Navigation Links
Leukaemia cells have a remembrance of things past
Date:4/24/2012

Although people generally talk about "cancer", it is clear that the disease occurs in a bewildering variety of forms. Even single groups of cancers, such as those of the white blood cells, may show widely differing properties. How do the various cancers arise and what factors determine their progression? Clues to these two issues, at least for leukaemias, have now been provided by Boris Kovacic and colleagues at the University of Veterinary Medicine, Vienna (Vetmeduni Vienna). The results are published in the current issue of the journal EMBO Molecular Medicine and have extremely important consequences for the treatment of a particularly aggressive type of leukaemia.

It is well known that many types of cancer arise as a result of a mutation within a cell and prevailing wisdom has held that the stage of differentiation of this cell determines exactly what form of cancer develops. For example, it was believed that so-called chronic myeloid leukaemia or CML arises from bone marrow stem cells, while a different type of leukaemia, known as B-cell acute lymphoid leukaemia or B-ALL, results from B-cell precursors. This belief has been spectacularly refuted by the latest results from Boris Kovacic and colleagues in the Vetmeduni Vienna's institutes of Animal Breeding and Genetics and of Pharmacology and Toxicology.

The researchers have now shown that both CML and B-ALL arise from the most primordial kind of blood cell (long-term haematopoietic stem cells), although the pathways by which the diseases progress are different. The usual causes of CML and B-ALL are two highly related versions of the same oncogene, BCR/ABL. If the primordial blood cells are transformed or made potentially cancerous by a particular version of BCR/ABL, for technical reasons termed BCR/ABLp210, the result is chronic myeloid leukaemia or CML. The long-term haematopoietic stem cells remain and act as the dreaded cancer stem cells, or CSCs, which ensure that the
'/>"/>

Contact: Dr Boris Kovacic
Boris.Kovacic@vetmeduni.ac.at
43-125-077-5622
University of Veterinary Medicine -- Vienna
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New study reveals more people surviving leukaemia and pancreatic cancer in Northern Ireland
2. IBN discovers human neural stem cells with tumor targeting ability
3. Therapy exploits addiction of leukemia cells
4. Scientists identify major source of cells defense against oxidative stress
5. To prevent leukemias dreaded return, go for the stem cells
6. Tiny hitchhikers attack cancer cells
7. New drug prevents spread of human prostate cancer cells
8. A*STAR scientists discover special class of natural fats stimulates immune cells to fight diseases
9. Newly identified stem cells may hold clues to colon cancer
10. Biologists uncover surprising connection between breast cancer cells and surrounding tissue
11. How cancer cells start new tumor sites
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Presently, disposable medical suppliers call for the ... segment. During the past two decades, the world market ... average 12.5% per year), primarily owing to the importance ... is the largest market for disposable medical supplies in ... second position is held by Europe with a 29% ...
(Date:7/11/2014)... July 11, 2014 The Corn ... years to 2014 on the heels of fresh biofuel ... farmers to dedicate a larger share of their farmland ... specifically, the regulations required the mixing of 5.0% renewable ... production in the United States created a key export ...
(Date:7/11/2014)... Ticket Down is a reliable source ... Amphitheatre in Wheatland, CA. In the Sacramento California ... the Sleep Train Amphitheatre can do for music fans. The ... the course of its existence and can seat 18,500 fans ... Wheatland (Sacramento metro area) will host the “That’s My Kind ...
(Date:7/11/2014)... Pigments are insoluble colorants, which usually consist of ... coating, opacity, and coloring. These are water and oil ... substances such as paper, paints, plastics, and concrete. Binders ... impart color to the substance. Some examples of pigments ... , The coloring action of pigments is due to ...
(Date:7/11/2014)... York, NY (PRWEB) July 11, 2014 ... dramatic increase in men seeking cosmetic surgery and hair ... year. With such an expansive range of medical tourism ... exceptional plastic surgery costs and achieve the ... to be renowned as the top name in the ...
Breaking Medicine News(10 mins):Health News:Global Disposable Medical Supplies Market to See Robust Growth Through Next Decade, According to New TriMark Report Available at MarketPublishers.com 2Health News:Global Disposable Medical Supplies Market to See Robust Growth Through Next Decade, According to New TriMark Report Available at MarketPublishers.com 3Health News:Corn Farming in Canada Industry Market Research Report Now Available From IBISWorld 2Health News:Corn Farming in Canada Industry Market Research Report Now Available From IBISWorld 3Health News:Luke Bryan Tickets Sleep Train Amphitheatre in Wheatland, CA (Sacramento): Ticket Down has Slashed Ticket Prices on Luke Bryan in Wheatland at Sleep Train 2Health News:Luke Bryan Tickets Sleep Train Amphitheatre in Wheatland, CA (Sacramento): Ticket Down has Slashed Ticket Prices on Luke Bryan in Wheatland at Sleep Train 3Health News:Americas Pigments Market Worth 1,099 Thousand MT by 2018 - New Report by MicroMarket Monitor 2Health News:Americas Pigments Market Worth 1,099 Thousand MT by 2018 - New Report by MicroMarket Monitor 3Health News:VisitandCare.com Reports Increase in Cosmetic and Hair Transplant Procedures for Men 2Health News:VisitandCare.com Reports Increase in Cosmetic and Hair Transplant Procedures for Men 3
... a 47-year-old man who had worked for a Hindustan Lever ... who had also been exposed to toxic mercury, to the ... than 500 protestors, who said he had been slowly poisoned ... an autopsy to assess the possibility of mercury-induced damage. ...
... new study examined the connection between Baltimore City’s needle ... ,Individuals who enter treatment programs for drug addiction were ... Baltimore City needle exchange programs. ,The ... of Public Health highlights the need for treatment facilities ...
... always the result of a subtle marriage between a ... an appropriate excipient// (a neutral substance in which the ... absorbed by the body). Thus the necessary tablet, capsule ... biodegradable materials were used instead of these neutral excipients? ...
... multiple positive social outcomes,// research conducted in rural ... of the Journal of Acquired Immune Deficiency Syndromes ... appear to lead to stigmatisation or an increase ... increase in the incidence of domestic violence against ...
... transition service has been instituted by the NHS trust to ... ,‘Minding the Gap’, a document enabled by ... regular service for 16- to 18-year-olds, in Durham and Darlington. ... out to the teenagers suffering health problems across six primary ...
... Complementary //and Alternative Medicine (NCCAM) at the National Institutes ... better, especially about alternative therapies they are trying out ... ,This is the outcome of a survey conducted ... 1600 patients, and their doctors. ,It ...
Cached Medicine News:Health News:Ex-workers Ask HLL to Accept Liability for Mercury Deaths 2Health News:Drug Treatment Seekers Likely to Use Needle Exchange 2Health News:New Generation - Medicinal Products 2Health News:New Generation - Medicinal Products 3Health News:HIV Home-based Care Produces Positive Outcomes in Uganda 2Health News:HIV Home-based Care Produces Positive Outcomes in Uganda 3Health News:Elderly Patients Usually Keep Mum About Use of Alternative Medicine , Reveals Survey 2
(Date:7/10/2014)... U.S. Department of Health and Human Services (HHS) has ... Medical Center Seidman Cancer Center totaling $4.7 million to ... for patients with complex cancer. Titled ... model developed at UH to enhance care for adult ... need for high health care utilization.  ...
(Date:7/10/2014)... DIEGO , July 10, 2014  RESMED INC. (NYSE: ... its fourth quarter and fiscal year ended June 30, 2014 ... Stock Exchange market close. A press release with ResMed,s results ... the company will host a webcast to discuss operating results ... to begin at 1:30 p.m. US Pacific Time and the ...
(Date:7/10/2014)... -- Valeant Pharmaceuticals International, Inc. (NYSE: VRX ... sale to Galderma of all rights to Restylane, Perlane, ... for $1.4 billion in cash, pursuant to the previously ... acquisition of Galderma. "We are pleased ... company that is firmly committed to the aesthetic dermatology ...
Breaking Medicine Technology:University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 3University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 4ResMed To Announce Fourth Quarter And Fiscal Year-End 2014 Results 2
... 30, 2011 David N. Jonas, CEO, PharMEDium ... investments for innovations with an unprecedented focus on ... with a steady stream of technologically-driven service advancements.  Working ... safety and quality , PharMEDium ...
... 30, 2011 Reportlinker.com announces that a new ... catalogue: Pharmaceutical Distributors - ... This register contains information ... Europe. The register includes the following information ...
Cached Medicine Technology:PharMEDium's Technology Helps Hospital Pharmacists Ensure Safety 2
... Instrument program offers state-of-the-art quality in an ... strength and durability. Low profile cutting tips ... spaces. Series I instruments are available in ... and angle required for large and small ...
... program offers state-of-the-art quality in an instrument ... and durability. Low profile cutting tips allow ... Series I instruments are available in just ... angle required for large and small joint ...
... The WideBiter Punch series facilitates fast ... recreating a smooth, anatomically shaped meniscal rim. ... low profile to access even the tightest ... Arthrex California, Inc., 20 years of engineering ...
... The WideBiter Punch series facilitates fast and ... a smooth, anatomically shaped meniscal rim. The ... profile to access even the tightest joint ... California, Inc., 20 years of engineering experience ...
Medicine Products: