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Leukemia cells evade immune system by mimicking normal cells, Stanford studies show
Date:7/23/2009

er avenues remain to be explored, say the researchers. For instance, Majeti and Chao showed that it is possible to separate leukemia stem cells from an individual patient into high and low CD47 groups. They found that the low-CD47 group contained normal blood stem cell progenitors.

"We've never before had the capability of reliably separating cancer cells from normal blood stem cells for bone marrow transplantation," said Majeti, who pointed out that the normal stem cells could be used to rescue a patient whose immune system had been destroyed with lethal doses of cancer-killing radiation. If possible, this approach could theoretically eliminate the need for a matched donor by relying on the patient's own cells. "It's a dream come true for me as a physician-scientist to be researching something that is so applicable to patients," said Majeti.


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Contact: Ruthann Richter
richter1@stanford.edu
650-725-8047
Stanford University Medical Center
Source:Eurekalert

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