Navigation Links
Leukemia stem cells have more in common with embryonic stem cells than adult stem cells
Date:2/5/2009

Research using a mouse model of human leukemia has provided critical insight into the genetic factors related to the generation and maintenance of myeloid leukemia stem cells. The study, published by Cell Press in the February 6th issue of the journal Cell Stem Cell, is likely to have a profound impact on the future design of therapeutic approaches targeted against cancer stem cells.

Leukemia stem cells (LSCs) were initially described as rare cells that share characteristics with normal hematopoietic stem cells (HSCs). HSCs are a type of partially committed adult stem cells that can give rise to multiple types of blood cells. However, recent research has demonstrated that LSCs can represent a significant fraction of leukemic cells and exhibit characteristics associated with more mature, differentiated myeloid cells rather than the more versatile HSCs.

"Since LSCs may be more numerous and mature than originally proposed, the nature and generality of the hierarchical organization of malignancies has recently been questioned," says senior study author Dr. Michael L. Cleary, from the Department of Pathology at Stanford University. Dr. Cleary and colleagues used a mouse model of human AML to investigate the genes that maintain LSC frequencies and leukemia cell hierarchies.

The researchers found that LSCs are maintained in a self-renewing state by subversion of a transcriptional program that shares features with pluripotent embryonic stem cells (ESCs). This transcriptional program is transiently expressed in normal myeloid precursor cells rather than HSCs or fully mature white blood cells. The authors go on to reveal a link between activation of genes associated with ESCs at an inappropriate stage of white blood cell development, the number of LSCs, and a poor prognosis in leukemia.

"Importantly, the shared transcriptional features of LSCs, ESCs, normal mid-myeloid lineage cells, and a diverse set of poor-prognosis human malignancies support the broader conclusion that cancer stem cells may be aberrantly self-renewing downstream progenitor cells," explains lead study author Dr. Tim Somervaille.

The study also highlights the potential of therapeutic strategies aimed at genes and pathways that are of greater importance to the function of LSCs than HSCs. "These findings may have a substantial clinical impact, as normal HSCs are necessary for regeneration of hematopoiesis following chemotherapy," offers Dr. Cleary.


'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Related medicine news :

1. St. Jude finds more than 100 gene variations linked with response to leukemia treatment
2. In Kids, Genes May Affect Leukemia Treatment
3. New study aims to reduce risk of childhood leukemia
4. Hard-to-Treat Leukemia Cell Subtype Identified
5. Dana-Farber Researcher Named Millennium Pharmaceuticals Career Development Scholar of The Leukemia & Lymphoma Society
6. Childhood Leukemia Subtype Resists Treatment
7. Gene Governs Response to Leukemia Chemotherapy
8. Gene abnormality found to predict childhood leukemia relapse
9. The Leukemia & Lymphoma Society and The University of Kansas Cancer Center Announce Innovative Partnership to Accelerate Drug Development
10. Grape Seed Extract Kills Leukemia Cells in Lab
11. Stem cells and leukemia battle for marrow microenvironment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... NY (PRWEB) , ... January 19, 2017 , ... ... of Clinical Conductor CTMS, which provides a modern CTMS workflow designed to seamlessly ... management information has been condensed to a single page, maximizing usability and improving ...
(Date:1/19/2017)... ... January 19, 2017 , ... Students interested in video can get a jump ... winner will earn a $1,000 scholarship and have his or her video posted on ... deadline is May 31, with the winner announced on June 9. , The competition ...
(Date:1/19/2017)... ... January 19, 2017 , ... Workrite Ergonomics announced this week ... Tranquility privacy panel system was designed to deliver the ideal blend of acoustic ... and provide the visual privacy required to maintain concentration levels and increase productivity. ...
(Date:1/19/2017)... , ... January 19, 2017 , ... Allegheny Health Network ... patients who seek access to the Network’s programs and services in the greater Pittsburgh ... specialty care appointments will be offered one for that same afternoon. , ...
(Date:1/19/2017)... ... January 19, 2017 , ... Rountree Brady Insurance Agency, a ... throughout eastern Georgia, is embarking on a charity effort to raise awareness and ... Americans every year than anything else, yet risk factors associated with heart disease ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... ViewRay, Inc. (Nasdaq: VRAY) announced today that the ... in Germany , has purchased a ... University Clinic Heidelberg as part of its initiative for ... will be headed by Medical Director and Professor Jürgen ... the German Cancer Research Center (DKFZ), the Heidelberg Heavy ...
(Date:1/19/2017)... , January 19, 2017 ... appears serious about reducing the FDA,s regulatory strictness ... in the medical drug industry, many of the ... new clinical trials and development of advanced drug ... ahead with recent developments include:  Moleculin Biotech, Inc., ...
(Date:1/19/2017)... ALAMEDA, Calif. , Jan. 18, 2017 /PRNewswire/ ... (MPI) solutions has entered into an agreement with ... for the Momentum MPI imaging system based on ... VivoQuant will be distributed as a complete MPI ... to enable quantitative nanoparticle or cell imaging in ...
Breaking Medicine Technology: