Navigation Links
Life savers in the gut
Date:1/9/2008

Researchers from the European Molecular Biology Laboratory (EMBL) have discovered that proteins that regulate the body's iron household play a vital role in making sure enough nutrients and water are absorbed in the intestine. Mice lacking these proteins suffer from weight loss and dehydration, the scientists report in the current issue of Cell Metabolism.

Iron is a central component of red blood cells and has many other important functions throughout the body. Since too little or too much iron is dangerous for our health a range of regulatory proteins tightly controls iron metabolism. EMBL scientists now assessed the role of two of these proteins, iron regulatory proteins 1 and 2 (IRPs), for the first time in living mice and found that their effects are much broader than previously assumed.

We generated the first living organism lacking both IRPs in one of its organs,?says Bruno Galy, who carried out the research in the lab of Matthias Hentze at EMBL. This was extremely challenging, because if both proteins are switched off throughout the whole body, the mouse dies before birth. But if you switch off only one IRP, the one that is still intact substitutes and you can hardly see any effects.?

Surprisingly, the lack of IRPs in the intestine did not upset the mice's iron household in blood and tissues. Instead the mice suffered from other, unexpected problems: they weighed only half of their normal littermates, suffered from severe dehydration and died only 4 weeks after birth. The general nutrient and water absorption in the gut was impaired. A closer look at the intestinal tissues revealed that their structure and organisation were completely disturbed, which likely affects all absorption processes that happen in intestinal cells. The findings show that IRPs are essential for intestinal function and the survival of an organism, but the details of how they accomplish their effects is unclear.

Although the global iron household was unaffected b
'/>"/>

Contact: Anna-Lynn Wegener
anna.wegener@embl.de
49-622-138-78452
European Molecular Biology Laboratory
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Americas Top Hospitals Are Real Lifesavers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... Yisrayl Hawkins, Pastor at The House of ... light of the Ferguson, Missouri unrest. Yisrayl starts his letter ... explains why it has only increased. , He continues ... He says there is a very specific reason for mankind ... is a set of rules, or Laws that if followed ...
(Date:12/26/2014)... 2014 “Many people become overwhelmed by ... claim issues and phone calls with insurance companies,” The ... featuring their free eBook on pedestrian and bicycle ... pedestrian and bicycle auto accident claims assures the injured ... of professionally handling their case while they focus on ...
(Date:12/26/2014)... DW-InductionHeating.com (DaWei Induction Heating Co.) is a ... producing and marketing of a series of induction heating ... new series of induction brazing equipments . , ... induction brazing refers to the joining of two ... heat. The manager says that there are fundamental differences ...
(Date:12/25/2014)... This is a professional and in-depth ... industry with a focus on the Chinese market. The ... the Sterilizers manufacturers and is a valuable source of ... the industry. This report provides a basic overview of ... In this part, the report presents the company profile, ...
(Date:12/25/2014)... The report “TS-1 (Colorectal Cancer) – Forecast and ... landscape, unmet needs, current pipeline and commercial opportunities in ... which is typically used for treating colorectal cancer. It ... gastric cancer and pancreatic cancer. TS-1 is composed of ... approved in 1999 in Japan for the treatment of ...
Breaking Medicine News(10 mins):Health News:Yisrayl Hawkins Pleads for Peace in Ferguson and Beyond in New Open Letter 2Health News:Guide to Handling Pedestrian and Bicycle Accidents Released By The Jones Firm, Featured in Recent Article 2Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 2Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 3Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3
... , PALM SPRINGS, Calif., Aug. 6 ... with Heritage Provider Networks, is highlighted in a USA Today ... a story titled, "Seniors defend Medicare Plan Obama calls ,wasteful," ... on patients to coordinate care and reduce hospital readmissions." , ...
... , , DETROIT, ... of Michigan (BCBSM), the Michigan Attorney General and the Office of ... the Attorney General,s and Office of Financial and Insurance Regulation,s challenge ... nongroup and group conversion products. , , ...
... , KENILWORTH, N.J., Aug. 6 Schering-Plough ... of its Special Shareholders Meeting being held on Friday, August 7, ... and Merck & Co., Inc. Originating from Boston, the Webcast ... site, www.schering-plough.com . , , ...
... A special four-page ... Dr. James Ioli, chief of podiatry at Harvard-affiliated Brigham and Women,s Hospital in Boston, served as ... Boston (Vocus) August 6, ... stand, serve as shock absorbers when we move, and help propel us forward -- and sometimes ...
... BEIJING and BETHESDA, Md., Aug. 6 /PRNewswire-Asia/ -- ... ("Chindex") (Nasdaq: CHDX ), a leading,independent ... in,the People,s Republic of China, today announced that ... plans to,launch a comprehensive, international-standard oncology program, called ...
... , , EATONTOWN, N.J., Aug. 6 Osteotech, ... field of biologic products for regenerative healing, announced today that its ... Annual Global Growth Conference at the InterContinental Hotel in Boston on ... A live, listen-only webcast of the presentation will be ...
Cached Medicine News:Health News:Desert Oasis Healthcare Featured in USA Today 2Health News:Desert Oasis Healthcare Featured in USA Today 3Health News:Desert Oasis Healthcare Featured in USA Today 4Health News:Blue Cross Blue Shield of Michigan, Michigan Attorney General and Michigan Office of Financial and Insurance Regulation Near Agreement on Rate Increases on Under Age 65 Individual Products 2Health News:Harvard Health Letter Special Section Features the Body's Unsung Marvels: The Feet 2Health News:Chindex International, Inc. Launches World-Class Cancer Treatment Center 2Health News:Chindex International, Inc. Launches World-Class Cancer Treatment Center 3Health News:Chindex International, Inc. Launches World-Class Cancer Treatment Center 4
(Date:12/24/2014)... -- In response to urgent requests from the Deputy Minister of ... , Direct Relief delivered two 10-bed medical tents to ... local health workers who contract Ebola while fighting the outbreak. ... was constructed for foreign health care workers who may contract ... Sierra Leonean health workers. With Sierra ...
(Date:12/22/2014)... MONMOUTH JUNCTION, N.J. , Dec. 22, 2014 ... immunotherapy company marketing its CytoSorb® blood purification technology ... cardiac surgery patients in 28 countries worldwide, today ... Di Russo , MD, FACS, as its Senior ... 2015. Dr. Di Russo ...
(Date:12/22/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/h3xm6q/us ) has ... Glucose Market" report to their offering. ... insight focuses on the developments in the self-monitoring blood ... . Reimbursement analysis and the effects of competitive bidding ... 73 SMBG meters have been performed, based on the ...
Breaking Medicine Technology:First Ebola Treatment Unit for Local Health Workers Arrives in Sierra Leone 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5US Self-monitoring Blood Glucose Market 2
... a leader in the pharmaceutical treatment of breathing-control disorders, ... Thomas J. Dietz, Ph.D., as the company,s chairman.  Dr. ... a diversified financial-holdings and services company.   ... and a director of Pacific Growth Equities, LLC, a ...
... YORK, Oct. 26, 2011 Reportlinker.com announces ... available in its catalogue: ... http://www.reportlinker.com/p0158569/Medical-Imaging-Markets-Contrast-Agents.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Imaging The ... are continuing to grow in significance as ...
Cached Medicine Technology:Thomas Dietz, Ph.D., Elected Chairman of Galleon Pharmaceuticals 2Medical Imaging Markets: Contrast Agents 2Medical Imaging Markets: Contrast Agents 3Medical Imaging Markets: Contrast Agents 4Medical Imaging Markets: Contrast Agents 5Medical Imaging Markets: Contrast Agents 6
A highly precise stereotactic radiosurgery system for the treatment of intra-cranial lesions....
The Primus linear accelerator is a fully digital, technologically advanced radiation therapy treatment delivery system. It can be configured for delivery of routine, 3-D conformal or IMRT treatments....
... The cost-effective, proven and reliable ... rates for rapid patient treatment, fastest ... flatness - less than 500 milliseconds, ... highest beam stability, greatest number of ...
The Clinac 2100 C/D family of accelerators are reliable, easy-to-use, flexible and cost-effective systems....
Medicine Products: