Navigation Links
Leukemia stem cells have more in common with embryonic stem cells than adult stem cells
Date:2/5/2009

Research using a mouse model of human leukemia has provided critical insight into the genetic factors related to the generation and maintenance of myeloid leukemia stem cells. The study, published by Cell Press in the February 6th issue of the journal Cell Stem Cell, is likely to have a profound impact on the future design of therapeutic approaches targeted against cancer stem cells.

Leukemia stem cells (LSCs) were initially described as rare cells that share characteristics with normal hematopoietic stem cells (HSCs). HSCs are a type of partially committed adult stem cells that can give rise to multiple types of blood cells. However, recent research has demonstrated that LSCs can represent a significant fraction of leukemic cells and exhibit characteristics associated with more mature, differentiated myeloid cells rather than the more versatile HSCs.

"Since LSCs may be more numerous and mature than originally proposed, the nature and generality of the hierarchical organization of malignancies has recently been questioned," says senior study author Dr. Michael L. Cleary, from the Department of Pathology at Stanford University. Dr. Cleary and colleagues used a mouse model of human AML to investigate the genes that maintain LSC frequencies and leukemia cell hierarchies.

The researchers found that LSCs are maintained in a self-renewing state by subversion of a transcriptional program that shares features with pluripotent embryonic stem cells (ESCs). This transcriptional program is transiently expressed in normal myeloid precursor cells rather than HSCs or fully mature white blood cells. The authors go on to reveal a link between activation of genes associated with ESCs at an inappropriate stage of white blood cell development, the number of LSCs, and a poor prognosis in leukemia.

"Importantly, the shared transcriptional features of LSCs, ESCs, normal mid-myeloid lineage cells, and a diverse set of poor-prognosis human malignancies support the broader conclusion that cancer stem cells may be aberrantly self-renewing downstream progenitor cells," explains lead study author Dr. Tim Somervaille.

The study also highlights the potential of therapeutic strategies aimed at genes and pathways that are of greater importance to the function of LSCs than HSCs. "These findings may have a substantial clinical impact, as normal HSCs are necessary for regeneration of hematopoiesis following chemotherapy," offers Dr. Cleary.


'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Related medicine news :

1. St. Jude finds more than 100 gene variations linked with response to leukemia treatment
2. In Kids, Genes May Affect Leukemia Treatment
3. New study aims to reduce risk of childhood leukemia
4. Hard-to-Treat Leukemia Cell Subtype Identified
5. Dana-Farber Researcher Named Millennium Pharmaceuticals Career Development Scholar of The Leukemia & Lymphoma Society
6. Childhood Leukemia Subtype Resists Treatment
7. Gene Governs Response to Leukemia Chemotherapy
8. Gene abnormality found to predict childhood leukemia relapse
9. The Leukemia & Lymphoma Society and The University of Kansas Cancer Center Announce Innovative Partnership to Accelerate Drug Development
10. Grape Seed Extract Kills Leukemia Cells in Lab
11. Stem cells and leukemia battle for marrow microenvironment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... Dallas, Texas (PRWEB) , ... June 24, 2016 ... ... 12th International Conference and Scientific Sessions in Dallas that it will receive two ... Announcement of the grants came as PHA marked its 25th anniversary by recognizing ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is ... Road To Recovery® program to drive cancer patients to and from their cancer treatments. ... the highest quality of life and ongoing independence. Getting to and from medical ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine ... Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor ... Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With this ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... actively feeding the Frederick area economy by obtaining investment capital for emerging technology ... past 2½ years that have already resulted in more than a million dollars ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... for human induced pluripotent stem (iPS) cells and other difficult to transfect cells, ... Cloning Medium. The PluriQ™ G9™ Gene Editing System is a complete ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 According ... by Type (Standard Pen Needles, Safety Pen Needles), Needle ... GLP-1, Growth Hormone), Mode of Purchase (Retail, Non-Retail) - ... This report studies the market for the forecast period ... reach USD 2.81 Billion by 2021 from USD 1.65 ...
(Date:6/23/2016)... June 23, 2016  MedSource announced today that ... e-clinical software solution of choice.  This latest decision ... value to their clients by offering a state-of-the-art ... relationship establishes nowEDC as the EDC platform of ... full-service clients.  "nowEDC has long been a preferred ...
(Date:6/23/2016)...  In a startling report released today, National Safety Council ... a comprehensive, proven plan to eliminate prescription opioid overdoses. ... states are tackling the worst drug crisis in recorded U.S. history, ... Kentucky , New Mexico , ... the 28 failing states, three – Michigan , ...
Breaking Medicine Technology: