Navigation Links
Lifestyle Changes Affect Cancer Genes
Date:6/17/2008

Healthy diet, exercise and stress-reduction spur healthy alterations in DNA, study finds,,,,

TUESDAY, June 17 (HealthDay News) -- Genes may not fully control your destiny when it comes to cancer risk, according to a new study of men with prostate cancer.

New research suggests that stringent dietary changes, getting more exercise and practicing stress reduction can change the expression of hundreds of genes. Some of the changes positively affect genes that help fight cancer, while others help turn off genes that promote cancer development, according to the study, which is in this week's issue of the Proceedings of the National Academy of Sciences.

"These findings are very exciting. They counter the genetic nihilism I hear so often. People say, 'It's all in my genes, there's nothing I can do,' but actually you can do quite a lot," said the study's lead author, Dr. Dean Ornish, president of the Preventive Medicine Research Institute and a clinical professor of medicine at the University of California, San Francisco.

Previous epidemiological studies have found that the incidence of prostate cancer is significantly lower in areas of the world where people eat a more plant-based, low-fat diet instead of the higher-fat, higher-protein diet often consumed in the United States. Because of these findings, Ornish and his colleagues initially set out to see if altering diet and lifestyle could decrease the amount of prostate-specific antigen (PSA) in men who'd been diagnosed with early prostate cancer. PSA is a blood marker for prostate growth.

In September 2005, they reported that after intensive lifestyle changes -- consuming a vegan diet with about 10 percent of calories from fat, walking 30 minutes six times a week, and practicing stress management one hour daily -- men with early prostate cancer lowered their PSA scores by 4 percent, while men in the control group saw their PSA score rise by 6 percent.

But, the researchers didn't know what the mechanism behind the change was, according to Ornish. The current study was designed to elucidate the reasons behind the improvement.

Thirty men diagnosed with early prostate cancer were enrolled in the study. The men were predominantly white (84 percent), with an average age of 62.3 years, and an average PSA score of 4.8 nanograms per milliliter (ng/ml). Their Gleason scores -- another measure of the severity of the cancer -- were an average of six.

All of the men had already declined immediate surgery, hormonal therapy or radiation. Instead, they chose to have their tumors periodically monitored to ensure that they remained slow-growing.

The lifestyle interventions began with a 3-day residential retreat, followed by weekly telephone consultations and a one-hour group support session each week. The study participants were provided all of their food and were asked to follow a plant-based diet containing about 10 percent of calories from fat. They were also told to walk for 30 minutes a day, six days a week.

Additionally, the study volunteers practiced stress management for 60 minutes a day. Stress management techniques included yoga-based stretching, breathing exercises, meditation, imagery, and progressive relaxation. The study volunteers were also given additional soy, three grams of fish oil, 100 units of vitamin E, 200 milligrams of selenium and 2 grams of vitamin C daily.

The researchers compared genetic expression from baseline samples to those taken after three months of study intervention and found positive changes in more than 500 genes, according to Ornish.

"I thought younger people with milder disease would show the most improvement, but neither age nor disease severity made as much difference as adherence," said Ornish. That means that the more people are able to change, the better. And, these findings suggest that you're never too old to make changes that can positively affect your health.

"It's encouraging to see that by going on a very low-fat diet that you can change gene expression in the prostate itself, but just because changes can happen, you don't yet know if it would mean anything for cancer risk," said Dr. Simon J. Hall, director of the Deane Prostate Health and Research Center, and the chairman of urology at Mount Sinai School of Medicine in New York City.

Hall said he'd like to see them follow these men for a long time to see what these genetic changes eventually mean.

Ornish said this study's findings were "very unexpected, and we've raised more questions than we've answered."

In any case, Hall added, it's clear that if you can make lifestyle changes like those in the study, you can definitely improve your cardiovascular health.

More information

To learn more about how food and exercise can affect your cancer risk, visit the American Cancer Society.



SOURCES: Dean Ornish, M.D., president and founder, Preventive Medicine Research Institute, and clinical professor of medicine, University of California, San Francisco; Simon J. Hall, M.D., director, Deane Prostate Health and Research Center, and chairman of the department of urology, Mount Sinai School of Medicine, New York City; June 16-20, 2008 Proceedings of the National Academy of Sciences


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Mothers Know Best: NFL Moms Team With Eddie George to Showcase a Better Way to a Healthier Lifestyle
2. Eat Seafood, See Weight Loss: Recent Study Finds Another Reason to Eat Seafood for a Fit Lifestyle
3. Activate America(R) Brings Together YMCAs Nationwide to Promote Small Steps Toward a Healthier Lifestyle During America on the Move Week With the YMCA, September 22-29, 2007
4. YMCAs Activate America(R) Motivates More Than 1.3 Million People to Take 8 Billion Steps Toward a Healthier Lifestyle During America On the Move Week with the YMCA
5. Harvard Medical School: Healthy Lifestyle Will Boost Your Immune System Better Than a Handful of Supplements
6. Diet and lifestyle changes may help prevent infertility from ovulatory disorders
7. Diet, Lifestyle Changes Cut Some Infertility Risk
8. Elderly with high blood pressure less likely to get lifestyle modification advice from doctors
9. Demystifying Diabetes: The Complete Diabetes Lifestyle
10. Older Hypertension Patients Less Likely to Get Lifestyle Advice
11. it Girl Public Relations Adds O.N.I. New Organic Food Delivery Service to Its Lifestyle Division
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Lifestyle Changes Affect Cancer Genes
(Date:2/17/2017)... TN (PRWEB) , ... February 17, 2017 , ... ... mobility has not kept pace. Enovate Medical has introduced an innovative workstation designed ... years of supporting nurses, the Encore Mobile EHR Workstation offers a lightweight, highly ...
(Date:2/17/2017)... Rancho Palos Verdes, CA (PRWEB) , ... February ... ... well-being, and emotional flow is Dr. Carol Francis' goals for each ... Federation Retreat Conference, Dr. Carol Francis will demonstrate five different brainwave tools which ...
(Date:2/17/2017)... ... February 17, 2017 , ... MAP ... today that Karen Pilley has been promoted to Chief Executive Officer. , ... healthcare paradigm – a shift that demands the transition from pay-for-service to pay-for-performance ...
(Date:2/17/2017)... ... February 17, 2017 , ... Top neuroendocrine cancer doctors, nurses and specialists ... from February 21 - 23 in Beaver Creek, CO. It was announced today by ... second year in Beaver Creek, hosting over 60 faculty members and addressing unmet needs ...
(Date:2/16/2017)... (PRWEB) , ... February 17, 2017 , ... Teaching nursing ... (ACE) program, now in development. ACE.P (pediatrics) is being created with the support of ... Care of Vulnerable Populations , ACE.P will address what has been identified as a ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)...  Perrigo Company plc (NYSE, TASE: PRGO) today announced it ... Administration for hydrocodone bitartrate and homatropine methylbromide oral solution (syrup), ... bitartrate and homatropine methylbromide oral solution (syrup), 5 mg/1.5 mg ... cough in adults and children 6 years of age and ... were approximately $16 million.   ...
(Date:2/17/2017)... , Feb 17, 2017 Research and Markets has ... Report" report to their offering. ... The report provides separate comprehensive analytics for the US, ... , Asia-Pacific , Latin America , ... period 2015 through 2022. Also, a six-year historic analysis is provided for ...
(Date:2/17/2017)... 2017  In partnership with CitiHope , ... , The Jack Brewer Foundation (JBF Worldwide) ... dollars, worth of medicine to Innovating Health International ... a non-profit dedicated to treating chronic diseases and addressing women,s ... Haiti and providing these medicines ...
Breaking Medicine Technology: