Navigation Links
Link between obesity and enhanced cancer risk elucidated
Date:1/21/2010

Epidemiological studies indicate that being overweight or obese is associated with increased cancer risk. The most dramatic effect of obesity on cancer risk has been noted for a common form of liver cancer called hepatocellular carcinoma or HCC. Modeling the effect of obesity in mice, researchers at the University of California, San Diego School of Medicine have conclusively demonstrated that obesity is tumor-promoting and have obtained evidence that this effect depends on induction of low-grade, chronic inflammation.

Their results, published January 22 by the journal Cell, may suggest novel therapy to prevent HCC development in obese men who suffer from chronic liver disease.

Michael Karin, PhD, Distinguished Professor of Pharmacology in UCSD's Laboratory of Gene Regulation and Signal Transduction, who led the study, found that obesity enhanced the development of HCC by stimulating the production of tumor-promoting cytokines interleukin-6 (Il-6) and tumor necrosis factor (TNF) that also cause chronic inflammation. Production of these signaling molecules, which are elevated in obese mice and in humans, causes inflammation of the liver and activation of a tumor-promoting transcription factor, a protein called STAT3. This protein in turn activates the formation and growth of liver cancer.

The primary role of TNF is in the regulation of immune cells, but its deregulated production can cause diseases such as rheumatoid arthritis or Crohn's disease. Ironically, while TNF was also tested for its ability to kill cancer, its chronic production was found to actually enhance tumor development.

IL-6 is known to be involved in the pathogenesis of rheumatoid arthritis, but previous work in the Karin lab has shown that IL-6 also contributes to the chronic inflammation that leads to liver cancer. HCC a devastating complication of chronic liver disease and inflammation caused by risk factors such as hepatitis B and C viruses, o
'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Comparison of obstetric outcomes between on-call and patients own obstetricians
2. Mailman School of Public Health study examines link between racial discrimination and substance use
3. New link between estrogen and breast cancer
4. Link Uncovered Between Benign Prostatic Hyperplasia and NSAIDs, Says Harvard Mens Health Watch
5. Link Between Chronic Pain and Insomnia Uncovered at PAINWeek 2007
6. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
7. Researchers discover correlation between GERD and obesity in females
8. NIH awards $10.8M to Columbia to study connection between diabetes and heart disease
9. Researchers Pinpoint Link Between Caloric Restriction and Longevity
10. Link Between Air Pollution, Stroke Gets Clearer
11. No Link Between Anti-Nausea Drug, Heart Trouble
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... (PRWEB) June 19, 2013 AquaPrint Solutions in ... Pub & Grub with a newly-designed Harley Davidson motorcycle gas ... of AquaPrint Solutions with an idea of taking a split ... the ages and transforming it into a work of art. ... Pub & Grub several toilet seats that had been dipped ...
(Date:6/19/2013)... (PRWEB) June 19, 2013 Chicago is cracking ... 31st, 48th and 50th Chicago Wards will require landlords to ... or face fines. The ordinance also makes tenants ... with all treatment requests – which often include disposing of ... control company Orkin reported that it did more bed bug ...
(Date:6/19/2013)... 2013 Fit Body Boot Camp in ... a charity boot camp in order to support Orlando resident, ... boot camp franchise hosted the Brent Can Breathe fundraiser ... 75 boot camp participants and collected over $700. , Officially ... the second fundraiser held for Orlando local Brent Snyder, 24, ...
(Date:6/19/2013)... (PRWEB) June 19, 2013 The Cancer ... the promise of cancer care for the whole patient ... at the Cancer Support Community. This inaugural event, held ... Ezekiel Emanuel, MD., Ph.D., recognition of Congress members who ... the voices of patients and families currently engaged in ...
(Date:6/19/2013)... Lake City, UT (PRWEB) June 19, 2013 ... expanded BRCA1 and BRCA2 testing service , providing ... Analysis is available individually, or as part of an ... to seventeen additional genes with known links to cancer ... CDK4, STK11, SMAD4, BMPR1A, CDH1, MET, FH, FLCN, PDGFRA, ...
Breaking Medicine News(10 mins):Health News:AquaPrint Solutions Transforms Harley Davidson Gas Tank into a Work Of Art for Poopy’s Pub & Grub 2Health News:Chicago Ordinance Requires Landlords and Tenants to Take Responsibility for Bed Bugs 2Health News:Fit Body Boot Camp in Orlando Held Successful “Brent Can Breathe” Charity Boot Camp with Proceeds Going to Support Orlando Local Brent Snyder with Cystic Fibrosis 2Health News:Keeping the Promise of Cancer Care for the Whole Patient 2Health News:Keeping the Promise of Cancer Care for the Whole Patient 3Health News:Ethigen Launches Next Generation (NGS) BRCA Testing With Expanded Hereditary Cancer Panel 2Health News:Ethigen Launches Next Generation (NGS) BRCA Testing With Expanded Hereditary Cancer Panel 3
... ... take effect. The latter will offer senior citizens low premiums never before seen with ... information and rates for the new Medicare Supplement Plan N. , ... Austin, TX (PRWEB) March 12, 2010 -- Precision Senior ...
... than on natural grass, study shows , FRIDAY, March ... likely to suffer certain types of knee and ankle ... natural grass, a new study contends. , Researchers analyzed ... found that teams playing on FieldTurf had an 88 ...
... operations for carcinoma of the rectum. Christian Schmidt et al. ... issue of Deutsches rzteblatt International ( Dtsch Arztebl ... more than 70,000 people develop colorectal carcinoma. The aim of ... on quality of life and sexual function. Data from 368 ...
... New study questions the safety of football turf; warrants further research , ... , , ... ... NEW ORLEANS , ...
... beneficial, researchers find , FRIDAY, March 12 (HealthDay News) -- ... pills: A long-term study finds that those who took ... lower risk of death than women who never took the ... generation of oral contraceptives many years ago, are likely to ...
... ... the FCCG’s HelpLine indicates that for the month of February, sports’ betting was the ... seasonal events such as March Madness, the Super Bowl and the Kentucky Derby have ... already experiencing gambling problems. , ...
Cached Medicine News:Health News:Medicare Supplement Plan N Information and Rates Now Available Through Precision Senior Marketing 2Health News:Football Injuries More Likely on Certain Artificial Turf 2Health News:More Lower Extremity, Orthopaedic-Related Injuries Occur When Playing on FieldTurf 2Health News:More Lower Extremity, Orthopaedic-Related Injuries Occur When Playing on FieldTurf 3Health News:More Lower Extremity, Orthopaedic-Related Injuries Occur When Playing on FieldTurf 4Health News:'Pill' Won't Shorten Your Life: Study 2Health News:It's March Madness and the Florida Council on Compulsive Gambling Reminds Fans they don't have to Wager to Enjoy the Game 2
(Date:6/19/2013)... , June 19, 2013 /PRNewswire/ -- Chindex International, ... American healthcare company providing services in ... Family Healthcare, a network of private hospitals and ... of its Beijing United Family Rehabilitation Hospital ("BJU ... of the United Family Healthcare ("UFH") network. On ...
(Date:6/19/2013)... , June 19, 2013   Nektar Therapeutics ... from a human abuse liability (HAL) study for NKTR-181, ... of entry into the brain.  This slow rate of entry ... the abuse of and addiction to current opioid analgesics. 1 ... was rated similar to placebo in "drug liking" and ...
(Date:6/19/2013)... June 19, 2013 Amerivet Solutions, LLC ... all branches of government from Federal to Municipal, ... their facilities to include complex metal design and ... some very complex aluminum parts for the Defense ... our capabilities to service government contracts," states ...
Breaking Medicine Technology:Chindex International, Inc. Announces Opening of Beijing United Family Rehabilitation Hospital 2Chindex International, Inc. Announces Opening of Beijing United Family Rehabilitation Hospital 3Chindex International, Inc. Announces Opening of Beijing United Family Rehabilitation Hospital 4Chindex International, Inc. Announces Opening of Beijing United Family Rehabilitation Hospital 5Nektar Therapeutics Presents Positive Data from Human Abuse Liability Study for NKTR-181, a First-in-Class Investigational Opioid to Treat Chronic Pain, at 2013 Annual Meeting of The College on Problems of Drug Dependence 2Nektar Therapeutics Presents Positive Data from Human Abuse Liability Study for NKTR-181, a First-in-Class Investigational Opioid to Treat Chronic Pain, at 2013 Annual Meeting of The College on Problems of Drug Dependence 3Nektar Therapeutics Presents Positive Data from Human Abuse Liability Study for NKTR-181, a First-in-Class Investigational Opioid to Treat Chronic Pain, at 2013 Annual Meeting of The College on Problems of Drug Dependence 4Nektar Therapeutics Presents Positive Data from Human Abuse Liability Study for NKTR-181, a First-in-Class Investigational Opioid to Treat Chronic Pain, at 2013 Annual Meeting of The College on Problems of Drug Dependence 5Nektar Therapeutics Presents Positive Data from Human Abuse Liability Study for NKTR-181, a First-in-Class Investigational Opioid to Treat Chronic Pain, at 2013 Annual Meeting of The College on Problems of Drug Dependence 6Nektar Therapeutics Presents Positive Data from Human Abuse Liability Study for NKTR-181, a First-in-Class Investigational Opioid to Treat Chronic Pain, at 2013 Annual Meeting of The College on Problems of Drug Dependence 7Nektar Therapeutics Presents Positive Data from Human Abuse Liability Study for NKTR-181, a First-in-Class Investigational Opioid to Treat Chronic Pain, at 2013 Annual Meeting of The College on Problems of Drug Dependence 8Nektar Therapeutics Presents Positive Data from Human Abuse Liability Study for NKTR-181, a First-in-Class Investigational Opioid to Treat Chronic Pain, at 2013 Annual Meeting of The College on Problems of Drug Dependence 9Amerivet Solutions Expands to Manufacture Complex Metal Designs 2
... Reportlinker.com announces that a new market research ... Glucose Monitoring Systems - Global ... to 2016 http://www.reportlinker.com/p0363030/Glucose-Monitoring-Systems---Global-Pipeline-Analysis-Opportunity-Assessment-and-Market-Forecasts-to-2016.html ... Global Pipeline Analysis, Opportunity Assessment and Market ...
... Perrigo Company (Nasdaq: PRGO; TASE) today announced that ... all of the assets of Paddock Laboratories, Inc. ("Paddock"), ... products for approximately $540 million in cash. Perrigo expects ... of the acquisition of Paddock,s assets. The net present ...
Cached Medicine Technology:Reportlinker Adds Glucose Monitoring Systems - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 2Reportlinker Adds Glucose Monitoring Systems - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 3Perrigo to Acquire Assets of Paddock Labs for $540 Million 2Perrigo to Acquire Assets of Paddock Labs for $540 Million 3Perrigo to Acquire Assets of Paddock Labs for $540 Million 4Perrigo to Acquire Assets of Paddock Labs for $540 Million 5
... The electronic, motorized rotary ... all applications of paraffin, ... hard specimens in clinical, ... These instruments display extra-ordinary ...
... new face-lifted Leica RM2125 microtome comes in ... and Leica RM2125 RT. All RM2125 versions ... avoid debris entering the precision micrometer feeding ... a two-step trimming function and specimen retraction ...
... The Leica SM2500 large scale heavy-duty sectioning system ... large sectioning techniques a real working animal. ... and hard materials such as bone or teeth ... sectioned. The wide range of accessories, specially designed ...
... Designed for biomedical and industrial applications, the ... a variety of applications in all laboratories ... to be sectioned. Its sturdy construction lends ... The safety features of the system, such ...
Medicine Products: