Navigation Links
Life savers in the gut
Date:1/9/2008

Researchers from the European Molecular Biology Laboratory (EMBL) have discovered that proteins that regulate the body's iron household play a vital role in making sure enough nutrients and water are absorbed in the intestine. Mice lacking these proteins suffer from weight loss and dehydration, the scientists report in the current issue of Cell Metabolism.

Iron is a central component of red blood cells and has many other important functions throughout the body. Since too little or too much iron is dangerous for our health a range of regulatory proteins tightly controls iron metabolism. EMBL scientists now assessed the role of two of these proteins, iron regulatory proteins 1 and 2 (IRPs), for the first time in living mice and found that their effects are much broader than previously assumed.

We generated the first living organism lacking both IRPs in one of its organs,?says Bruno Galy, who carried out the research in the lab of Matthias Hentze at EMBL. This was extremely challenging, because if both proteins are switched off throughout the whole body, the mouse dies before birth. But if you switch off only one IRP, the one that is still intact substitutes and you can hardly see any effects.?

Surprisingly, the lack of IRPs in the intestine did not upset the mice's iron household in blood and tissues. Instead the mice suffered from other, unexpected problems: they weighed only half of their normal littermates, suffered from severe dehydration and died only 4 weeks after birth. The general nutrient and water absorption in the gut was impaired. A closer look at the intestinal tissues revealed that their structure and organisation were completely disturbed, which likely affects all absorption processes that happen in intestinal cells. The findings show that IRPs are essential for intestinal function and the survival of an organism, but the details of how they accomplish their effects is unclear.

Although the global iron household was unaffected b
'/>"/>

Contact: Anna-Lynn Wegener
anna.wegener@embl.de
49-622-138-78452
European Molecular Biology Laboratory
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Americas Top Hospitals Are Real Lifesavers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/1/2015)... (PRWEB) April 01, 2015 San Francisco ... the international children’s medical charity, Operation Smile, ... global partnership. , Campaign Details: RxOrganics is generously ... line to Operation Smile throughout 2015. RxOrganics has ... such sales so that every order placed online through ...
(Date:4/1/2015)... (PRWEB) April 01, 2015 Results are ... Challenge , which featured 11 new homes from across ... residences that best utilized innovative building techniques and new ... net-zero. Steven Winter Associates, Inc. (SWA) provided sustainability consulting ... this year’s challenge, including the first- and third-place winners. ...
(Date:4/1/2015)... Oak Brook, IL (PRWEB) April 01, 2015 ... unfortunately benefited greatly from climate change in recent years, ... will develop an allergic reaction if exposed to poison ... as outdoor enthusiasts and families prepare for summer adventures ... of an uncomfortable poison plant reaction is greater than ...
(Date:3/31/2015)... Riverdale, New York (PRWEB) April 01, 2015 ... retired Sisters of Charity to the Schervier Nursing Care ... the Convent of Mary the Queen in Yonkers which ... to Sister Jane Iannucelli, SC, president of the Sisters ... Sisters of Charity board of directors to place their ...
(Date:3/31/2015)... As the demand for optimized mobile content ... a mobile-friendly website online sometime during the month of ... continued commitment to bring the best and most accurate ... the same great fitness information at http://www.chunkfitness.com ... to read while browsing on a mobile device. , ...
Breaking Medicine News(10 mins):Health News:RxOrganics Forges Unique Partnership to Bring More Smiles to Underserved Global Heath Communities 2Health News:Steven Winter Associates’ Projects Receive Top Honors in CT Zero Energy Challenge 2Health News:Steven Winter Associates’ Projects Receive Top Honors in CT Zero Energy Challenge 3Health News:Steven Winter Associates’ Projects Receive Top Honors in CT Zero Energy Challenge 4Health News:New Ivarest Poison Ivy Itch Spray Provides All-Day Comfort 2Health News:Bon Secours New York Health System Welcomes Retired Sisters of Charity to the Family 2
... ... a symptom of cancer rather than a cause.,• Possible benefit of higher HDL and cancer ... ... Association for Cancer Research hosted a press briefing on this study on Tuesday, Nov. 3, ...
... half of those with lung disease symptoms remain undiagnosed, experts ... Americans are aware of chronic obstructive pulmonary disease (COPD), but ... be treated, according to national survey results released this week ... Month in November. , COPD affects 20 percent of U.S. ...
... , ... of the US Food and Drug Administration (FDA), will deliver the opening keynote address to ... (DIA) 46th Annual Meeting. , ... Horsham, PA (Vocus) November 4, 2009 -- Dr. Margaret Hamburg, Commissioner of the ...
... , ... BibsToGo.com launches a line of disposable, recyclable and customizable bibs to help keep both children ... Video Solutions of Rye, NY. , ... ,Dix Hills, NY (PRWEB) November 4, 2009 -- Andre Muller is a ...
... In order to help millions of Americans ... conditions, depression and obesity, the Neutraceutical Company, LLC ... the ability to address both issues safely and ... brand, has clinically established a remarkable success in ...
... Jude Children,s Research Hospital launched the sixth annual Thanks ... retail and corporate partners that ask consumers to "Give thanks ... those who are not." The announcement was made today by ... , For the first time, GRAMMY® Award-nominated singer and ...
Cached Medicine News:Health News:Cholesterol and Cancer: Answers and Some New Questions 2Health News:Cholesterol and Cancer: Answers and Some New Questions 3Health News:Cholesterol and Cancer: Answers and Some New Questions 4Health News:Cholesterol and Cancer: Answers and Some New Questions 5Health News:Americans Gaining Awareness of COPD: Survey 2Health News:FDA Commissioner Margaret Hamburg to Deliver Keynote Address at DIA 46th Annual Meeting, June 13-17, 2010 in Washington, DC , 2Health News:FDA Commissioner Margaret Hamburg to Deliver Keynote Address at DIA 46th Annual Meeting, June 13-17, 2010 in Washington, DC , 3Health News:BibsToGo.com Answers: How Can a Traditional Baby Product Help Corporate America Look Better? 2Health News:New Product Launch - SAFFRENE Delivers Impressive Mood Elevation and Weight-loss Benefits 2Health News:Stars of Film, Television, Sports and Music Join Marlo Thomas to Kick Off the 6th Annual Thanks and Giving(R) Campaign to Support St. Jude Children's Research Hospital(R) 2Health News:Stars of Film, Television, Sports and Music Join Marlo Thomas to Kick Off the 6th Annual Thanks and Giving(R) Campaign to Support St. Jude Children's Research Hospital(R) 3Health News:Stars of Film, Television, Sports and Music Join Marlo Thomas to Kick Off the 6th Annual Thanks and Giving(R) Campaign to Support St. Jude Children's Research Hospital(R) 4Health News:Stars of Film, Television, Sports and Music Join Marlo Thomas to Kick Off the 6th Annual Thanks and Giving(R) Campaign to Support St. Jude Children's Research Hospital(R) 5
(Date:3/31/2015)... 27, 2015 Research and Markets ( ... "Intraoperative Imaging Market by Type (Intraoperative CT, Intraoperative MRI, ... to their offering. The global intraoperative imaging ... 3.5% from 2014 to 2019 It holds ... number of forces that favor this market. The need ...
(Date:3/31/2015)... , March 31, 2015 ... "Life Science and Chemical Instrumentation Market (Chromatography, Electrophoresis, DNA ... Flow Cytometer, Incubator, Fume Hood, Centrifuge) - Global ... Life Science and Chemical Instrumentation Market is expected ... of 6.9% from 2014 to 2019. ...
(Date:3/31/2015)... March 31, 2015  SCILEX Pharmaceuticals, Inc., a company ... on the treatment of pain, today announced that ITOCHU ... ), a member of ITOCHU Corporation ( Tokyo ... leading sogo shosha (general trading companies) in ... SCILEX.  ICF has worked closely with SCILEX as an ...
Breaking Medicine Technology:Global Intraoperative Imaging (Intraoperative CT, Intraoperative MRI, Intraoperative Ultrasound) Market 2015-2019 2Life Science and Chemical Instrumentation Market Worth $48.84 Billion by 2019 2Life Science and Chemical Instrumentation Market Worth $48.84 Billion by 2019 3Life Science and Chemical Instrumentation Market Worth $48.84 Billion by 2019 4Life Science and Chemical Instrumentation Market Worth $48.84 Billion by 2019 5SCILEX Pharmaceuticals Announces Strategic Investment By ITOCHU CHEMICAL FRONTIER Corporation 2
... May 1 The clinical impact of the first-ever,pro-healing stent, ... at next month,s 16th Annual Scientific Congress of,the Hong Kong ... Sheraton Hong Kong Hotel, the one-hour,session will include:, ... Tse, M.D., of the Hong Kong ...
... Diabetes Association and Richard and Susan Smith Family,Foundation ... ALEXANDRIA, Va., April 30 The American,Diabetes Association ... human type 2 diabetes genes in mice, and ... genetic causes of type 2 diabetes. The,projects will ...
Cached Medicine Technology:Clinical Impact of OrbusNeich's Genous(TM) Bio-engineered R stent(TM) is Subject of Symposium at 16th Annual Scientific Congress of Hong Kong College of Cardiology 2Continued Funding to Help Advance 'Exciting Moment' in Diabetes Research 2
... Rapid exchange thrombectomy never ... with tortuous anatomy in mind, ... cut shaft, soft tip and ... trackability, and pushability. Glide in ...
... Radiometer's 1st automatic is an automated ... samplers and IT to reduce the steps ... operator safety, and minimize errors. The 1st ... arterial sampler, FLEXLINK software, and FLEXQ automatic ...
... three software components that comprise the ... software components comprise the SmartPill GI ... SmartPill Data Receiver software and SmartPill ... integrated and indispensable parts of the ...
... is the new second-generation application software for ... ,This software release includes a range ... efficiency and userfriendliness. Included are automatic tools ... Blood Indicator (SBI) which highlights images that ...
Medicine Products: