Navigation Links
Light-Activated Therapy Seems to Rejuvenate Aging Skin
Date:10/20/2008

Photosensitive med plus pulsed laser boosted collagen, study says

MONDAY, Oct. 20 (HealthDay News) -- Photodynamic therapy appears to cause molecular-level changes in aging skin that increase collagen production and improve skin appearance, a U.S. study finds.

In photodynamic therapy, a light-activated medication is exposed to a light source. Photodynamic therapy for aesthetic treatments typically involves application of a topical medication, such as 5-aminolevulinic acid (5-ALA).

In this study, Dr. Jeffrey S. Orringer and colleagues at the University of Michigan Medical School in Ann Arbor, used photodynamic therapy to treat 25 people, aged 54 to 83, with sun-damaged skin on their forearms.

Prior to treatment, the patients' degree of skin damage was rated, and tissue samples were taken from their forearms. A solution containing 5-ALA was applied to the damaged skin and left on for three hours. The skin was then cleaned and treated with a pulsed-dye laser. The patients were re-examined four to five times over the following six months.

Tissue samples showed that treatment resulted in a fivefold increase in levels of a protein called Ki67, believed to play an important role in the growth and development of new skin cells. In addition, there was a 1.4-fold increase in the thickness of the skin's outer layer (epidermis) and higher levels of enzymes and other compounds associated with the production of collagen, the main structural protein in skin.

The findings were published in the October issue of the Archives of Dermatology.

"Photodynamic therapy with the specific treatment regimen employed produces statistically significant quantitative cutaneous molecular changes [e.g., production of types I and III collagen] that are associated with improved appearance of the skin," the researchers wrote.

The findings suggest that use of a photosensitive compound such as 5-ALA in combination with pulsed-dye laser therapy prompts more beneficial changes in skin than laser therapy alone.

"Although our molecular measurements cannot yet precisely predict clinical outcomes for a single given patient, taken together they are very much in keeping with the bulk of the clinical literature and thus lend substantial support to the conclusions reached by other researchers who have published purely clinically oriented work in this field," the study authors concluded.

"We believe that the quantitative amount of dermal repair and regeneration induced by a specific therapeutic intervention very likely underlies the degree of clinical rejuvenation produced." they wrote. "Thus, it is our hope that, with further development, our working molecular model may one day be used to predict the clinical value of new technologies in aesthetic dermatology."

More information

The National Institute on Aging has more about skin care and aging.



-- Robert Preidt



SOURCE: JAMA/Archives journals, news release, Oct. 20, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New Method of Therapy Takes Patients Out of the Clinic and Into the Park
2. Grupo IMO Hosts Symposium on Use of TomoTherapy for Stereotactic Radiosurgery and Stereotactic Body Radiation Procedures : Experts Detail HiArt Platform Advantages for Treatment of Brain, Lung, Pancreatic and Metastatic Cancers
3. Clinicians in Netherlands Treat Lung Cancer Patients Using New RapidArc Radiotherapy Technology from Varian Medical Systems
4. NeoVista Presents Anatomic Outcomes of Novel Wet AMD Therapy at 2008 American Society of Retina Specialists Meeting
5. Schwabe, World Leader in Herbal Manufacturing Will Acquire Enzymatic Therapy Through Natures Way Holding, Inc.
6. HelpPRO and Give an Hour Join to Help Military Families Get Free Therapy Services
7. FDA Clears NeuroStar(R) TMS Therapy for the Treatment of Depression
8. Will patients stick to physical therapy? Questionnaire can help doctors predict
9. Occupational Therapy Plus Exercise Benefits Osteoarthritis
10. Cognitive Behavioral Therapy Best for Traumatized Youths
11. OHSU Cancer Institute researcher: radiation, immunotherapy gives greater effectiveness
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Light-Activated Therapy Seems to Rejuvenate Aging Skin 
(Date:10/13/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has released ... understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a picture ... Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that is ...
(Date:10/13/2017)... ... ... Journey: From the Mountains to the Mission Field”: the story of a missionary couple ... From the Mountains to the Mission Field” is the creation of published author, Carole ... and currently teaches a class of ladies at her church, which she has taught ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... are now treating sleep apnea using cutting-edge Oventus O2Vent technology. As ... serious sleep disorder characterized by frequent cessation in breathing. Oral appliances can offer ...
(Date:10/12/2017)... ... ... IsoComforter, Inc. ( https://isocomforter.com ), one of the Nation’s premier ... of the shoulder pad. The shoulder pad provides optimal support and full contact ... using cold therapy. By utilizing ice and water that is circulated from an insulated ...
(Date:10/12/2017)... Maryland (PRWEB) , ... October 12, 2017 , ... ... magnetic drug delivery system that we intend to develop to enable prevention of ... can lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), a leading ... announced that its MyDario product is expected to appear on The Dr. ... The Dr. Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. Oz Show ... The segment ...
(Date:9/22/2017)... , Sept. 22, 2017 AVACEN Medical ... device is now successfully helping those with the widespread ... Fibromyalgia diagnosed Amanda in Essex, England ... and washing my hair, experiencing no sleep at all, ... painful spasm… I cannot recommend [the AVACEN 100] enough, ...
(Date:9/13/2017)... has been named the official orthopedic and sports medicine ... 2018 College Football Playoff (CFP) National Championship to be played ... Atlanta, Georgia . OrthoAtlanta is proud to be ... many activities leading up to, and including the national championship ... OrthoAtlanta serves ...
Breaking Medicine Technology: