Navigation Links
Lexicon Initiates Phase 2 Clinical Trial of LX2931 in Patients With Rheumatoid Arthritis
Date:8/4/2009

THE WOODLANDS, Texas, Aug. 4 /PRNewswire-FirstCall/ -- Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX), a biopharmaceutical company focused on discovering and developing breakthrough treatments for human disease, announced today that it has initiated a Phase 2 clinical trial of LX2931 in patients with rheumatoid arthritis. LX2931 is an orally-delivered, small molecule drug candidate that has recently completed Phase 1 testing in normal volunteers. Lexicon also successfully completed a drug-drug interaction (DDI) study of LX2931 with methotrexate in patients with rheumatoid arthritis, with no clinically significant drug-drug interactions observed.

"We believe that, as an oral therapy, LX2931 could have advantages over current biologic therapies in treating patients with rheumatoid arthritis," said Philip M. Brown, M.D., J.D., senior vice president of clinical development at Lexicon. "LX2931 has demonstrated potent anti-inflammatory activity in preclinical models of arthritis and inflammation and, importantly, has been well tolerated in combination with methotrexate, the current standard of care first-line therapy."

LX2931 inhibits sphingosine-1-phosphate (S1P) lyase, an enzyme identified by Lexicon scientists as a promising new target on a pathway associated with regulation of the human immune system. Lexicon has previously shown that genetically "knocking out" or "knocking down" S1P lyase in mice substantially decr
'/>"/>

SOURCE Lexicon Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Lexicon Pharmaceuticals Provides Clinical Pipeline Update and Reports 2009 Second Quarter Financial Results
2. Tyco International Increases Quarterly Dividend 36 Percent to 15 Cents per Share; Initiates New $1 Billion Share Repurchase Program
3. Chemical Diversity Initiates International Prostrate Cancer Discovery Partnership
4. Vista Partners Initiates Coverage on Raptor Pharmaceuticals Corp.
5. GenPrime Initiates External Clinical Trials of its Bacterial Contamination Test for Rapid Detection of Bacteria in Platelets
6. U.S. Oncology Initiates Complete Phase Ib Trial of Brostallicin Combination Therapy in Advanced Solid Tumors
7. Harbinger Research Initiates Coverage on HearAtLast
8. Wyeth Consumer Healthcare Initiates Voluntary Recall and Replacement Program for Several Robitussin Products and Childrens Dimetapp Cold & Chest Congestion
9. MAP Pharmaceuticals Initiates Phase 2a Clinical Trial of Combination Therapy in Adult Patients with Asthma
10. Amira Pharmaceuticals Announces Favorable Phase 1 Clinical Trial Results for Lead Product Candidate AM103 and Initiates Clinical Studies for the 2nd Entry Molecule for the Treatment of Respiratory and Cardiovascular Disease
11. Arete Therapeutics Initiates Phase 1 Clinical Trial For AR9281 as a First-in-Class Antihypertensive Agent
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... A new report launched today by the Intellectual ... on Ageing) conducted by academics from the School ... has highlighted the serious, complex and unique health ... , The IDS-TILDA study is the first study ... one in the world with the ability to ...
(Date:9/30/2014)... September 30, 2014 SIMpalm, the top ... iPhone App for another great social networking music sharing ... App for iPhone®, iPad®, and iPod touch®. The App ... of music from their pre-populated ITunes account. This app ... song’s album art or photo of their choice to ...
(Date:9/30/2014)... 30, 2014 MyServer2Go.com made ... the Best VPS Hosting this year for its quality ... affordable price. , MyServer2Go.com is a professional and ... hosting services. And this announcement will help webmasters find ... to MyServer2Go.com, Arvixe ( http://www.arvixe.com ) is one of ...
(Date:9/30/2014)... The Buffet Restaurants industry ... drop in industry revenue in 2009, the industry has ... has been negatively affected by low levels of consumer ... presented itself in the form of increasing health consciousness. ... tend to use lower quality ingredients in the food ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 The ... to improve breast cancer risk prediction and to ... a study published in Breast Cancer Research (BCR ... density and breast cancer risk: a case-control study ... strong connection between breast density and breast cancer ...
Breaking Medicine News(10 mins):Health News:Longitudinal report shows challenging reality of ageing with an intellectual disability 2Health News:Longitudinal report shows challenging reality of ageing with an intellectual disability 3Health News:Longitudinal report shows challenging reality of ageing with an intellectual disability 4Health News:LYRICZ App for iPhone®, Helps You Share Images with Music to Inspire and Influence 2Health News:Arvixe Is Named Best VPS Hosting by MyServer2Go.com 2Health News:Buffet Restaurants in the US Industry Market Research Report Now Available from IBISWorld 2Health News:Buffet Restaurants in the US Industry Market Research Report Now Available from IBISWorld 3Health News:Mammographic Density Offers Potential to Improve Prediction of Breast Cancer Risk and Development of Personalized Screening 2Health News:Mammographic Density Offers Potential to Improve Prediction of Breast Cancer Risk and Development of Personalized Screening 3Health News:Mammographic Density Offers Potential to Improve Prediction of Breast Cancer Risk and Development of Personalized Screening 4
... the Canadian Institute of Medicine it was found that fat formed ... lack a balanced diet which in turn results in various ill ... daily calories from fat which is the main cause of various ... people and questioned them about their food habits. ,Statistics ...
... from schools have met with criticism from anti-obesity lobby ... to make all schools to be soft drink-free by ... described as "misguided and based on weak evidence" by ... physicians at Starship and Auckland University. ,Professor ...
... 55 others were afflicted with the disease in Chhajli village ... an eight-year-old boy and aged woman and illness of others ... Medical teams were pressed into service today., ,Civil Surgeon ... rushed to the village to educate the people about preventive ...
... for their aches and pains could be at an ... of a new study// . ,Researchers said ... dose of acetaminophen showed abnormalities in blood tests, which ... had come across liver damage in patients who took ...
... institutes and increase the number of seats in existing facilities ... well as accommodate// the central government's proposed quota policy, says ... of seats in medical institutions and open more institutes in ... more than 4,000 doctors and this was the only to ...
... the Calcutta High Court claiming that the failure of West ... directives in keeping the metropolis clean had led to the ... has died and several others are suffering from dengue with ... ,The petitioner's lawyer Idris Ali claimed before a division ...
Cached Medicine News:Health News:Anti-Obesity Groups Criticize Response of Medical Professionals 2Health News:Even Normal Doses Of Tylenol Could Damage Liver 2
(Date:9/30/2014)... SAN DIEGO , Sept. 30, 2014   ... company developing a minimally invasive real-time 3D Cardiac Chamber ... sources that cause and / or sustain complex cardiac ... additional $26.2M financing to continue developing its imaging/mapping system ... portfolio.  The financing will allow Acutus Medical to complete ...
(Date:9/30/2014)... , Sept. 30, 2014  Life Science ... focused on supporting promising emerging biotech, medical device, ... named the Top Angel Investment Group in the ... the best performer out of 370 angel groups ... performance, network strength (connections), selection aptitude and brand ...
(Date:9/30/2014)... , Sept. 30, 2014  Synapse Biomedical Inc. ( ... enrollment of the post-approval study of its NeuRx ... needed to meet the FDA enrollment requirement was ... of schedule.  The NeuRx DPS®, which is the ... for ALS patients, is a humanitarian device that ...
Breaking Medicine Technology:Acutus Medical, Inc. Completes Additional $26.2M Series B Financing to Fund Portfolio Expansion 2Acutus Medical, Inc. Completes Additional $26.2M Series B Financing to Fund Portfolio Expansion 3Life Science Angels Ranked the Top Angel Investment Group in the U.S. 2Life Science Angels Ranked the Top Angel Investment Group in the U.S. 3Synapse Biomedical Announces the Early Completion of Enrollment in the FDA Post Approval Study for ALS Patients 2Synapse Biomedical Announces the Early Completion of Enrollment in the FDA Post Approval Study for ALS Patients 3
... 12 Today at the annual AdvaMed medical ... of Good Promotional Practices software, announced a partnership ... and case management solutions. Together, the companies will ... help Life Sciences companies cope with the myriad ...
... Merial, the Animal Health division of the sanofi-aventis Group (EURONEXT: ... Animal Health Co. (China) held a ground-breaking ceremony for an ... Development Zone, China. Merial Animal Health Co. (China), a ... in China has been in operation for almost 20 years. ...
Cached Medicine Technology:Prolifiq and EthicsPoint Announce Partnership: 'Automatic Alerts' Help Life Sciences Engage in Good Promotional Practices 2Prolifiq and EthicsPoint Announce Partnership: 'Automatic Alerts' Help Life Sciences Engage in Good Promotional Practices 3Merial invests US $70 million in Nanchang, China 2Merial invests US $70 million in Nanchang, China 3
Used for the retrieval of stones, stents, or other objects in the urinary tract under direct vision. Retrieval Forceps are designed for use through rigid or flexible endoscopes. Supplied sterile in p...
... technology allows the grasper ... a shorter length and ... the stone. The Unidex ... one-handed operation. Supplied sterile ...
Bugbee Fulgurating...
Fulgurating Electrode, 2 F...
Medicine Products: