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Leukemia Patients Get Treatment Boost From Donors' Immune Cells
Date:2/27/2013

, "This is telling us that we can create an immunotherapy that recognizes a protein [WT1] that's associated with why a cell is cancerous. This really is opening up a very large window of immunotherapies targeting these cancer-associated proteins . . . [We can] start using immune cells to ferret out cells overexpressing that protein and use that as their Achilles' heel."

The study was also significant in that the researchers were able to guide these cells to recognize a specific target and reproduce them in the billions outside of the body, said Dr. Ryotaro Nakamura, associate professor of hematology and hematopoietic stem cell transplantation at City of Hope in Duarte, Calif.

It's unclear how the results will apply in a larger population, but the technique used was "remarkable," Nakamura said.

More information

There's more on leukemia at the U.S. National Cancer Institute.

SOURCES: David Wiest, Ph.D., deputy science director, Fox Chase Cancer Center, Philadelphia; Aude Chapuis, M.D., research associate, Fred Hutchinson Cancer Research Center and acting instructor, University of Washington Medical Center, Seattle; Philip D. Greenberg, M.D., professor of medicine and immunology, University of Washington and head, Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle; Ryotaro Nakamura, M.D., associate professor of hematology and hematopoietic stem cell transplantation, City of Hope, Duarte, Calif.; Feb. 27, 2013, Science Translational Medicine


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