Navigation Links
Lexicon Initiates Phase 2 Clinical Trial of LX2931 in Patients With Rheumatoid Arthritis
Date:8/4/2009

eased the inflammatory response in multiple models of arthritis, inflammation and transplantation.

The Phase 2 clinical trial is designed as a 12-week, randomized, double-blind, placebo-controlled study to evaluate the safety and tolerability of LX2931 and its effects on symptoms associated with rheumatoid arthritis. The study will include multiple centers in the United States and Eastern Europe. The company expects to enroll up to 120 patients with rheumatoid arthritis on stable methotrexate therapy. Three dose levels will be evaluated: a 70 mg dose, a 110 mg dose and a 150 mg dose, each administered once daily. The primary endpoint will be the ACR20, which is defined by the American College of Rheumatology (ACR) as a 20 percent improvement in symptoms associated with rheumatoid arthritis. Multiple secondary endpoints will also be evaluated, including ACR50, ACR70 and DAS28.

In addition to LX2931, Lexicon has two other drug candidates progressing in Phase 2 clinical trials, LX1031 for irritable bowel syndrome and LX1032 for carcinoid syndrome. Furthermore, LX4211 for diabetes has recently completed dosing in a Phase 1 clinical trial. For more information about Lexicon's clinical development programs, please visit www.lexpharma.com.

About Rheumatoid Arthritis

Lymphocytes are a type of white blood cell that play an important role in the immune system. Inappropriate activation of lymphocytes is often associated with autoimmune diseases, a spectrum of disorders in which the immune system malfunctions and causes the body to attack its own organs, tissues and cells. Rheumatoid arthritis is an autoimmune disorder characterized by stiffness, pain, swelling, and limitation of motion in multiple joints. More than 2 million Americans suffer from rheumatoid arthritis, which, if left untreated, can result in disfigurement and disabilit
'/>"/>

SOURCE Lexicon Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Lexicon Pharmaceuticals Provides Clinical Pipeline Update and Reports 2009 Second Quarter Financial Results
2. Tyco International Increases Quarterly Dividend 36 Percent to 15 Cents per Share; Initiates New $1 Billion Share Repurchase Program
3. Chemical Diversity Initiates International Prostrate Cancer Discovery Partnership
4. Vista Partners Initiates Coverage on Raptor Pharmaceuticals Corp.
5. GenPrime Initiates External Clinical Trials of its Bacterial Contamination Test for Rapid Detection of Bacteria in Platelets
6. U.S. Oncology Initiates Complete Phase Ib Trial of Brostallicin Combination Therapy in Advanced Solid Tumors
7. Harbinger Research Initiates Coverage on HearAtLast
8. Wyeth Consumer Healthcare Initiates Voluntary Recall and Replacement Program for Several Robitussin Products and Childrens Dimetapp Cold & Chest Congestion
9. MAP Pharmaceuticals Initiates Phase 2a Clinical Trial of Combination Therapy in Adult Patients with Asthma
10. Amira Pharmaceuticals Announces Favorable Phase 1 Clinical Trial Results for Lead Product Candidate AM103 and Initiates Clinical Studies for the 2nd Entry Molecule for the Treatment of Respiratory and Cardiovascular Disease
11. Arete Therapeutics Initiates Phase 1 Clinical Trial For AR9281 as a First-in-Class Antihypertensive Agent
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Deer Path of Huntley -- a ... Happy Hour from 3 p.m. to 4 p.m. on Feb. 13. ... Huntley, Illinois, serves adults with physical disabilities between the ages of ... Day treats, games and sweetheart-themed karaoke. , For more information about ...
(Date:1/22/2015)... Liberty University has received accreditation for its resident ... Council for Accreditation of Counseling & Related Educational Programs ... for Counseling & Family Studies , is under the leadership ... School of Behavioral Sciences. Prior to the formation of the ...
(Date:1/22/2015)... 22, 2015 The City of West Hollywood hosted ... to commemorate the 42nd anniversary of the Supreme Court decision Roe ... been 42 years since the Roe vs. Wade decision and the ... present as ever,” said City of West Hollywood Councilmember Abbe Land. ...
(Date:1/22/2015)... 2015 Gabe’s Chemo Duck Program is pleased to ... app ever created for kids with cancer. The Chemo Duck App, ... is filled with enjoyable games to help children of all ages ... app helps to keep kids entertained, educated and at ease while ...
(Date:1/22/2015)... January 23, 2015 VogueQueen is a seasoned ... prices and many designers are thrilled to have it lead ... announces its new collection of prom dresses for the global ... drive the strategic vision and he focuses on continuing the ...
Breaking Medicine News(10 mins):Health News:Deer Path of Huntley Affordable Assisted Living to Host Valentine's Day Happy Hour 2Health News:Liberty University's Resident Master’s Counseling Program Receives CACREP Accreditation 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2
... Thompson HealthDay Reporter , THURSDAY, Dec. 29 (HealthDay ... ranging from crushing depression and crippling anxiety to powerful delusions ... real from the imagined. And if that weren,t enough, ... of the world perceives their inner struggle. Stigma ...
... , THURSDAY, Dec. 29 (HealthDay News) -- Individuals may ... if they carry abnormalities in the so-called "ATM" gene, ... upcoming issue of Cancer Discovery , stems from ... comparative purposes, 190 other individuals who did not have ...
... Dec. 29, 2011--Dr. Andrew Advani, an endocrinologist at St. ... America who received a newly created Novo Nordisk Diabetes ... worth $325,000 (U.S.) over two years. His research ... in patients suffering from diabetes. In diabetic kidney disease, ...
... HealthDay Reporter , WEDNESDAY, Dec. 28 (HealthDay News) ... and vitamins B, C, D and E in their blood ... tended to have larger brain volume, a new study finds. ... blood fared worse on certain thinking tests than those with ...
... Disease-causing strains of the fungus Fusarium are present ... of infection in humans, according to a new study. ... agricultural crops, but some species of the fungus can cause ... example, Fusarium was the cause of an outbreak ...
... crystal-clear tunes at high volume for hours on end ... according to Tel Aviv University research, these advances have also ... teenagers as the most at-risk group. One ... as a direct result of these listening habits, says Prof. ...
Cached Medicine News:Health News:Even Today, the Stigma of Mental Illness Won't Fade 2Health News:Even Today, the Stigma of Mental Illness Won't Fade 3Health News:Gene Mutation May Be Key to Familial Pancreatic Cancer 2Health News:Vitamins, Omega-3s May Keep Brain From Shrinking: Study 2Health News:Vitamins, Omega-3s May Keep Brain From Shrinking: Study 3Health News:Fungus Found in Sinks Can Cause Serious Infections 2Health News:Turn down the iPod to save your hearing 2
(Date:1/23/2015)... , Jan. 23, 2015  CytoSorbents Corporation (NASDAQ ... its CytoSorb® extracorporeal cytokine adsorber to reduce deadly ... the receipt of $385,642, net of transaction costs, ... the Technology Business Tax Certificate Transfer Program sponsored ...
(Date:1/22/2015)... a privately held medical device company, announced today that ... ITOCHU Corporation (Tokyo Stock Exchange TYO: 8001) to sell ... cancer in Japan . ViewRay,s technology, ... only MRI-guided radiation therapy system that images and treats ...
(Date:1/22/2015)... Jan. 22, 2015  Amgen (NASDAQ: AMGN ) today announced ... financial results on Tuesday, Jan. 27, 2015, after the close of ... conference call with the investment community at 2 p.m. PT. Participating ... , chairman and chief executive officer, and other members of Amgen,s ...
Breaking Medicine Technology:CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2
... South Dakota pharmaceutical company, pharmaCline ™ , has launched ... statement.  On November 23, 2011, pharmaCline became a part ... spot on the CBS jumbo screen located in Times ... through January 1, 2012. (Logo:  http://photos.prnewswire.com/prnh/20111202/MN16158LOGO ...
... Dec. 1, 2011 Demands from senior management ... commercial functions searching for best-in-class organizational structures. Comparing ... in place at peer companies through benchmarking data ... To support pharmaceutical vice presidents, directors, ...
Cached Medicine Technology:pharmaCline Launches "pharmaCline Can Help" Campaign 2Organizational Design and Structure Benchmarks for Pharmaceutical Commercial Functions Accessed Quickly Through Best Practices, LLC's New Database Search Function 2
DiaMed-ID Micro Typing System...
ScanGel® Incubator...
... Three different sized High-Throughput Submarine Systems ... of samples from microtitre plates. Analyze ... fragments, synthetic oligos or PCR products ... pipetting for accuracy and speed with ...
... The Mini-PROTEAN 3 Dodeca cell runs up ... in just 35 minutes. Handcast gels can ... the new Model 485 gradient former and ... variation and improving reproducibility. Alternatively, Ready Gel ...
Medicine Products: