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Light Sciences Oncology Announces Results of Study on Immunotherapeutic Mechanism of Aptocine(TM), a Novel Light-Activated Drug Therapy for Cancer
Date:5/18/2009

Preclinical Study is Subject of Upcoming ASCO Presentation

BELLEVUE, Wash., May 18 /PRNewswire/ -- Light Sciences Oncology, Inc. (LSO) today announced that a new preclinical study has yielded evidence that the company's novel light-activated drug Aptocine(TM) (formerly Litx(TM)) may enhance anti-tumor immunity and prevent metastases. Results of the study will be presented in a poster session at the annual American Society of Clinical Oncology (ASCO) meeting in Orlando, Florida, on May 30, 8:00 AM - 12:00 PM. The study was conducted by Dr. Sandra Gollnick at the Roswell Park Cancer Institute in Buffalo, New York.

"With mounting evidence that Aptocine may be an active immunotherapy in addition to its demonstrated ability to ablate tumors, this drug may offer greater benefit to cancer patients than initially contemplated. Dr. Gollnick's thorough and exhaustive study defines an immune effect in cancer which is unprecedented," said LSO's President and CEO Llew Keltner, M.D., Ph.D.

In the preclinical study, Aptocine was used to treat primary tumors and examine prevention of metastases in the 4T1 tumor model, an aggressive, spontaneously metastasizing murine mammary tumor model that mirrors human breast cancer. When grown in the mammary fat pad of BALB/c mice, untreated 4T1 tumors rapidly metastasize to the lung, liver, lymph nodes, and brain. Primary 4T1 tumors grown in mice were treated and animal survival was followed. To determine whether the therapy could enhance anti-tumor immunity and reduce metastases, the lymph node (LN) cells from treated and control mice were transferred to naive recipient mice. Recipients were challenged with a tumorigenic dose of 4T1 cells 3 days after adoptive transfer and primary and secondary tumor growth in the recipients was examined.

Key outcomes of the study include:

  • Aptocine treatment significantly prolonged survival in treated ani
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SOURCE Light Sciences Oncology, Inc.
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