Navigation Links
Levels of Circulating Tumor Cells Could Predict Prostate Cancer Outcome

New method of tracking changes proves better predictor than PSA, study says

WEDNESDAY, Feb. 11 (HealthDay News) -- Checking for changes in the number of circulating tumor cells (CTCs) could help doctors predict advanced prostate cancer patients' survival and response to treatment, U.S. researchers report.

They studied the association between CTC numbers (before and after treatment) and survival, along with other factors such as changes in levels of prostate-specific antigen (PSA) and baseline lactate dehydrogenase (LDH) in 164 prostate cancer patients starting first-line chemotherapy regimens.

High values of CTC numbers and PSA levels before treatment were associated with increased risk of death. At four, eight and 12 weeks after treatment, changes in CTC numbers were strongly associated with increased risk of death, while changes in PSA were only marginally associated with increased risk of death.

The findings confirm that pre-treatment CTC numbers help predict survival of prostate cancer patients starting first-line chemotherapy. CTC numbers also help monitor disease status and response to treatment, and CTC is a better predictor than PSA, the researchers said.

"CTC number[s] ... can be used to monitor disease status and might be useful as an intermediate endpoint of survival in clinical trials," wrote study author Howard Sher, of Memorial Sloan-Kettering Cancer Center in New York City. "Use as an intermediate or surrogate endpoint for survival could shorten the time line for drug approval," although "several prospective trials are needed to generate evidence to guide the use of biomarkers."

The study was published online and will appear in the March print issue of The Lancet Oncology.

More information

The American Cancer Society has more about prostate cancer.

-- Robert Preidt

SOURCE: The Lancet Oncology, news release, Feb. 10, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Low Humidity Levels Help Flu Germs Spread
2. Pathologically elevated blood fat levels in obesity: Researchers discover molecular causes
3. HPV18 DNA levels are not prognostic for precancerous cervical lesions
4. New Study: Higher DHA Levels Improve Neurodevelopmental Outcomes in Premature Girls
5. Children with inflammatory bowel disease have surprisingly high folate levels, study finds
6. Children with Inflammatory Bowel Disease Have Surprisingly High Folate Levels, Study Finds
7. Women in Coastal Areas Have Higher Mercury Levels
8. Cholesterol Levels May Not Measure Cardiac Risk
9. Most heart attack patients cholesterol levels did not indicate cardiac risk
10. High insulin levels raise risk of breast cancer in postmenopausal women
11. Government at all Levels Will Continue to Spend on Essential Services and Invest in the Future, According to Onvia Study
Post Your Comments:
Related Image:
Levels of Circulating Tumor Cells Could Predict Prostate Cancer Outcome
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
(Date:6/25/2016)... ... , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors ... Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green ... hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may ... to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To ... for healthy coping following a traumatic event. , Trauma sufferers tend to feel a ...
(Date:6/24/2016)... Francisco, CA (PRWEB) , ... June 24, 2016 ... ... CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive ... self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon and ... women in the world, and the most handsome men, look naturally attractive. Plastic ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... HILL, N.C. , June 24, 2016 /PRNewswire/ ... healthcare decisions and regulators/payers have placed more emphasis ... new environment, patient support programs in the pharmaceutical ... for patients, medications. Consequently, pharmaceutical companies are focusing ... ensure they are providing products and services that ...
(Date:6/24/2016)... , June 24, 2016  Global Blood ... biopharmaceutical company developing novel therapeutics for the treatment ... today announced the closing of its previously announced ... stock, at the public offering price of $18.75 ... offering were offered by GBT. GBT estimates net ...
(Date:6/24/2016)... June 24, 2016 ... announced the addition of the " Global Markets ... This report focuses ... an updated review, including its applications in various applications. ... market, which includes three main industries: pharmaceutical and biotechnology, ...
Breaking Medicine Technology: