Navigation Links
Less Sensitivity to Hormone May Play Role in Autism
Date:10/21/2009

Treatment with oxytocin might improve social interaction, researchers say

WEDNESDAY, Oct. 21 (HealthDay News) -- A new genetic signature that's strongly associated with autism has been identified by U.S. researchers, who said the finding may lead to new ways to diagnose and treat the disorder.

This genetic signature doesn't involve changes to DNA sequence itself, but rather to the way that genes are switched on and off, said the team from Duke University Medical Center in Durham, N.C. They found that people with autism have a higher-than-normal number of gene-regulating molecules called methyl groups in a region of the genome that regulates oxytocin receptor expression.

"In both blood samples and brain tissue, the methylation status of specific nucleotides in the oxytocin receptor gene is significantly higher in someone with autism, about 70 percent, compared to the control population, where it is about 40 percent," study co-lead author Simon G. Gregory, an assistant professor in the Duke department of medicine, said in a university news release.

Oxytocin is a hormone that affects social interaction. Previous research found that giving oxytocin to people with autism can improve their ability to socialize. The hormone is being investigated as a possible treatment for autism, the study authors noted.

In their report, published in the Oct. 21 online edition of the journal BMC Medicine, the researchers noted that higher methylation of the oxytocin receptor gene may result in less sensitivity to the hormone. The authors suggested that their research may lead to ways to identify people who will respond better to treatment with oxytocin.

"We are excited about our findings because they represent one of the few occasions in which a mechanism other than genetic susceptibility or genome instability is implicated in the development of autism," Gregory explained in the news release.

"These results provide a possible explanation of why social isolation forms part of the autism spectrum -- because an autistic individual's ability to respond to oxytocin may be limited. Oxytocin has been tied to levels of trust and ability to read social cues," Gregory added.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about autism.



-- Robert Preidt



SOURCE: Duke University, news release, Oct. 21, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Scientists explain how insulin secreting cells maintain their glucose sensitivity
2. Sensitivity of brain center for sound space defined
3. Study questions assumptions about human sensitivity to biological motion
4. Cocaine Use Dulls Brains Sensitivity to Rewards
5. Test Detects Sensitivity to HIV Drug
6. Routinely used diagnostic approaches: only limited diagnostic sensitivity for bile duct cancer?
7. Karmanos Researchers Report Enhanced Chemosensitivity of Pancreatic Cancer Cells by Black Seed Component
8. Skin Pain, Sensitivity Rises With Migraine
9. Study shows that administering calcium and magnesium effectively reduces neurological sensitivity
10. Monogram Biosciences Announces Immediate Availability of Enhanced Sensitivity Trofile(TM) HIV Tropism Assay
11. Eleven Going on 70: SCAN Health Plan Helps Fifth Graders Understand Aging Through First-Ever Senior Sensitivity Training for Kids
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... Las Vegas, NV (PRWEB) , ... May 26, 2016 , ... ... of Ergonomic Tools,” identifies the impact of mobile devices on the billions of users, ... upper backs and necks. While not life threatening, the frequent and common action ...
(Date:5/26/2016)... , ... May 26, 2016 , ... In Madeira Beach ... mainland by a single drawbridge, citizens formed an organization, Madeira Beach United, to oppose ... and change the small town center to a high rise urban environment. , According ...
(Date:5/26/2016)... ... 26, 2016 , ... HealthPostures, ergonomics designer and maker of the bestselling TaskMate ... women during pregnancy. Potential benefits of using the Stance Angle chair include the prevention ... levels of sitting and standing. , Need for the ergonomics furniture may be growing, ...
(Date:5/25/2016)... (PRWEB) , ... May 25, ... ... received the American Heart Association/American Stroke Association's Get With The Guidelines®-Stroke Gold ... , This achievement, a second for Memorial Healthcare System, recognizes its commitment ...
(Date:5/25/2016)... ... May 25, 2016 , ... Serenity ... produced another video highlighting one of the many supplemental program options offered at ... Taylor, a 5 th Degree Black Belt in the Shorin-ryu style of Karate ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... , May 24, 2016 ... Education in Clinical Neurophysiology  Elsevier , ... products and services, today announced the launch of ... open access journal that focuses on clinical practice issues ... case reports, clinical series, normal values and didactic reviews. ...
(Date:5/23/2016)... According to a new ... Product (Wheelchair, Scooters, Medical Beds, Bathroom Safety, Mechanical, ... Wound), Accessories (Lifting, Transfer) & by End User ... MarketsandMarkets, the patient handling equipment market is expected ... a CAGR of 10.5% during the forecast period ...
(Date:5/23/2016)... York , May 23, 2016 ... report titled, " Exocrine Pancreatic Insufficiency Market - Global ... - 2023 ." According to the report, the exocrine ... CAGR of 8.3% from 2015 to 2023 to reach ... (EPI) is a condition characterized by the deficiency of ...
Breaking Medicine Technology: