Navigation Links
Lilly and MacroGenics Announce Licensing and Collaboration Agreement
Date:10/18/2007

in diabetes care, to develop teplizumab in multiple T-cell-mediated autoimmune diseases and to advance the molecule toward regulatory submission for recent-onset type 1 diabetes," stated Dr. Scott Koenig, president and CEO of MacroGenics. "We also look forward to working with Lilly to develop next generation CD3 product candidates to potentially treat a variety of autoimmune diseases, such as psoriasis and rheumatoid arthritis."

About Teplizumab

Teplizumab, also called MGA031, is a humanized, non-Fc receptor binding, anti-CD3 monoclonal antibody. Teplizumab binds to an epitope of the CD3- epsilon chain expressed on mature T lymphocytes and, by doing so, may modulate the pathological immunologic responses underlying multiple autoimmune diseases. Specifically, teplizumab may inhibit unwanted effector T cells and enhances beneficial regulatory T cell functions, thus promoting immune tolerance.

About the PROTEGE Trial

The PROTEGE trial, a global, pivotal Phase II/III clinical trial study, is evaluating the safety and efficacy of three teplizumab dosing regimens administered at the start of the study and again at six months in individuals with recent-onset type 1 diabetes ages 8 to 35 who are up to 12 weeks from their diagnosis.

Type 1 diabetes is an autoimmune disease in which the body's immune system attacks and destroys the insulin-producing beta cells of the pancreas. Researchers believe teplizumab may control the T lymphocytes that mediate destruction of the insulin-producing beta cells of the islets of the pancreas. In doing so, they believe teplizumab may have the ability to preserve and protect the remaining beta cells of the pancreas.

Additional information regarding the PROTEGE trial is available online at http://www.protegediabetes.org.

About Lilly

Lilly, a leading innovation-driven corporation, is developing a growing portfolio of first-in-class and best
'/>"/>

SOURCE Eli Lilly and Company
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine news :

1. Animal insulin product to be discontinued by drug major Eli Lilly
2. Did Eli Lilly Turn Wily With Regard to Their Best-selling Schizophrenia Drug?
3. Eli Lilly Releases Digital Insulin Pen
4. OHSU Researchers Announce New Discovery
5. PM announces a new health care order for India
6. Partnership Between Diabetes India And Elsevier Announced
7. US Politicians Urge Movie Moghuls To Add Anti-Smoking Announcements
8. Ramdoss Announces Introduction of RCH-II
9. Britain Announces Third Transfusion Related Mad Cow Case
10. Gates Foundation Announces $287 Million In Grants Towards AIDS Vaccine
11. Tibet Announces the Dalai Lama’s Tour of South Americ
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Steven Reinberg HealthDay ... A potential vaccine to protect children from the worldwide scourge ... Asian children. While the vaccine only prevented dengue fever ... full series of three shots, it protected more than 88 ... dengue fever can lead to hospitalization, and sometimes death. ...
(Date:7/11/2014)... 11, 2014 Ticket Down is ... the Sleep Train Amphitheatre in Wheatland, CA. In ... compare to what the Sleep Train Amphitheatre can do for ... special attractions over the course of its existence and can ... Train Amphitheatre in Wheatland (Sacramento metro area) will host the ...
(Date:7/11/2014)... 2014 Europe is one of the ... cultivated-and hence, irrigated land area. The agricultural sector is ... for around 30.0% of the total water use. The ... the southern region, but far from negligible in most ... for over 60.0% of the water use in most ...
(Date:7/11/2014)... years scientists have been trying to unravel mechanisms that ... cells that generate all blood cells including our immune ... difficult because they can only be found in the ... in a culture dish. Now a group of scientists ... Waskow (Technische Universitt Dresden) was able to generate a ...
(Date:7/11/2014)... Mexico (PRWEB) July 11, 2014 Experience ... the Mayan Heritage Experience Package at the luxury all-inclusive ... the package include a guided on-site ecological family tour ... well as The Coba Mayan Encounter Tour at the ... Nohoch Muul, the tallest pyramid in the Yucatan and ...
Breaking Medicine News(10 mins):Health News:Dengue Fever Vaccine Shows Some Promise in Trial 2Health News:Dengue Fever Vaccine Shows Some Promise in Trial 3Health News:Luke Bryan Tickets Sleep Train Amphitheatre in Wheatland, CA (Sacramento): Ticket Down has Slashed Ticket Prices on Luke Bryan in Wheatland at Sleep Train 2Health News:Luke Bryan Tickets Sleep Train Amphitheatre in Wheatland, CA (Sacramento): Ticket Down has Slashed Ticket Prices on Luke Bryan in Wheatland at Sleep Train 3Health News:Europe Micro Irrigation System Market Driven by Growing Environmental Concerns and Decreasing Water Availability - New Report by MicroMarket Monitor 2Health News:Europe Micro Irrigation System Market Driven by Growing Environmental Concerns and Decreasing Water Availability - New Report by MicroMarket Monitor 3Health News:Opening-up the stem cell niche 2Health News:Explore the Aura and Mystery of the Yucatan’s Mayan Culture with New Hotel Package at AAA Five Diamond Grand Velas Riviera Maya 2Health News:Explore the Aura and Mystery of the Yucatan’s Mayan Culture with New Hotel Package at AAA Five Diamond Grand Velas Riviera Maya 3
... (HealthDay News) -- Inadequate sleep and the absence of a ... of primary school children, research shows. When 6-year-old ... hours each night, their academic skills suffer along with their ... sleep less than is recommended for their intellectual development, which ...
... , FRIDAY, Sept. 16 (HealthDay News) -- People ... clotting and inflammation have a lower five-year survival rate ... findings should be used to better treat and ensure ... said the research team from Duke University Medical Center ...
... , FRIDAY, Sept. 16 (HealthDay News) -- Fall-prone older ... because they don,t slow their walking speed when their vision ... Fiona Newell of Trinity College in Dublin and colleagues, looked ... in the past year, six older adults who had not ...
... Sept. 16 (HealthDay News) -- People with dementia appear to ... nursing homes because they offer a domestic environment where patients ... And small group homes offer the added benefit of allowing ... pointed out in the study published in the September issue ...
... News) -- When people are hungry, they are more likely ... the reason why: serotonin levels -- a hormone that helps ... haven,t eaten, according to a new study. Rising ... allow people to control their anger, researchers from the University ...
... Scientists (AAPS) WHAT: , Scientists from around the ... discoveries in order to improve health through advances in pharmaceutical ... In recognition of AAPS,s 25th anniversary this year,s meeting, "The ... including more than 60 symposia and roundtables. WHEN: ...
Cached Medicine News:Health News:Lack of Sleep Hurts Kids' Academic Performance: Study 2Health News:Gene Variant May Raise Death Risk After Heart Bypass 2Health News:Dementia Patients Seem to Benefit From Small Group Homes 2Health News:Research Reveals Why Hungry People Get Cranky 2
(Date:7/11/2014)... 2014 According to a new ... Market (Endoscopes, Endoscopic Operative Devices, and Visualization Systems) - ... 2013-2019" the global endoscopy devices market was valued at ... grow at a CAGR of 6.8% from 2013 to ... billion in 2019. Browse the full Endoscopy ...
(Date:7/10/2014)... India , July 11, 2014  Major ... treatment of cancer are being highlighted in a ... Mumbai from 10-12 July, 2014.  Renowned national ... to share best practices and exchange knowledge on ... precise, accurate and efficient. The ...
(Date:7/10/2014)...  RESMED INC. (NYSE: RMD ) today announced ... ended June 30, 2014 results on Thursday, July 31, 2014, ... release with ResMed,s results will be issued after 1:00 p.m. ... to discuss operating results and future outlook. The ... Pacific Time and the live webcast of the call can ...
Breaking Medicine Technology:Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6Improving quality and access to advanced cancer care in India and South Asia 2Improving quality and access to advanced cancer care in India and South Asia 3Improving quality and access to advanced cancer care in India and South Asia 4Improving quality and access to advanced cancer care in India and South Asia 5ResMed To Announce Fourth Quarter And Fiscal Year-End 2014 Results 2
... Soligenix, Inc. (OTC Bulletin Board: SNGX ) ... today that it has appointed Kevin Horgan, MD, as ... Horgan is a board-certified gastroenterologist with a research background ... patients with inflammatory bowel disease, including graft-versus-host disease (GVHD). ...
... JOLLA, Calif., Feb. 1, 2011 Transdel Pharmaceuticals, ... a specialty pharmaceutical company focused on developing topically ... announced that the Company has been exploring strategic alternatives ... American MedTech Advisors and ESC Advisors, a division ...
Cached Medicine Technology:Soligenix Appoints Kevin Horgan, MD, as Chief Medical Officer 2Soligenix Appoints Kevin Horgan, MD, as Chief Medical Officer 3Soligenix Appoints Kevin Horgan, MD, as Chief Medical Officer 4Transdel Pharmaceuticals Announces Exploration of Strategic Alternatives 2Transdel Pharmaceuticals Announces Exploration of Strategic Alternatives 3
... you sleep on your dry ... morning awake with your eyes ... take on the day. Ideal ... protection, this preservative-free lubricant eye ...
... New REFRESH LIQUIGEL® Lubricant Eye Drops ... with the convenience of a liquid ... protection. Its extra-strength CMC formula provides ... comfort. And with the PURITE® preservative, ...
... ophthalmic solution is an anti-infective ... doctor may instruct you to ... eye infection caused by bacteria. ... are the 2 types of ...
ALPHAGAN® (brimonidine tartrate ophthalmic solution) 0.2% is indicated for lowering IOP in patients with open-angle galucoma or ocular hypertension....
Medicine Products: