Navigation Links
Leukemia stem cells have more in common with embryonic stem cells than adult stem cells
Date:2/5/2009

Research using a mouse model of human leukemia has provided critical insight into the genetic factors related to the generation and maintenance of myeloid leukemia stem cells. The study, published by Cell Press in the February 6th issue of the journal Cell Stem Cell, is likely to have a profound impact on the future design of therapeutic approaches targeted against cancer stem cells.

Leukemia stem cells (LSCs) were initially described as rare cells that share characteristics with normal hematopoietic stem cells (HSCs). HSCs are a type of partially committed adult stem cells that can give rise to multiple types of blood cells. However, recent research has demonstrated that LSCs can represent a significant fraction of leukemic cells and exhibit characteristics associated with more mature, differentiated myeloid cells rather than the more versatile HSCs.

"Since LSCs may be more numerous and mature than originally proposed, the nature and generality of the hierarchical organization of malignancies has recently been questioned," says senior study author Dr. Michael L. Cleary, from the Department of Pathology at Stanford University. Dr. Cleary and colleagues used a mouse model of human AML to investigate the genes that maintain LSC frequencies and leukemia cell hierarchies.

The researchers found that LSCs are maintained in a self-renewing state by subversion of a transcriptional program that shares features with pluripotent embryonic stem cells (ESCs). This transcriptional program is transiently expressed in normal myeloid precursor cells rather than HSCs or fully mature white blood cells. The authors go on to reveal a link between activation of genes associated with ESCs at an inappropriate stage of white blood cell development, the number of LSCs, and a poor prognosis in leukemia.

"Importantly, the shared transcriptional features of LSCs, ESCs, normal mid-myeloid lineage cells, and a diverse set of poor-prognosis human malignancies support the broader conclusion that cancer stem cells may be aberrantly self-renewing downstream progenitor cells," explains lead study author Dr. Tim Somervaille.

The study also highlights the potential of therapeutic strategies aimed at genes and pathways that are of greater importance to the function of LSCs than HSCs. "These findings may have a substantial clinical impact, as normal HSCs are necessary for regeneration of hematopoiesis following chemotherapy," offers Dr. Cleary.


'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Related medicine news :

1. St. Jude finds more than 100 gene variations linked with response to leukemia treatment
2. In Kids, Genes May Affect Leukemia Treatment
3. New study aims to reduce risk of childhood leukemia
4. Hard-to-Treat Leukemia Cell Subtype Identified
5. Dana-Farber Researcher Named Millennium Pharmaceuticals Career Development Scholar of The Leukemia & Lymphoma Society
6. Childhood Leukemia Subtype Resists Treatment
7. Gene Governs Response to Leukemia Chemotherapy
8. Gene abnormality found to predict childhood leukemia relapse
9. The Leukemia & Lymphoma Society and The University of Kansas Cancer Center Announce Innovative Partnership to Accelerate Drug Development
10. Grape Seed Extract Kills Leukemia Cells in Lab
11. Stem cells and leukemia battle for marrow microenvironment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... March 24, 2017 , ... Northridge ... now offering treatments for sleep apnea and TMJ at their office. TMJ, or ... , specifically the obstructive type, is increasingly being treated at dental offices with ...
(Date:3/24/2017)... ... 2017 , ... Empower Brokerage, located in Southlake, Texas, intends ... , In February, 2017, Empower Brokerage introduced their new “Performance Partners” program to ... teach how to maximize their sales efforts, as well as how to best ...
(Date:3/24/2017)... ... March 24, 2017 , ... “The Communion of Saints: A ... God in congregations across the United States. “The Communion of Saints” is ... who has served congregations in seven states throughout his long career of devotion ...
(Date:3/23/2017)... ... March 23, 2017 , ... Demonstrating their commitment ... more public health departments have been awarded national accreditation through the Public ... into the expanding network of communities across the nation whose health departments meet ...
(Date:3/23/2017)... ... March 23, 2017 , ... 82% of adults are unaware of the dangers that ... brush their teeth the minimum two times a day that dentists recommend. The ramifications of ... million hours of school and adults missing 164 million hours of work each year due ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... , March 24, 2017 Global ... industry including definitions, classifications, applications and industry chain structure. ... market including development history, competitive landscape analysis, and major ... ... spread across 105 pages providing 10 company profiles and ...
(Date:3/24/2017)... DUBLIN , Mar 24, 2017 Research ... Supplies - Global Strategic Business Report" report to their offering. ... The report provides separate comprehensive ... , Europe , Asia-Pacific , ... and forecasts are provided for the period 2015 through 2022. Also, a ...
(Date:3/24/2017)... INDIANAPOLIS , March 24, 2017  Eli ... today announced plans to invest $850 million in ... span facilities across its U.S. enterprise, including research ... The investments are being driven by demand for ... of potential medicines in development targeting cancer, pain, ...
Breaking Medicine Technology: