Navigation Links
Leukemia therapy with imatinib during pregnancy may cause infant abnormalities
Date:3/5/2008

eveloped kidney), and hemivertebrae (underdeveloped spine). The stillborn child suffered from meningocoele (cerebral hernia).

The study showed that a significant proportion of pregnancies exposed to imatinib result in a normal outcome and a healthy infant. The miscarriage rate in the study was 14.4 percent, which is within the expected range for the general population. However, the fact that some of the abnormalities seen in the 12 infants were similar to results found in early animal studies with imatinib suggests the possibility of an imatinib-induced effect.

"Our study suggests that a concern about conceiving a child while taking imatinib is justified and that patients should be advised to avoid conception while on treatment," said Dr. Seonaid Pye, of the Department of Hematology, Imperial College of London and lead author of the study. "In those patients who do become pregnant, balancing the risk of the fetus from taking therapy to the risk of the mother from interrupting therapy will be an individual decision."

The majority of women in the study were being treated for CML at the time of conception; just four cases were exposed after the first trimester. The dose and the exact duration of imatinib therapy are unknown for most cases, with insufficient information to assess a dose-related relationship. There were no reports of maternal exposure to alcohol, drugs, or tobacco addiction during pregnancy, and none of the mothers had received other high-dose chemotherapy prior to their pregnancies.

"The risks and benefits to an expectant woman fighting cancer and her fetus are challenging and must be evaluated on an individual basis with careful counseling," said Dr. Pye. "Ultimately, the treatment of CML during pregnancy clearly remains a considerable clinical challenge."


'/>"/>

Contact: Becka Livesay
rlivesay@hematology.org
202-776-0544
American Society of Hematology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. The Leukemia & Lymphoma Society Hosts Workshop On Weighing Treatment Options For Chronic Myelogenous Leukemia
2. Study finds heart failure is rare among leukemia patients on imatinib
3. Altered expression of ultraconserved noncoding RNAs linked to human leukemias and carcinomas
4. Cephalon Submits New Drug Application for TREANDA for the Treatment of Chronic Lymphocytic Leukemia
5. FDA Approves Expanded Labeling for Campath(R) to Include First-line Treatment for Leading Form of Adult Leukemia
6. Novel strategy under study for aggressive leukemia
7. Drug has ability to cure type of leukemia
8. The Leukemia & Lymphoma Society Provides Patients with the Latest Information on Myeloma
9. Micromet Receives Regulatory Approval to Conduct a Phase 2 Clinical Trial Investigating MT103 (MEDI-538) in Patients with Acute Lymphoblastic Leukemia
10. Video and Photo: Tasigna(R) Receives US Approval Providing New Hope to Chronic Myeloid Leukemia Patients With Resistance or Intolerance to Existing Therapies
11. St. Jude Finds Anti-Leukemia Drug Increases Patient Fatigue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... Give a loved one the greatest gift ... and vitality. , For a limited time, HealthiPlus ( ... in special Holiday Wellness gift packages at drastically reduced ... bottle contains cutting-edge, proven nutritional support for joints, mental ... as we age. , Joint Health Plus ...
(Date:12/22/2014)... December 22, 2014 Pasadena sleep ... consultations for sleep apnea. Drowsy drivers are 15 times ... who are well-rested, and some experts believe that sleep-deprived ... as intoxicated drivers. Unfortunately, millions of Americans may be ... Academy of Sleep Medicine, about 18 million Americans have ...
(Date:12/22/2014)... Branch, TX (PRWEB) December 22, 2014 ... revolutionary work glove with many useful features. Customers of ... and can have the new gloves delivered to their ... work gear and hand tools that incorporate heavy duty ... Utility Magnetic Glove allows workers to store metal parts ...
(Date:12/22/2014)... December 22, 2014 NAPW ... Professional Woman of the Year. Ms. Foley is recognized ... the largest, most-recognized networking organization of professional women in ... National Association of Professional Women is a powerfully vibrant ... Local Chapters. , “As a nurse, I felt like ...
(Date:12/22/2014)... 2014 The NLN’s 2015 ... programs this month. Faculty have been selected through ... educators fast-tracked for administrative leadership roles within their ... for Simulation Educators, featuring a curriculum uniquely devised ... education. , Twenty nurse educators were chosen ...
Breaking Medicine News(10 mins):Health News:You Still Have Time to Give the Gift of Health and Vitality to a Mature Loved One 2Health News:Pasadena Dentist, Dr. Marine Martirosyan, Now Offers Consultations for Sleep Apnea 2Health News:MagnoGrip Pro Utility Magnetic Gloves on Sale at TheHardwareCity.com 2Health News:National Association of Professional Women Announces Michelle M. Foley, Vice President of Operations of OTTR Chronic Care Solutions, a 2014 Professional Woman of the Year 2Health News:NLN Leadership Institute Announces 2015 Cohorts 2Health News:NLN Leadership Institute Announces 2015 Cohorts 3
... to researchers, new bandages developed by US researchers take ... mice show that hydrogel bandages speed up healing.They look ... times and become pliable when wet.// Unlike regular bandages, ... hydrogel dressings actually penetrate the wound and enhance the ...
... have observed that, people suffering from heat diseases are better ... but for a few it might prove too much.People who ... still safe to enjoy a game of golf.// Researchers at ... 15 male golfers, aged between 50 and 75, half of ...
... studied on African tribe, most of the things being equal ... to be healthier for the heart than eating a vegetarian ... the body control blood levels of leptin,// a substance secreted ... increased risk for heart attack and stroke. ,Lead author ...
... has found that caffeine is often used to treat ... is a condition characterized by cessation in breathing and ... growing concern over caffeine's effects on a baby's circulatory ... caffeine on cardiac output, specifically studying the effects on ...
... important tips regarding splitting a pill and ways of taking care ... a whole one. one might be neglecting off a medication, or ... way, you may need to split a pill into two or ... some advice on how to go about pill splitting. First, you ...
... offer some valuable advice on how to make sure your ... bones and teeth, and helps prevent osteoporosis and any bone ... produce vitamin D.// Just10 to 15 minutes of natural sunlight ... many factors can reduce sunlight exposure, such as windows, sunscreen, ...
Cached Medicine News:Health News:Fish rich diet lowers leptin 2Health News:Caffeine reduces infant blood flow 2
(Date:12/19/2014)... TODAY, AEGATE, the leader in ... the appointment of Peter Fox as Chief ... and Partner Officer. Peter has served as ... acquisition by Oracle in 2011. Prior to ... and subsequently Convergys, a world renowned billing ...
(Date:12/19/2014)... Dec. 19, 2014   Hospira, Inc. (NYSE: ... injectable drugs and infusion technologies, today announced that the ... Healthcare Conference on Wednesday, Jan. 14, 2015, in ... to begin at 10:30 a.m. Pacific time on Wednesday, ... interested parties through a live audiocast accessible via the ...
(Date:12/19/2014)... WORTH, Texas , December 18, 2014 /PRNewswire/ ... a networked software application/module that is used to ... related images. RIS comprises a patient tracking and ... system. The integration of RIS with HIS and ... used for patient registration and patient scheduling, patient ...
Breaking Medicine Technology:Aegate Appoints new CTO and Chief Channels & Partner Officer 2Aegate Appoints new CTO and Chief Channels & Partner Officer 3Aegate Appoints new CTO and Chief Channels & Partner Officer 4The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 2The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 3
... 9, 2012 GlySure Limited, developer of ... close of its $10.9 million Series C financing round. ... to supportregulatory approval in the United States and Europe. ... Venture, as well as existing investors Amadeus Capital Partners, ...
... FORD, Pa., Jan. 9, 2012 Endo Pharmaceuticals (Nasdaq: ... result of a temporary shut-down of Novartis Consumer Health ... short-term supply constraint of OPANA® ER.  The company also ... facility may experience short-term supply disruptions.  Endo is working ...
Cached Medicine Technology:GlySure Secures $10.9 Million in Series C Financing Round 2Endo Announces Potential Short-Term Supply Constraints of Certain Analgesic Medications as a Result of Temporary Shut Down of Novartis Facility 2Endo Announces Potential Short-Term Supply Constraints of Certain Analgesic Medications as a Result of Temporary Shut Down of Novartis Facility 3
The Maverick Over-The-Wire balloon catheter delivers a new level of performance to meet the changing demands of interventional cardiology....
The Maverick Over-The-Wire balloon catheter delivers a new level of performance to meet the changing demands of interventional cardiology....
... Phoroptor features lighted dials to make it ... in the darkened setting of the exam ... leave the lights off throughout the entire ... cylinder power and cylinder axis scales that ...
... The Reichert CT200 Tonometer ... the XCEL 250 and XCEL ... also compatible with other Zeiss-style ... mounted on the top of ...
Medicine Products: