Navigation Links
Life-Threatening Leg Clots Run in Families, Study Shows
Date:8/8/2011

By Steven Reinberg
HealthDay Reporter

MONDAY, Aug. 8 (HealthDay News) -- People who have two or more siblings who have suffered blood clots in deep veins such as those in the legs and pelvis -- a disease known as venous thromboembolism (VTE) -- have a relative risk 50 times higher for developing such clots themselves, Swedish researchers report.

Individuals with only one sibling with VTE are two times as likely to suffer the dangerous blood clots.

This is the first study in a large population to show that the risk for VTE runs in families, the researchers say. VTE causes blood clots called deep vein thrombosis, which, if they break loose, can travel to the heart, lungs or brain and, if untreated, tend to be fatal.

"We found genetic factors are important in the risk for VTE," said lead researcher Dr. Bengt Zoller, an associate professor, at the Center for Primary Health Care Research at Lund University in Malmo.

"A sibling history of VTE is an important risk factor for VTE," he said. However, Zoller pointed out that most people who develop a VTE don't have a family history of the condition.

While the relative risk is very high, the absolute risk is much lower. In the general population, the absolute risk for VTE is 3 in 10,000 each year and for those whose family history puts them at high risk it is 15 in 10,000, each year, Zoller said.

The report is published in the Aug. 8 online edition and the Aug. 30 print issue of Circulation.

For the study, Zoller's team collected data on 45,362 people who were hospitalized with VTE. Among these people, 2,393 had a brother or sister who also had a history of the condition.

The researchers found that for those aged 10 to 19 years, there was a five times greater risk of VTE if they had a sibling who had had a VTE, compared with those who didn't have this family history. For older patients, those 60 to 69, the risk was twice as high.

Taking into account age differences between siblings, Zoller's group determined that no environmental factor played a role in the increased risk of VTE.

In addition, while VTE was found in both men and women, the rate was higher among women, especially those 10 to 40 years old. After 50, however, the risk was higher in men than women, the researchers noted.

Risk factors for VTE include surgery, heart failure, smoking, obesity, cancer, long periods of inactivity (such as when driving or flying), sitting or lying in bed, fractures in the legs or hip and taking birth control pills.

Modifying these risk factors can lower your risk for VTE, Zoller said. After heart attack and stroke, VTE is the most common cardiovascular illness and affects one in 1,000 people each year, the researchers said.

Commenting on the study, Dr. Jack Ansell, chairman of the department of medicine at Lenox Hill Hospital in New York City, said that "the study confirms a lot of what we know, but it also provides impetus to greater investigation of genetic and non-genetic factors."

However, Ansell noted that genetics is not the whole story. "There are many individuals with inherited predisposition that never have a problem, so it's not an all or none phenomenon," he said.

Conversely, if you don't have a family history of VTE, that doesn't mean that you will not have one, Ansell said. "There are clearly people who have no risk for a VTE who end up with an event due to acquired factors like an accident or cancer," he said.

This study should not cause people to panic, as the risk for having a VTE is low regardless of family history, Ansell said.

However, he added that people with a family history of VTE should let their doctor know before undergoing any surgery. This will allow the doctor to take preventive measures to prevent the risk of clotting.

More information

For more information on deep vein thrombosis, visit the U.S. National Library of Medicine.

SOURCES: Bengt Zoller, M.D., Ph.D., associate professor, Center for Primary Health Care Research, Lund University, Malmo, Sweden; Jack Ansell, M.D., chairman, department of medicine, Lenox Hill Hospital, New York City; Aug. 8, 2011, Circulation, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Many of those living with HIV face a new life-threatening challenge: cancer
2. How do life-threatening medical conditions in children impact quality of life?
3. Breakthrough in understanding life-threatening childhood liver disease
4. Low blood pressure during dialysis increases risk of clots, according to Stanford-led study
5. Cancer patients with blood clots gain no benefit from adding IVCF to fondaparinux
6. Too Much Sitting May Double Womens Risk of Blood Clots
7. Sitting for long periods doubles risk of blood clots in the lungs
8. Less Invasive Colon Surgery Results in Fewer Blood Clots: Study
9. Risk of blood clots in veins hereditary
10. Scan Technology Tied to Overtreatment of Clots in Lungs
11. Expert Suggests Skipping Pelvis When Scanning for Clots
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Life-Threatening Leg Clots Run in Families, Study Shows 
(Date:8/22/2017)... (PRWEB) , ... August 22, 2017 , ... ... heart-wrenching story of child abuse and neglect, and the struggles faced while hoping ... is the creation of published author, Judy Von Bernewitz, who spent 13 years ...
(Date:8/22/2017)... , ... August 22, 2017 , ... ... Stewart is the Founder and Managing Member for t4 Leadership Development & Consulting. ... critical to his definition of “success”: physician leadership development, servant leadership, data driven ...
(Date:8/22/2017)... ... 22, 2017 , ... Although Labor Day is not as popular for fireworks ... weekend displays, and numerous households celebrate the unofficial end of summer with backyard fireworks ... pets. , Kris Zambo, owner of Dynamite Fireworks in Hammond, Indiana, ...
(Date:8/21/2017)... ... August 22, 2017 , ... The National ... a 2017-2018 inductee into its VIP Woman of the Year Circle. She is ... leading networking organization exclusively for professional women, boasting more than 850,000 members, a ...
(Date:8/21/2017)... ... August 21, 2017 , ... ... has become the Official Technology Partner of North Country Region Volleyball and will ... Systems) volleyball software, along with providing sport management software to their member clubs. ...
Breaking Medicine News(10 mins):
(Date:8/17/2017)... N.J. , Aug. 17, 2017 Bio-Ess Laboratories, LLC Chief ... increase antibody titer and present new data on Cell-Ess® Universal ... in Boston, MA August 21-25.  The Bioprocessing Summit ... today,s bioprocess challenges. ... and Optimizer ...
(Date:8/15/2017)... 2017 AccuGenomics, Inc., a diagnostic company based ... that the company has provided an AccuKit to the ... at Chapel Hill and to Qura Therapeutics for evaluation ... quantify HIV reservoir and viral expression in human CD4+ ... Cure Center is a joint initiative between the University ...
(Date:8/10/2017)... , Aug. 10, 2017  Physical Rehabilitation Network (PRN), acquired ... Lakewood, Colorado . The reputable clinic will ... , PT, DPT with his staff of four clinicians. Lipkin ... Pittsburgh and brings over 10 years of experience with a ... Belmar PT marks the 10th PRN clinic in and around ...
Breaking Medicine Technology: