Navigation Links
Leukemia drug reverses tamoxifen-resistance in breast cancer cells
Date:8/1/2011

PHILADELPHIATaking a leukemia chemotherapy drug may help breast cancer patients who don't respond to tamoxifen overcome resistance to the widely-used drug, new research from the Kimmel Cancer Center at Jefferson suggests.

Interestingly, researchers found that taxoxifen combined with dasatinib, a protein-tyrosine kinase inhibitor, reverses the chemo-resistance caused by cancer-associated fibroblasts in the surrounding tissue by normalizing glucose intake and reducing mitochondrial oxidative stress, the process that fuels the cancer cells.

Previous animal studies have confirmed that combining tyrosine kinase inhibitors with anti-estrogen therapies, like tamoxifen, can prevent drug resistance, but none have suggested that the target of the inhibitors is the cancer-associated fibroblasts.

The researchers report their findings in the August 1 issue of Cell Cycle.

About 70 percent of women diagnosed with breast cancer will have estrogen receptor positive (ER(+)) disease, which indicates that the tumor may respond to tamoxifen. However, a large percentage of these tumorsup to 35 percenthave little to no response to the drug or eventually develop resistance to it.

In this study, researchers sought to better understand drug resistance by looking at the metabolic basis in an ER (+) cell line and cancer-associated fibroblasts. The researchers have previously established a relationship between the two, where cancer cells induce aerobic glycolysis by secreting hydrogen peroxide in adjacent fibroblasts via oxidative stress. In turn, these fibroblasts provide nutrients to the cancer cells to proliferate, a process that ultimately makes tumors grow.

Here, they investigated and then demonstrated that this interaction was also the basis of tamoxifen resistance.

In a sense, the drug combination had an "antioxidant effect" in these types of cancer cells, acco
'/>"/>

Contact: Steve Graff
stephen.graff@jefferson.edu
215-512-1783
Thomas Jefferson University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Bone marrow transplant survival more than doubles for young high-risk leukemia patients
2. Half-matched transplants widen pool of donors for leukemia and lymphoma
3. Toward a more efficient therapy for a specific form of leukemia
4. Multitasking meds: Scientists discover how drug for leukemia, psoriasis, may tackle vascular disease
5. Antibody-guided drug works against acute lymphoblastic leukemia
6. Ex-Dallas Maverick survives rare form of leukemia thanks to experimental drug treatment
7. UCSF team discovers key to fighting drug-resistant leukemia
8. Most Leukemia Patients Recover From Chemo Brain After Transplant: Study
9. Agent selectively targets malignant B cells in chronic leukemia, study shows
10. Possible new approach to treating deadly leukemia in babies
11. New drug shows potential for treatment-resistant leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Leukemia drug reverses tamoxifen-resistance in breast cancer cells
(Date:10/2/2014)... October 02, 2014 The Business ... 2014 BIG Awards for Business program. The BIG ... with a proprietary judging process scored by well-known ... globe. , “The winners this year epitomize what ... Managing Director of the Business Intelligence Group. “The ...
(Date:10/2/2014)... October 02, 2014 BamboofloorChina.com is a ... products have won great appreciation from the global customers ... working hard to make more excellent items. All its ... to help all clients. , The company has ... to its website. Furthermore, the company’s marketing specialist ...
(Date:10/2/2014)... Maureen Salamon HealthDay Reporter ... Middle-aged women with a neurotic personality style and prolonged ... disease, new research suggests. Tracking 800 women over ... were most anxious, jealous and moody -- which they ... double the risk of developing Alzheimer,s compared to women ...
(Date:10/2/2014)... Oct. 1, 2014 (HealthDay News) -- Genes may interact with ... study suggests. The genetic risk occurs in about 13 ... The finding could help these people reduce their heart disease ... diet and stress management, the Duke University researchers said. ... and found a strong link between variations in the EBF1 ...
(Date:10/2/2014)... HealthDay Reporter WEDNESDAY, Oct. ... highway may raise your risk for high blood pressure, a ... those who lived within 109 yards of a busy road ... pressure than women living at least half a mile away, ... the importance of our physical environment on our health and ...
Breaking Medicine News(10 mins):Health News:Innovation Dominant Theme among 2014 Big Awards for Business Winners and Finalists 2Health News:High Quality Bamboo Panels Online At BamboofloorChina.com 2Health News:Jealous, Moody Women May Face Higher Alzheimer's Risk, Study Says 2Health News:Jealous, Moody Women May Face Higher Alzheimer's Risk, Study Says 3Health News:Genes May Make Some More Prone to Heart Disease When Under Stress 2Health News:Living Near a Highway May Be Bad for Your Blood Pressure 2Health News:Living Near a Highway May Be Bad for Your Blood Pressure 3
... U.S. Senate to vote soon on legislation that ... Minnesota, WASHINGTON, July 9 Seniors across ... Medicare Advantage program in,legislation being considered in the ... million from the Medicare Advantage program in,Minnesota alone ...
... support medical care for the uninsured, human,services, and ... Blue Cross and Blue Shield,of Illinois (BCBSIL) ... in Illinois. In line with its mission, "to ... communities through accessible,cost-effective, quality health care," BCBSIL,s giving ...
... the University of Alabama at Birmingham (UAB) have been ... The project is a national consortium of cutting-edge hospitals ... for patients with a kind of malignant brain tumor ... consortium, UAB will serve as the only research site ...
... Fans Can ,Start Their Engines, and Nominate Now at ... ... trusted brands,for indigestion and heartburn relief, is launching a nationwide search for,one ... 500 Sprint,Cup Series race at Martinsville Speedway in Martinsville, Va. on October,19, ...
... Daniel Von Hoff, a member of President ... in-depth look at "The Complete Phase Ib," ... rapid accrual rates, substantial economies of scale, ... patients, and improved therapeutic benefits. The ...
... ARLINGTON, Va., July 9 The HealthCentral,Network, ... new online medical and peer-to-peer resource,committed to ... about,drugs, surgeries and nutrition, along with offering ... Three expert writers, University of Pennsylvania clinical ...
Cached Medicine News:Health News:Minnesota Seniors Speak Out Against Medicare Advantage Cuts 2Health News:Blue Cross and Blue Shield of Illinois Gives $960,000 in Charitable Donations 2Health News:Blue Cross and Blue Shield of Illinois Gives $960,000 in Charitable Donations 3Health News:UAB joins elite brain cancer research group 2Health News:TUMS Announces Nationwide Search for Grand Marshal at TUMS QuikPak 500 2Health News:Dr. Daniel Von Hoff Discusses "The Complete Phase Ib," A Clinical Trial Design Offering Faster Drug Development, Economies of Scale and Improved Therapeutic Benefit 2Health News:Dr. Daniel Von Hoff Discusses "The Complete Phase Ib," A Clinical Trial Design Offering Faster Drug Development, Economies of Scale and Improved Therapeutic Benefit 3Health News:Responding to Increased Incidence of Obesity and Associated Health Issues, The HealthCentral Network Launches Site to Support those Struggling with Weight 2
(Date:10/2/2014)... Mass. , Oct. 2, 2014  Alere Inc. (NYSE: ... announced today that the new E. HISTOLYTICA QUIK CHEK™ ... parasite, has received CE Mark for sale in international markets ... test is developed and manufactured by TECHLAB ® Inc. ... that infects an estimated 50 million people worldwide. Infected individuals ...
(Date:10/2/2014)... WOONSOCKET, R.I. , Oct. 2, 2014 ... Health Research Institute entitled, " Adherence: why it,s so ... reviews the Company,s key research findings on medication adherence ... five to 15 percent through new interventions by 2017. ... Institute has been focused on building the body of ...
(Date:10/2/2014)... , Oct. 2, 2014  MinuteClinic, the largest and fastest ... States , has opened its first walk-in clinics in the ... stores in Corpus Christi and ... Corpus Christi in December. The clinics are ... nationwide in 2014. With the Corpus Christi -area ...
Breaking Medicine Technology:Entamoeba histolytica Rapid Test Receives CE Mark 2CVS Health Insights Report Tackles Complex Issue of Medication Adherence 2CVS Health Insights Report Tackles Complex Issue of Medication Adherence 3First MinuteClinic Walk-in Medical Clinics Open in Corpus Christi 2First MinuteClinic Walk-in Medical Clinics Open in Corpus Christi 3
... Attorneys representing a group of U.S. citizens suffering from ... thalidomide have filed a lawsuit in federal court to compel ... drug was widely distributed in the United States. ... to a number of Freedom of Information Act (FOIA) requests ...
... of brand drug "copay coupon" promotions, which lure insured ... costs by $1.8 billion in Pennsylvania over the next ... to new research from Visante and released by the ... of these promotions by state and local government workers ...
Cached Medicine Technology:Hagens Berman: Patients Seek to Force FDA to Release Records Showing US Distribution of Thalidomide 2Hagens Berman: Patients Seek to Force FDA to Release Records Showing US Distribution of Thalidomide 3Brand Drug 'Copay Coupons' Undermine Generics, Raise Health Costs by $1.8 Billion in Pennsylvania 2
This double-up gel dryer system, 100-120 V, includes 2 Model 583 gel dryers, HydroTech™ vacuum pump, and double-up rack....
... GelAir™ drying system utilizes a hot air drying ... dried on a clear cellophane support for easy ... a smooth, flat assembly surface for the drying ... frames at once. This 115 V, 60 Hz ...
... dryer is an electrophoresis gel vacuum dryer that ... dries these gels onto cellophane or filter paper ... elements which heat gels from above. The drying ... V unit includes power cord, porous gel support, ...
... The PRO6000 power supply ... Thermo's power supply product offering. ... proteomic and genomic electrophoresis. This ... to proteomic applications such as ...
Medicine Products: