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Lifestyle and cancer prevention: Making choices that change cancer risk
Date:12/7/2007

not always a fatal cancer, it does account for about 2,000 cancer deaths a year.

For years, the projects lead researcher Tatiana Oberyszyn, Ph.D., assistant professor at Ohio States Department of Pathology has studied gender differences in non-melanoma skin cancer. She and her laboratory had initially discovered through controlled experiments that gender and its associated variables accounted for the difference between male and female rates of developing squamous cell carcinomas.

In this study, the researchers discovered that, to their surprise, male mice had less inflammation following exposure to UV light than did female mice, but they had increased oxidative DNA damage possibly due to insufficient levels of proteins that repair DNA damage.

When equally exposed to sunlight, female skin turns pink and swells up − two classic signs of a sunburn, Tober said. Male skin doesn't have as robust of a sunburn response to UV exposure but the genetic damage that male skin incurs is actually greater than female mice.

Our data tells us that female skin has more antioxidants, compounds that scavenge DNA damaging chemicals, and potentially more mechanisms to repair DNA damage than male skin, she said. These gender differences suggest that female skin has a higher capacity for repairing sunlight induced DNA damage than does male skin. Without complete repair of this genetic damage, male skin is more prone to skin cancer than is female skin.

These findings suggest that gender may need to be considered when it comes to controlling cancer, the researchers say. Until those strategies are determined and whether you are male or female, it is best to take caution when it comes to sunlight exposure, Tober said.


Nicotine metabolism among African American and white smokers: Group and intraindividual differences in glucuronidation. Abstract no. B122

It has long been known that African-American smokers hav
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Contact: Greg Lester
greg.lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

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