Navigation Links
Light-Activated Therapy Seems to Rejuvenate Aging Skin
Date:10/20/2008

Photosensitive med plus pulsed laser boosted collagen, study says

MONDAY, Oct. 20 (HealthDay News) -- Photodynamic therapy appears to cause molecular-level changes in aging skin that increase collagen production and improve skin appearance, a U.S. study finds.

In photodynamic therapy, a light-activated medication is exposed to a light source. Photodynamic therapy for aesthetic treatments typically involves application of a topical medication, such as 5-aminolevulinic acid (5-ALA).

In this study, Dr. Jeffrey S. Orringer and colleagues at the University of Michigan Medical School in Ann Arbor, used photodynamic therapy to treat 25 people, aged 54 to 83, with sun-damaged skin on their forearms.

Prior to treatment, the patients' degree of skin damage was rated, and tissue samples were taken from their forearms. A solution containing 5-ALA was applied to the damaged skin and left on for three hours. The skin was then cleaned and treated with a pulsed-dye laser. The patients were re-examined four to five times over the following six months.

Tissue samples showed that treatment resulted in a fivefold increase in levels of a protein called Ki67, believed to play an important role in the growth and development of new skin cells. In addition, there was a 1.4-fold increase in the thickness of the skin's outer layer (epidermis) and higher levels of enzymes and other compounds associated with the production of collagen, the main structural protein in skin.

The findings were published in the October issue of the Archives of Dermatology.

"Photodynamic therapy with the specific treatment regimen employed produces statistically significant quantitative cutaneous molecular changes [e.g., production of types I and III collagen] that are associated with improved appearance of the skin," the researchers wrote.

The findings suggest that use of a photosensitive compound such as 5-ALA in combination with pulsed-dye laser therapy prompts more beneficial changes in skin than laser therapy alone.

"Although our molecular measurements cannot yet precisely predict clinical outcomes for a single given patient, taken together they are very much in keeping with the bulk of the clinical literature and thus lend substantial support to the conclusions reached by other researchers who have published purely clinically oriented work in this field," the study authors concluded.

"We believe that the quantitative amount of dermal repair and regeneration induced by a specific therapeutic intervention very likely underlies the degree of clinical rejuvenation produced." they wrote. "Thus, it is our hope that, with further development, our working molecular model may one day be used to predict the clinical value of new technologies in aesthetic dermatology."

More information

The National Institute on Aging has more about skin care and aging.



-- Robert Preidt



SOURCE: JAMA/Archives journals, news release, Oct. 20, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New Method of Therapy Takes Patients Out of the Clinic and Into the Park
2. Grupo IMO Hosts Symposium on Use of TomoTherapy for Stereotactic Radiosurgery and Stereotactic Body Radiation Procedures : Experts Detail HiArt Platform Advantages for Treatment of Brain, Lung, Pancreatic and Metastatic Cancers
3. Clinicians in Netherlands Treat Lung Cancer Patients Using New RapidArc Radiotherapy Technology from Varian Medical Systems
4. NeoVista Presents Anatomic Outcomes of Novel Wet AMD Therapy at 2008 American Society of Retina Specialists Meeting
5. Schwabe, World Leader in Herbal Manufacturing Will Acquire Enzymatic Therapy Through Natures Way Holding, Inc.
6. HelpPRO and Give an Hour Join to Help Military Families Get Free Therapy Services
7. FDA Clears NeuroStar(R) TMS Therapy for the Treatment of Depression
8. Will patients stick to physical therapy? Questionnaire can help doctors predict
9. Occupational Therapy Plus Exercise Benefits Osteoarthritis
10. Cognitive Behavioral Therapy Best for Traumatized Youths
11. OHSU Cancer Institute researcher: radiation, immunotherapy gives greater effectiveness
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Light-Activated Therapy Seems to Rejuvenate Aging Skin 
(Date:2/24/2017)... ... February 24, 2017 , ... An in-depth computational analysis of ... of Pittsburgh points to eight genes that may explain why susceptibility to one of ... results of a study published today in the journal npj Schizophrenia. , “There ...
(Date:2/24/2017)... ... February 24, 2017 , ... Healthcare Associates of ... Center at Craig Ranch building at 8080 State Highway 121, Suite 210, McKinney, Texas ... easy access to Highway 121. , As the practice has grown, the need for ...
(Date:2/24/2017)... ... February 24, 2017 , ... The International Association of Eating Disorders Professionals ... What You See” body image mannequin art competition. Selected from 15 submissions from around ... winner revealed at the 31st annual iaedp Symposium, March 22 – 26 in Las ...
(Date:2/24/2017)... ... February 24, 2017 , ... ... again hosted their Military Wedding Giveaway, with the winning couple announced on Feb. ... with services generously donated from local vendors: A Matter of Taste, Ryan Rousseau ...
(Date:2/23/2017)... , ... February 23, 2017 , ... ... with a clinician-based audience, will be participating in Rare Disease Day events, hosted ... D.C. In addition, Rare Disease Report, a website, weekly e-newsletter and quarterly publication, ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... 23, 2017 Research and Markets has announced ... and Strategies - 2016" report to their offering. ... The latest research Autism ... pricing data and benchmarks in the global Autism Spectrum Disorder market. ... What are the key drugs marketed for Autism Spectrum Disorder ...
(Date:2/23/2017)... Limited, ( ASX: ITD ), an innovative diversified healthcare company, is ... December 2016 compared with the previous corresponding period. A full "Results ... . Highlights Profit after ... Earnings per share of 2.2 cents (Dec 2015: 1.2 cents; up ... 11%) Profit before tax of $2.12m (Dec 2015: ...
(Date:2/23/2017)... -- Research and Markets has announced the addition of ... report to their offering. ... The latest research Oesophageal Cancer Drugs Price Analysis ... the global Oesophageal Cancer market. The research answers the ... drugs marketed for Oesophageal Cancer and their clinical attributes? How are ...
Breaking Medicine Technology: