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Leukocyte reduction seen as significant advance in transfusion medicine
Date:10/15/2007

tenuation of Infection Risks among Transfusion Recipients presents evidence of the benefits of leukocyte reduction beyond its established role in reducing fever, transmission of cytomegalovirus (CMV) and preventing alloimmunization, the formation of antibodies that can prevent the body from accepting a platelet transfusion. Joseph S. Cervia, M.D., Clinical Professor of Medicine & Pediatrics, Albert Einstein College of Medicine, New York City and Medical Director of Pall Medical and colleagues authored the review article. Pall Corporation (NYSE: PLL) pioneered the development of leukocyte reduction with filtration.

A significant percentage of the population harbors latent infection-causing bacteria and viruses that, without leukocyte reduction, may be transmitted during a blood transfusion but not show up until years, even decades, later. Analysis of recent studies suggest that leukocyte reduction may be effective in reducing the risk of transmission of a number of transfusion-transmitted infectious agents, including herpes viruses, such as Epstein Barr; retroviruses, such as HTLV-1 and HIV; and other emerging threats. These emerging pathogens include bacteria, such as Yersinia enterocolitica; protozoa such as Leishmania species and Trypanosoma cruzi; and infectious prions, believed to be the cause of several fatal neurodegenerative diseases, including variant Creutzfeldt-Jakob Disease (vCJD), commonly known as the human form of mad cow disease.

The authors point out that leukocyte reduction may reduce the risk of transfusion-related immunomodulation (TRIM), depression of the immune system which may predispose a patient to post-operative infection. Drs. Blumberg and Heal describe blood transfusion as temporary organ transplantation, noting that blood that has not been leukocyte reduced has the potential for profound, long-term adverse effects on the immune systems ability to fight disease.

They conclude, All treating physicians sho
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Contact: Marcia Katz
marcia_katz@pall.corm
516-801-9851
Pall Corporation
Source:Eurekalert

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