Navigation Links
Light powered platinum more targeted and 80 times more powerful than similar cancer treatments
Date:12/21/2007

Researchers from the Universities of Warwick, Edinburgh, Dundee and the Czech Republics Institute of Biophysics have discovered a new light-activated platinum-based compound that is up to 80 times more powerful than other platinum-based anti-cancer drugs and which can use light activation to kill cancer cells in much more targeted way than similar treatments.

The platinum-based compound known as trans, trans, trans- [Pt(N3)2(OH)2(NH3)(py)], or a light activated PtIV complex, is highly stable and non-toxic if left in the dark but if light falls upon it becomes much less stable and highly toxic to cancer cells. In fact it is between 13 and 80 times more toxic (depending on how and on which cells it is used) to cancer cells than the current platinum based anti-cancer drug Cisplatin. Moreover it kills the cells by a different mechanism of action, so it can also kill cisplatin-resistant cells.

Professor Peter Sadler, Chairman of the Chemistry Department of the University of Warwick, who led the research project said:

Light activation provides its massive toxic power and also allows treatment to be targeted much more accurately against cancer cells.

The compound could be used in particular to treat surface cancers. Patients could be treated in a darkened environment with light directed specifically at cancer cells containing the compound activating the compounds toxicity and killing those cells. Normal cells exposed to the compound would be protected by keeping the patient in darkness until the compound has passed through and out of the patient.

The new light activated PtIV complex is also more efficient in its toxic action on cancer cells in that, unlike other compounds currently used in photodynamic therapy, it does not require the presence of significant amounts of oxygen within a cancer cell to become toxic. Cancer cells tend to have less oxygen present than normal cells.

Although this work is in its early stages, the researches are hopeful that, in a few years time, the new platinum compound could be used in a new type of photoactivated chemotherapy for cancer.


'/>"/>

Contact: Peter Dunn
p.j.dunn@warwick.ac.uk
44-077-676-55860
University of Warwick
Source:Eurekalert

Related medicine news :

1. Stanford study highlights cost-effective method of lowering heart disease risks
2. Study shines more light on benefit of vitamin D in fighting cancer
3. Bacteria See the Light
4. Quantum light beams good for fast technology
5. Free will takes flight: how our brains respond to an approaching menace
6. New MRI finding sheds light on multiple sclerosis disease progressio
7. RA Drugs Linked to Slight Skin Cancer Risk
8. QUANTEL Intends to Strengthen its Dermatology/ Aesthetics Division With the Acquisition of WaveLight Aesthetic GmbH
9. REACH Registry Highlights That Patients With Peripheral Arterial Disease (PAD) Suffer High Rates of Heart Attack, Stroke, Hospitalization, and Death
10. Cardiovascular Technologies to be Highlighted at 5th Annual Cleveland Clinic Medical Innovation Summit, Oct. 1-3
11. First Circuit Court of Appeals Rules Against Philip Morris in Lights Class Action
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... ... May 31, 2016 , ... Like jewels in a crown, the multiple ... London is home to Ontario’s leading day spa and one of Canada’s few accredited ... with a unique concept to combine spa services with hair and beauty services ...
(Date:5/31/2016)... ... May 31, 2016 , ... Spectrum Aquatics has launched a brand new ADA ... and built with the user in mind. , “Over the last two years our ... an ADA 400 lbs lift is a necessary requirement for certain facilities with specific ...
(Date:5/31/2016)... (PRWEB) , ... May 31, 2016 , ... TeaZa® ... innovative herbal energy pouches, on World No Tobacco Day . The new ... retail locations later on this summer. , The new flavor is best described ...
(Date:5/31/2016)... ... 2016 , ... Advertising Age has recognized SourceLink, ... the tenth consecutive year as a Top 20 Marketing Services Agency. Final results ... eighteenth in the “U.S. CRM/Direct Marketing Agency” category. , Recent investments made ...
(Date:5/30/2016)... (PRWEB) , ... May 30, 2016 , ... As the ... for their children and their efforts to keep their households lice free. , ... Hawaii are enacting new policies that keep kids in the classroom despite the fact ...
Breaking Medicine News(10 mins):
(Date:5/30/2016)... , May 30, 2016 ... Analytical Testing Services Market by Type (Stability, Raw ... by End User (Pharmaceutical Companies, Medical Device Companies) ... The market witnessed healthy growth during the last ... CAGR of 11.3% between 2016 and 2021 to ...
(Date:5/30/2016)... -- - DCGI grants limited approval to market Stempeucel® ... - Stempeucel® becomes 5th off-the-shelf Stem cell product to be ... - Buerger,s Disease (also known as Thromboangiitis Obliterans) is a major ... - Prevalence of Buerger,s Disease is estimated to be ... persons in the European Community & USA ...
(Date:5/27/2016)...  A new study highlights the necessity of health literacy within the technology advancement ... College of Radiology , a majority of oncology patients undergo imaging screenings without understanding ... ... ... Medical Diagnostic Imaging Ampronix ...
Breaking Medicine Technology: