Navigation Links
Link between signaling molecules could point way to therapies for epilepsy, stroke, other diseases
Date:1/7/2011

SAN ANTONIO (Jan. 7, 2010) In the Old West, camps sent smoke signals across distances to share key developments or strategy. Likewise, two important signaling molecules communicate across nerve cells to regulate electrical and chemical activity, neuroscientists from the UT Health Science Center San Antonio reported today.

The findings in rodent models have implications for potential future treatment of epilepsy, stroke and other problems, the researchers said.

"We now have novel targets for therapeutic intervention for a range of neurological and cardiovascular diseases, including stroke, epilepsy, dementia, hypertension, mental illness and others," said senior author Mark S. Shapiro, Ph.D., professor of physiology at the Health Science Center. "This study should guide clinicians and pharmaceutical companies in developing new therapies against mental, neurological, cardiovascular or cerebrovascular diseases that afflict many millions of people."

By isolating nerve cells from rats, the San Antonio team found a relationship between signaling enzymes called phosphoinositide kinases and calcium ions. Calcium transport and levels of calcium concentrations inside nerve cells are extremely important for proper neurobiological function, Dr. Shapiro said.

In epilepsy, for example, it is thought that the hyper-excitability in the brain causes abnormal elevations of intracellular calcium ions, which is extremely toxic. Thus, epileptic seizures often predispose people to additional seizures, as the normal regulation of brain activity increasingly breaks down.

The study is in the Jan. 7 issue of the Journal of Biological Chemistry.


'/>"/>

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert

Page: 1

Related medicine news :

1. Scientists Discover How HIV Is Transmitted Between Men
2. Study reveals genetic link between mammographic density and breast cancer
3. Telenurses face conflict between what is best for patients and what services are available
4. Contrast-enhanced MRI could play a key role in differentiating between common types of arthritis
5. New tool illuminates connections between stem cells and cancer
6. Few differences in outcomes between open and laparoscopic prostate surgery
7. Study: Choice between stroke-prevention procedures influenced by patient age
8. Experts call for further research into the relationship between insulin therapy and cancer
9. Henry Ford Hospital study shows link between vitamin D, skin cancer
10. K-State professor finds link between low oxygen levels in body and cancer-aiding protein
11. Statement From Reverend Al Sharpton, Former Congressman J.C. Watts, and Dr. Gary A. Puckrein on the Meeting Between the Congressional Black Caucus and the White House
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2017)... ... July 23, 2017 , ... A 20-year-long study ... Louis, and led by the Minneapolis Veterans Administration Health Care System overwhelmingly supports growing ... disease offers very few benefits. , In the cases involved with this study, ...
(Date:7/23/2017)... ... July 23, 2017 , ... Technology ... safety and patient-provider relationships. New tools are helping patients become more actively involved ... Annual Health Care’s Most Wired® survey, released today by the American Hospital Association’s ...
(Date:7/23/2017)... ... July 23, 2017 , ... Viora Ltd., a ... US Patent No. 9,038,640 by the United States Patent and Trademark Office. The ... combination of Switching, Vacuum, and Cooling mechanisms to further increase the efficacy and ...
(Date:7/21/2017)... , ... July 21, 2017 , ... "As a doctor ... lot of pleural catheters available on the market," said an inventor from Center Valley, ... and safety for the patient." , He developed the patent-pending PLEURAL SAFE-t-STAT CATHETER KIT ...
(Date:7/21/2017)... ... July 21, 2017 , ... Roderick Crabbe Insurance, ... to families and business owners in northern Florida, is joining the First Coast ... to area adults with developmental challenges. , The First Coast YMCA offers assistance ...
Breaking Medicine News(10 mins):
(Date:7/5/2017)... , July 5, 2017   BioLife Solutions ... developer, manufacturer and marketer of proprietary clinical grade cell ... freeze media ("BioLife"), today announced that it has ... debt holder and largest shareholder, to modify its existing ... Pursuant to the modification, WAVI agreed to exchange its ...
(Date:6/30/2017)... 30, 2017 In vitro diagnostics market firm ... May, at least ten diagnostic companies have successfully completed ... offerings and a loan facility.  The size of these ... million.  Kalorama Information provides a monthly IVD Market ... Knowledge Center. ...
(Date:6/30/2017)... POINT, N.C. , June 29, 2017  Axium Pharmaceuticals Inc. ... for developing improved novel formulations and alternative dosage forms of ... ... delivery is based on our waterless self-nano emulsifying formula, which ... contact with saliva. We believe the spray will provide fast ...
Breaking Medicine Technology: