Navigation Links
Light-Activated Therapy Seems to Rejuvenate Aging Skin
Date:10/20/2008

Photosensitive med plus pulsed laser boosted collagen, study says

MONDAY, Oct. 20 (HealthDay News) -- Photodynamic therapy appears to cause molecular-level changes in aging skin that increase collagen production and improve skin appearance, a U.S. study finds.

In photodynamic therapy, a light-activated medication is exposed to a light source. Photodynamic therapy for aesthetic treatments typically involves application of a topical medication, such as 5-aminolevulinic acid (5-ALA).

In this study, Dr. Jeffrey S. Orringer and colleagues at the University of Michigan Medical School in Ann Arbor, used photodynamic therapy to treat 25 people, aged 54 to 83, with sun-damaged skin on their forearms.

Prior to treatment, the patients' degree of skin damage was rated, and tissue samples were taken from their forearms. A solution containing 5-ALA was applied to the damaged skin and left on for three hours. The skin was then cleaned and treated with a pulsed-dye laser. The patients were re-examined four to five times over the following six months.

Tissue samples showed that treatment resulted in a fivefold increase in levels of a protein called Ki67, believed to play an important role in the growth and development of new skin cells. In addition, there was a 1.4-fold increase in the thickness of the skin's outer layer (epidermis) and higher levels of enzymes and other compounds associated with the production of collagen, the main structural protein in skin.

The findings were published in the October issue of the Archives of Dermatology.

"Photodynamic therapy with the specific treatment regimen employed produces statistically significant quantitative cutaneous molecular changes [e.g., production of types I and III collagen] that are associated with improved appearance of the skin," the researchers wrote.

The findings suggest that use of a photosensitive compound such as 5-ALA in combination with pulsed-dye laser therapy prompts more beneficial changes in skin than laser therapy alone.

"Although our molecular measurements cannot yet precisely predict clinical outcomes for a single given patient, taken together they are very much in keeping with the bulk of the clinical literature and thus lend substantial support to the conclusions reached by other researchers who have published purely clinically oriented work in this field," the study authors concluded.

"We believe that the quantitative amount of dermal repair and regeneration induced by a specific therapeutic intervention very likely underlies the degree of clinical rejuvenation produced." they wrote. "Thus, it is our hope that, with further development, our working molecular model may one day be used to predict the clinical value of new technologies in aesthetic dermatology."

More information

The National Institute on Aging has more about skin care and aging.



-- Robert Preidt



SOURCE: JAMA/Archives journals, news release, Oct. 20, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New Method of Therapy Takes Patients Out of the Clinic and Into the Park
2. Grupo IMO Hosts Symposium on Use of TomoTherapy for Stereotactic Radiosurgery and Stereotactic Body Radiation Procedures : Experts Detail HiArt Platform Advantages for Treatment of Brain, Lung, Pancreatic and Metastatic Cancers
3. Clinicians in Netherlands Treat Lung Cancer Patients Using New RapidArc Radiotherapy Technology from Varian Medical Systems
4. NeoVista Presents Anatomic Outcomes of Novel Wet AMD Therapy at 2008 American Society of Retina Specialists Meeting
5. Schwabe, World Leader in Herbal Manufacturing Will Acquire Enzymatic Therapy Through Natures Way Holding, Inc.
6. HelpPRO and Give an Hour Join to Help Military Families Get Free Therapy Services
7. FDA Clears NeuroStar(R) TMS Therapy for the Treatment of Depression
8. Will patients stick to physical therapy? Questionnaire can help doctors predict
9. Occupational Therapy Plus Exercise Benefits Osteoarthritis
10. Cognitive Behavioral Therapy Best for Traumatized Youths
11. OHSU Cancer Institute researcher: radiation, immunotherapy gives greater effectiveness
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Light-Activated Therapy Seems to Rejuvenate Aging Skin 
(Date:10/13/2017)... AR (PRWEB) , ... October 13, 2017 , ... ... with locations throughout Arkansas that offers insurance and financial preparation services, is providing ... the Rock City Rescue organization. , Rock City Rescue is a locally recognized ...
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading Health and Nutrition ... the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly growing CBD market ... can be easily incorporated into liquid products, while reducing costs to end users. , ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) ... a collection of specialty vendors and unique items from across the nation, this holiday-themed ... and wellness services offered by the VNA. The boutique will be open Saturday, ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, ... Development, has been awarded a contract by the Center for Medicare and Medicaid ... to accelerate the enterprise use of Agile methodologies in a consistent and high ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Planet Fitness, one ... U.S., announced today its plans to open a flagship location in Covington, LA at ... former Rooms To Go store next to Office Depot in the Holiday Square shopping ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)...  Commended for their devotion to personalized service, SMP Pharmacy ... one in the South Florida Business Journal,s 50 Fastest-Growing Companies, ... list, the national specialty pharmacy has found its niche.  To ... soon be honored by SFBJ as the 2017 Power Leader ... to receive his award in October, Bardisa said of the ...
(Date:9/23/2017)... Janssen Biotech, Inc. (Janssen) announced today that ... U.S. Food and Drug Administration (FDA) for the Biologics ... treatment of moderately to severely active rheumatoid arthritis (RA). ... needed to further evaluate the safety of sirukumab in ... "We are disappointed ...
(Date:9/19/2017)... 19, 2017   ZirMed Inc ., a recognized leader ... that it has been ranked #1 by its users for ... Rankings 2017 User Survey. ZirMed was recognized as the top-ranked ... and medical centers over 200 beds and holds one of ... user survey history. ...
Breaking Medicine Technology: