Navigation Links
Link between brain insulin resistance, neuronal stress in worsening Alzheimer's disease
Date:6/26/2012

PROVIDENCE, R.I. Rhode Island Hospital researcher Suzanne de la Monte, M.D., has found a link between brain insulin resistance (diabetes) and two other key mediators of neuronal injury that help Alzheimer's disease (AD) to propagate. The research found that once AD is established, therapeutic efforts must also work to reduce toxin production in the brain. The study, Dysfunctional Pro-Ceramide, ER Stress, and Insulin/IGF Signaling Networks with Progression of Alzheimer's Disease, is published in the June 22, 2012, supplement of the Journal of Alzheimer's Disease.

Alzheimer's disease is one of the most common degenerative dementias, and more than 115 million new cases are projected worldwide in the next 40 years. There is clinical and experimental evidence that treatment with insulin or insulin sensitizer agents can enhance cognitive function and in some circumstances help slow the rate of cognitive decline in AD. Alzheimer's and other neurodegenerative diseases destroy the brain until the patients finally succumb. In order to effectively halt the process of neurodegeneration, the forces that advance and perpetuate the disease, particularly with regard to the progressive worsening of brain insulin/IGF resistance, must be understood.

"Brain insulin resistance (diabetes) is very much like regular diabetes," de la Monte said. "Since the underlying problems continue to be just about the same, we believe that the development of new therapies would be applicable for all types of diabetes, including Alzheimer's disease, which we refer to as Type III diabetes."

She continued, "This study points out that once AD is established, therapeutic efforts should target several different pathwaysnot just one. The reason is that a positive feedback loop gets going, making AD progress. We have to break the vicious cycle. Restoring insulin responsiveness and insulin depletion will help, but we need to reduce brain stress and repair the metabolic
'/>"/>

Contact: Ellen Slingsby
eslingsby@lifespan.org
401-444-6421
Lifespan
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Popularity Causing Several Week Lag In Delivery Of 'Plug In' Device To Start Saving On Electricity Between 8% and 20%
2. Infants cant distinguish between large and small groups
3. Science of parenting, the link between sexism and racism, death and the supernatural, and more
4. 2 new studies show connection between sleepiness and pro-athlete careers
5. Understanding the links between inflammation and chronic disease
6. Early Study Hints at Link Between Certain Sunscreens, Endometriosis
7. First study investigating possible link between sunscreen ingredient and endometriosis
8. Study shows link between pre-pregnancy obesity and lower test scores
9. New research finds no association between white potato consumption (baked, boiled mashed) and obesity, Type 2 diabetes or systemic inflammation
10. AADR comments on review that validates association between oral health and heart health
11. Study: No link between depression, nasal obstruction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... 14, 2014 Dr. Carol Isaacson ... “Cluster Innovations in Personalized Medicine” at the CONVERGE: ... 2014. Dr. Barash and fellow panelists will ... to advance the pace of personalized medicine. ... of implementers and investors will address the dynamic ...
(Date:7/14/2014)... 2014 The high demand in ... clean energy, initiatives of associations and regulatory bodies, ... which drive the growth of the global rare ... in various direct applications ranging from permanent magnets, ... others. , North America is the second-largest region ...
(Date:7/14/2014)... Washington D.C., July 14, 2014 A recent study ... Journal of the American Academy of Child and Adolescent ... to the age of onset criterion for diagnosis of ... criterion for ADHD, previously set at 7 in DSM-IV, ... age of onset is now set at 12, rather ...
(Date:7/14/2014)... PA, July 14, 2014 The inability to ignore ... often experienced by individuals diagnosed with schizophrenia, reports a ... Psychiatry . , Our brains are usually good at ... learn and filtering out the "noise" or thoughts that ... related in part to a problem with this filtering ...
(Date:7/14/2014)... 14, 2014 Chances are those dollars in your pocket ... most bank notes in the U.S. do. Your cash also ... machine before it came out of the ATM. For more, ... chemistry facts about the almighty dollar. The video is available ... Reactions YouTube , and follow us on Twitter ...
Breaking Medicine News(10 mins):Health News:Helix Health Advisors’ Carol Isaacson Barash to Lead Panel on Cluster Innovations in Personalized Medicine at CONVERGE: Innovation Meets Health Care July 15-16, 2014. 2Health News:North America Rare Earth Metals Market is Expected to Grow at a CAGR of 8% - New Report by MicroMarket Monitor 2Health News:North America Rare Earth Metals Market is Expected to Grow at a CAGR of 8% - New Report by MicroMarket Monitor 3Health News:North America Rare Earth Metals Market is Expected to Grow at a CAGR of 8% - New Report by MicroMarket Monitor 4Health News:'Noisy' memory in schizophrenia 2
... didn,t seem to matter, study finds , TUESDAY, Oct. 6 ... a deadly form of brain tumor in adulthood, new research ... the teen years was associated with a lower risk of ... increased the chances of such malignancies. , The study appears ...
... (NYSE: LLY ) will announce its financial results for the ... will also conduct a conference call on that day with the ... , The conference call will be held from 9:00 a.m. ... can access a live webcast of the conference call through a ...
... SEATTLE, Oct. 6 While end-of-life care issues have ... reform debate, physicians in the Pacific Northwest can now ... palliative medicine and hospice care. , The new Palliative ... the state of Washington, is a cooperative effort between ...
... Youths, thinner skin makes them more susceptible to severe injury, expert ... day last year, Danette McKinney asked her husband, Shawn, to check ... the door, Shawn didn,t see their 1-year-old daughter toddle up beside ... and shrieked. , "As we were taking her to the hospital, ...
... ... PetDocsOnCall.com is a new virtual pet lover,s community with something for ... direction from practicing veterinarians and specialists. Pet owners can post non-emergency ... quickly. Best of all, PetDocsOnCall.com users can feel secure knowing the ...
... CHICAGO, Oct. 6 The Blue Cross and Blue Shield ... of Health Care Policy, today recognized six Blue Cross and ... awards for their innovative and successful approaches to improving ... in its fifth year, the BlueWorks program ...
Cached Medicine News:Health News:Exercise in Adolescence May Cut Risk of Deadly Brain Tumor 2Health News:Exercise in Adolescence May Cut Risk of Deadly Brain Tumor 3Health News:New Palliative Medicine Fellowship Created to Train Pacific Northwest Doctors in End-of-Life Care 2Health News:New Palliative Medicine Fellowship Created to Train Pacific Northwest Doctors in End-of-Life Care 3Health News:Burn Rate in Kids Has Dropped, But Still Causes Concern 2Health News:Burn Rate in Kids Has Dropped, But Still Causes Concern 3Health News:PetDocsOnCall.com Connects Pet Owners to the Largest Online Network of Practicing Veterinarians 2Health News:Blue Cross and Blue Shield Companies Honored for Innovative Programs That Help Consumers Live Healthier Lives 2
(Date:7/14/2014)... 2014  My Own Med, a mobile health connectivity ... pitch competition in the Health Technologies category. The competition ... of Las Vegas . ... the most innovative startups through a rigorous review and ... and panel of esteemed judges. Of the more than ...
(Date:7/14/2014)... CVS/pharmacy ® today announced the ... brand of 100% preservative-free vitamins and supplements and ... exclusive CVS/pharmacy store brand products. The new line ... including popular options such as probiotics, B-12, and ... also has more premium options including certified non-GMO, ...
(Date:7/14/2014)... 14, 2014 The legalization of medical and ... well as a new economic driver – that has ... out the right response to the will of the ... At a National Press Club Newsmakers news ... leading experts in the area of marijuana legalization will ...
Breaking Medicine Technology:My Own Med Selected as a Finalist for SXSW V2V's second annual V2Venture Competition 2CVS/pharmacy Launches Exclusive radiance PLATINUM Line of Preservative-Free Vitamins and Supplements 2CVS/pharmacy Launches Exclusive radiance PLATINUM Line of Preservative-Free Vitamins and Supplements 3NPC Newsmaker Program: Interpreting smoke signals from the marijuana skirmish line 2
... Colo., May 19, 2011 In response to growing concerns ... children and the recent FDA Guidance for Industry ... provider of oral liquid drug delivery syringes, is available to ... at home and in hospitals: ...
... Swissray International, Inc., a leading manufacturer of direct digital Radiography ... another ddR Formula DR system to the ... more than a decade Swissray has been the pioneer and ... ) serving hundreds of health care providers and patients with ...
Cached Medicine Technology:Medication Delivery Innovator Baxa Corporation Offers Best Practices for Administering Over-the-Counter Liquid Medicine to Babies and Toddlers 2Medication Delivery Innovator Baxa Corporation Offers Best Practices for Administering Over-the-Counter Liquid Medicine to Babies and Toddlers 3Swissray Sells Another DR System to a Large Orthopedic Practice in Florida 2
... future generations. Most gels can be dried by ... our gel dryer, covering them with wet semi-permeable ... hold the cellophane flat. Tut's Tombs also produce ... area somewhat larger than the gel to be ...
... data for future generations. Most gels can be ... plate of our gel dryer, covering them with ... them to hold the cellophane flat. Tut's Tombs ... an open area somewhat larger than the gel ...
... SE 1200 Easy Breeze Air Gel Dryer : ... cm or 24 gels 8 10 cm ... temperatures for rapid drying, or no heat for ... store smooth, transparent, dried gels. Add and remove ...
... Hoefer SE 1200 Easy Breeze Air Gel Dryer ... 25 cm or 24 gels 8 10 ... air temperatures for rapid drying, or no heat ... or store smooth, transparent, dried gels. Add and ...
Medicine Products: