Navigation Links
Levels of Circulating Tumor Cells Could Predict Prostate Cancer Outcome
Date:2/11/2009

New method of tracking changes proves better predictor than PSA, study says

WEDNESDAY, Feb. 11 (HealthDay News) -- Checking for changes in the number of circulating tumor cells (CTCs) could help doctors predict advanced prostate cancer patients' survival and response to treatment, U.S. researchers report.

They studied the association between CTC numbers (before and after treatment) and survival, along with other factors such as changes in levels of prostate-specific antigen (PSA) and baseline lactate dehydrogenase (LDH) in 164 prostate cancer patients starting first-line chemotherapy regimens.

High values of CTC numbers and PSA levels before treatment were associated with increased risk of death. At four, eight and 12 weeks after treatment, changes in CTC numbers were strongly associated with increased risk of death, while changes in PSA were only marginally associated with increased risk of death.

The findings confirm that pre-treatment CTC numbers help predict survival of prostate cancer patients starting first-line chemotherapy. CTC numbers also help monitor disease status and response to treatment, and CTC is a better predictor than PSA, the researchers said.

"CTC number[s] ... can be used to monitor disease status and might be useful as an intermediate endpoint of survival in clinical trials," wrote study author Howard Sher, of Memorial Sloan-Kettering Cancer Center in New York City. "Use as an intermediate or surrogate endpoint for survival could shorten the time line for drug approval," although "several prospective trials are needed to generate evidence to guide the use of biomarkers."

The study was published online and will appear in the March print issue of The Lancet Oncology.

More information

The American Cancer Society has more about prostate cancer.



-- Robert Preidt



SOURCE: The Lancet Oncology, news release, Feb. 10, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Low Humidity Levels Help Flu Germs Spread
2. Pathologically elevated blood fat levels in obesity: Researchers discover molecular causes
3. HPV18 DNA levels are not prognostic for precancerous cervical lesions
4. New Study: Higher DHA Levels Improve Neurodevelopmental Outcomes in Premature Girls
5. Children with inflammatory bowel disease have surprisingly high folate levels, study finds
6. Children with Inflammatory Bowel Disease Have Surprisingly High Folate Levels, Study Finds
7. Women in Coastal Areas Have Higher Mercury Levels
8. Cholesterol Levels May Not Measure Cardiac Risk
9. Most heart attack patients cholesterol levels did not indicate cardiac risk
10. High insulin levels raise risk of breast cancer in postmenopausal women
11. Government at all Levels Will Continue to Spend on Essential Services and Invest in the Future, According to Onvia Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Levels of Circulating Tumor Cells Could Predict Prostate Cancer Outcome
(Date:6/25/2016)... FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial ... Plant City Observer , brings up a new, often overlooked aspect of head lice: the ... closing for fumigation is not a common occurrence, but a necessary one in the event ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room ... Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. ... of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, ... the latter, setting the bar too high can result in disappointment, perhaps even self-loathing. ... toward their goal. , Research from PsychTests.com reveals that behind the ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set of ... or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, Serenity ... event. , Trauma sufferers tend to feel a range of emotions, from depression, guilt, ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... Jazz Pharmaceuticals plc (Nasdaq: JAZZ ... Antitrust Improvements Act of 1976, as amended ("HSR"), with ... ("Celator"; Nasdaq: CPXX ) expired effective June ... As previously announced on May 31, 2016, Jazz ... under which Jazz Pharmaceuticals has commenced a tender offer ...
(Date:6/26/2016)... 2016 Story Highlights: ... within the health care industry is causing providers to ... , Deloitte offers a suite of solutions for health ... efficient cost optimization: labor resource analysis, revenue cycle optimization ... better outcomes and better economics ...
(Date:6/24/2016)... 24, 2016  Collagen Matrix, Inc., ("Collagen Matrix") ... manufacturing of collagen and mineral based medical devices ... Bill Messer has joined the company ... leverage the growing portfolio of oral surgery, neurosurgery, ... Bill joins the Collagen Matrix executive team as ...
Breaking Medicine Technology: