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Lilly and MacroGenics Announce Licensing and Collaboration Agreement
Date:10/18/2007

ations for teplizumab or other next generation anti-CD3 molecules developed with MacroGenics. If Lilly pursues each one of those indications and they all ultimately gain approval, additional milestone payments to MacroGenics could exceed $600 million. Other terms of the deal were not disclosed.

The transaction is expected to become effective in the fourth quarter of 2007, contingent upon clearance under the Hart-Scott-Rodino Anti-Trust Improvements Act, if required. At closing, Lilly would expect a charge to earnings for acquired in-process research and development. The amount of the charge has not yet been determined, but is estimated to be $0.03 per share. The impact to Lilly's fourth quarter and full-year 2007 earnings per share guidance is included in the 2007 Financial Guidance section of Lilly's third quarter financial results press release that was issued today.

"This agreement will expand Lilly's pipeline of late stage molecules and will strengthen one of our core therapeutic areas," said David Moller, M.D., Lilly, vice president of endocrine and cardiovascular research and clinical investigation. "We remain committed to maintaining our leadership role in diabetes care, including an expanded presence in the area of type 1 diabetes. We will continue to seek out innovative molecules to add to our diabetes portfolio in order to best respond to the growing health crisis posed by diabetes worldwide."

"Teplizumab is a significant addition to our growing portfolio of biotechnology-derived medicines, which are a key strategy for Lilly," said Thomas Bumol, Ph.D., Lilly, vice president, biotechnology discovery research, and president, Applied Molecular Evolution. "Immune tolerance represents a novel therapeutic approach to the treatment of autoimmune disease, and we are excited to be partnering with MacroGenics to clinically evaluate this mechanism in type 1 diabetes."

"We are delighted to enter into this deal with Lilly, an established leader
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SOURCE Eli Lilly and Company
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