Navigation Links
Less Sensitivity to Hormone May Play Role in Autism
Date:10/21/2009

Treatment with oxytocin might improve social interaction, researchers say

WEDNESDAY, Oct. 21 (HealthDay News) -- A new genetic signature that's strongly associated with autism has been identified by U.S. researchers, who said the finding may lead to new ways to diagnose and treat the disorder.

This genetic signature doesn't involve changes to DNA sequence itself, but rather to the way that genes are switched on and off, said the team from Duke University Medical Center in Durham, N.C. They found that people with autism have a higher-than-normal number of gene-regulating molecules called methyl groups in a region of the genome that regulates oxytocin receptor expression.

"In both blood samples and brain tissue, the methylation status of specific nucleotides in the oxytocin receptor gene is significantly higher in someone with autism, about 70 percent, compared to the control population, where it is about 40 percent," study co-lead author Simon G. Gregory, an assistant professor in the Duke department of medicine, said in a university news release.

Oxytocin is a hormone that affects social interaction. Previous research found that giving oxytocin to people with autism can improve their ability to socialize. The hormone is being investigated as a possible treatment for autism, the study authors noted.

In their report, published in the Oct. 21 online edition of the journal BMC Medicine, the researchers noted that higher methylation of the oxytocin receptor gene may result in less sensitivity to the hormone. The authors suggested that their research may lead to ways to identify people who will respond better to treatment with oxytocin.

"We are excited about our findings because they represent one of the few occasions in which a mechanism other than genetic susceptibility or genome instability is implicated in the development of autism," Gregory explained in the news release.

"These results provide a possible explanation of why social isolation forms part of the autism spectrum -- because an autistic individual's ability to respond to oxytocin may be limited. Oxytocin has been tied to levels of trust and ability to read social cues," Gregory added.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about autism.



-- Robert Preidt



SOURCE: Duke University, news release, Oct. 21, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Scientists explain how insulin secreting cells maintain their glucose sensitivity
2. Sensitivity of brain center for sound space defined
3. Study questions assumptions about human sensitivity to biological motion
4. Cocaine Use Dulls Brains Sensitivity to Rewards
5. Test Detects Sensitivity to HIV Drug
6. Routinely used diagnostic approaches: only limited diagnostic sensitivity for bile duct cancer?
7. Karmanos Researchers Report Enhanced Chemosensitivity of Pancreatic Cancer Cells by Black Seed Component
8. Skin Pain, Sensitivity Rises With Migraine
9. Study shows that administering calcium and magnesium effectively reduces neurological sensitivity
10. Monogram Biosciences Announces Immediate Availability of Enhanced Sensitivity Trofile(TM) HIV Tropism Assay
11. Eleven Going on 70: SCAN Health Plan Helps Fifth Graders Understand Aging Through First-Ever Senior Sensitivity Training for Kids
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, ... Development, has been awarded a contract by the Center for Medicare and Medicaid ... to accelerate the enterprise use of Agile methodologies in a consistent and high ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and ... of published author, William Nowers. Captain Nowers and his wife, Millie, have six ... years in the Navy. Following his career as a naval aviator and carrier ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... are now treating sleep apnea using cutting-edge Oventus O2Vent technology. As ... serious sleep disorder characterized by frequent cessation in breathing. Oral appliances can offer ...
(Date:10/12/2017)... ... October 12, 2017 , ... The ... demand of today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, ... to meet the highest standard. , These products are also: Gluten Free, ...
(Date:10/12/2017)... ... ... The American College of Medical Informatics (ACMI) will present the 2017 Morris F. ... AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is taking place ... the field of medical informatics, this prestigious award is presented to an individual whose ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... and Consulting, LLC , and named its founder as ... in Tennessee , will operate under ... EnvoyHealth,s service offerings for health care partners to include ... "In an interoperable world, technology delivers ...
(Date:10/2/2017)... 2, 2017 Halo Labs announces the European launch of ... the HORIZON at MIBio 2017 in Cambridge, U.K ... particulate matter in biopharmaceutical samples with unprecedented speed and sensitivity while ... technique Backgrounded Membrane Imaging. ... HORIZON subvisible particle analysis system ...
(Date:9/28/2017)... 2017 Cohen Veterans Bioscience and Early Signal ... wearable and home sensors for real-time monitoring of patients ... a nonprofit organization focused on disruptive health solutions for ... analytical system to record and integrate behavioral, cognitive, physiological ... ...
Breaking Medicine Technology: