Navigation Links
Limiting blood flow interruption during kidney surgery avoids chronic kidney disease
Date:6/11/2010

ROCHESTER, Minn. -- Interrupting the blood flow for more than 20 to 25 minutes during kidney cancer (http://www.mayoclinic.org/kidney-cancer/research.html) surgery leads to a greater risk for patients developing chronic kidney disease, a Mayo Clinic and Cleveland Clinic collaborative research team has found. The study was published today in the journal, European Urology.

For the retrospective study, researchers analyzed outcomes of 362 patients with only one kidney who underwent surgery for renal cortical tumors at Mayo Clinic and Cleveland Clinic between 1990 and 2008. Using a technique called warm ischemia, surgeons kept the patient's kidneys at body temperature during the partial nephrectomy. Ischemia involves cutting off the blood supply to the kidney with clamps in order to control bleeding and to keep blood from obscuring the surgeon's view of the kidney. It also allows for precise closure of the urine collecting system and the surgical opening. The median ischemia time was 21 minutes in the study and the median age of patients was 62 years.

Ischemia can cause tissue damage from a lack of oxygen and nutrients. Researchers found that each additional minute of warm ischemia is associated with a 5 to 6 percent increase in the odds of developing acute renal failure or reduced kidney functioning and is associated with a 6 percent increased risk of new onset Stage IV chronic kidney disease during long-term follow-up.

"This is the largest evaluation of warm ischemia time in patients with a single kidney who are undergoing a partial nephrectomy, combining the experiences of the Mayo Clinic and Cleveland Clinic, both leaders in the field of kidney cancer," says R. Houston Thompson, M.D., (http://www.mayoclinic.org/bio/13623818.html) Mayo Clinic urologist and the study's primary investigator. "These results suggest that every minute counts when the renal arteries and veins are clamped. When planning for the surgery, surgeons should make efforts to minimize ischemia time, especially in situations where a person only has one kidney."

"Historically, 30 minutes was considered the maximum safe duration of warm ischemia during partial nephrectomy, and other retrospective clinical studies have suggested that warm ischemia for 40 to 55 minutes is safe," says Dr. Thompson. "However, these studies included patients with two kidneys, which could mask the true effects of ischemia on renal function.

"Because each additional minute of warm ischemia invites the risk for chronic kidney problems, if longer ischemic times are unavoidable, techniques such as ice slush (cold ischemia) should be considered."

The researchers stress that the study's results do not have implications for patients treated with cold ischemia.


'/>"/>

Contact: Amy Tieder
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. Drug that restricts blood supply to prostate tumors delays disease progression
2. ASCO data show serum DNA blood tests detect cancers with high sensitivity and specificity
3. Glucose Tattoo Could Track Blood Sugar Levels for Diabetics
4. DUI Phoenix Attorney Earns Not Guilty Verdict and Hung Jury in .104 Blood Alcohol Content DUI Case
5. First paper dipstick test for determining blood type
6. Nottingham research leads to blood test for early detection of cancer
7. Blood flows differently through the brains of schizophrenic patients
8. Report Finds Control of High Blood Pressure Improving
9. Frequent Doctor Visits Help Diabetics Control Blood Pressure
10. Fewer Sugary Drinks, Less High Blood Pressure
11. A new cancer vaccine starves tumors of blood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... , ... June 25, 2016 , ... ... and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a ... area —Johnson is one of the first doctors to perform the treatment. Orthobiologics ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events ... turn to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. ... tools for healthy coping following a traumatic event. , Trauma sufferers tend to feel ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, ... Elite. The attorneys chosen by their peers for this recognition are considered among the ... Traurig Shareholders received special honors as members of this year’s Legal Elite Hall of ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their ... Award, an essay contest in which patients and their families pay tribute to a ... the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
(Date:6/24/2016)... Maryland (PRWEB) , ... June 24, 2016 , ... ... Angels is actively feeding the Frederick area economy by obtaining investment capital for ... over the past 2½ years that have already resulted in more than a ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... LAS VEGAS , June 26, 2016 ... movement to value-based care operating models within the health ... that enable greater financial efficiency , Deloitte offers ... address the key business issues impacting efficient cost optimization: ... alignment , These services facilitate better outcomes and ...
(Date:6/24/2016)... June 24, 2016 ... announced the addition of the " Global Markets ... This report focuses ... an updated review, including its applications in various applications. ... market, which includes three main industries: pharmaceutical and biotechnology, ...
(Date:6/24/2016)... , June 24, 2016 Research ... World Market for Companion Diagnostic Tests" report to their ... Market for Companion Diagnostics The World Market ... and personalized medicine diagnostics. Market analysis in the report includes ... Test Market (In Vitro Diagnostic Kits) by Region (N. America, ...
Breaking Medicine Technology: