.edu
617-432-3952
Harvard School of Public Health
Source:Eurekalert

Related medicine news :

1. New type of adult stem cells found in the prostate may be involved in prostate cancer development
2. Peter G. Peterson Foundation Releases The Lewin Group Study Showing Current House Health Care Reform Proposal Would Lead to Expanded Coverage and Higher Costs
3. Alzheimers Drug Discovery Foundation Funds Abiant, Inc. to Develop a Positron Emission Tomography (PET) Imaging Diagnostic for Alzheimers Disease
4. Safe Blood for Africa Foundation and Hema-Quebec Sign Far-Reaching Agreement
5. COSHAR Foundation Promotes Importance of Timely Childhood Immunization at Black Family Reunion Celebration in Washington, D.C.
6. Founder of Curidium Launches Elixior, an Advisory Company Focused on the Development and Growth of Innovative Personalized Medicine Businesses
7. Migraine Research Foundation Announces Winners of 2009 Research Grants
8. The Sebastian Ferrero Foundation Receives a $5 Million Gift From Google Executive for Childrens Hospital
9. Back to School Brings Risks to Young Drivers; Traffic Crashes Leading Cause of Teen Death, Says National Road Safety Foundation
10. Skin Cancer Worrying You? Us too, Which Is Why Cerjo-USA Is Helping the Skin Cancer Foundation
11. Regence Foundation Awards Nearly $250,000 in Grants to Northwest Nonprofits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... ... May 27, 2016 , ... Aimed at nurses ... human interest stories, courtesy of leaders in the nursing and health care industry. ... from leading advocates and associations—namely Jones & Bartlett Learning. , Jones & Bartlett ...
(Date:5/27/2016)... ... ... With a team of certified experts, Validation Center is ... GMP accreditation, Validation Center is also a registered authority of the international system ... Validation Center is ISO17025 accredited and only offers its clients the latest technology, ...
(Date:5/26/2016)... ... May 26, 2016 , ... W.S. Badger Co. Inc ., the maker ... 2016 When Work Works Award for its use of effective workplace strategies to increase ... Works project administered by the Families and Work Institute (FWI) and the Society for ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... property (IP) to its specialty academic programs. , Answering to the increasing demand ... certificate programs in health law, and environmental and land use law. ,  , ...
(Date:5/26/2016)... ... , ... The Woodlands at John Knox Village , Florida’s first Life ... living and healing, celebrated its grand opening, today. The Woodlands at John Knox Village ... Empowered Staff. , “This is an incredibly fulfilling time for John Knox Village as ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25, 2016 ... Market by Type (3D, 2D, 4D), by Therapeutic Area ... by End User (Medical Device Manufacturers, Hospitals/ Clinics) - ... the global Medical Animation Market for the forecast period ... reach USD 301.3 Million by 2021 from USD 117.3 ...
(Date:5/25/2016)...  Zymo Research Corp. announced today the final ... that help researchers obtain the most accurate and ... rapid growth of the study of microbiomes has ... methods to improve the reproducibility and quality of ... every step of the measurement process including collection ...
(Date:5/25/2016)... 2016 As illustrated by the ... month, the numbers and momentum of cannabis in the ... the billions, more research and development push the sector ... of Legal Marijuana Markets Report  from from ArcView Market ... of the increase in sector is attributed to adult ...
Breaking Medicine Technology: