Navigation Links
Less Invasive Heart Valve Replacement Works for Elderly: Study
Date:5/2/2012

By Steven Reinberg
HealthDay Reporter

WEDNESDAY, May 2 (HealthDay News) -- For elderly patients with a heart valve disease known as aortic stenosis, a procedure called a transcatheter aortic-valve implantation appears safe and effective, French researchers say.

Transcatheter aortic-valve implantation is a less invasive way of replacing the heart's aortic valve than traditional open-heart surgery. The procedure involves passing a replacement valve through a leg or shoulder artery and advancing it until it reaches the aortic valve, taking its place. The U.S. Food and Drug Administration approved the technique in 2011.

"Surgical aortic valve replacement is the definitive therapy for severe symptomatic aortic stenosis," said study co-author Dr. Martine Gilard, of the department of cardiology at Brest University Hospital in France. And transcatheter aortic-valve implantation "is a new therapeutic option for these patients," he said.

The U.S. Centers for Medicare and Medicaid Services said Monday it would cover the cost of the implantation, provided it is conducted by experienced surgeons in hospitals approved to perform the procedure. The agency estimates that 30 percent of Americans age 65 and older have aortic valve stenosis, the most common heart valve disease, or a related condition.

In aortic stenosis, the aortic valve doesn't open all the way, which reduces blood flow from the heart to the rest of the body. Severe forms can cause light-headedness and fainting.

For the study, which is scheduled to be published in the May 3 issue of the New England Journal of Medicine, the researchers evaluated data from a national registry of more than 3,100 French patients, with an average age of 82, who underwent the less invasive procedure from January 2010 to October 2011.

All the patients showed symptoms of aortic stenosis, and were considered at high risk for valve-replacement surgery.

The procedure was considered successful for almost 97 percent of the patients. Nearly 10 percent died within a month after the procedure, and 24 percent died within a year. The risk of death within a year without a valve replacement, however, is about 50 percent, the researchers noted.

The researchers also found that within one year, 4 percent of the patients suffered a stroke, and the new valve leaked in almost 65 percent of cases.

The sickest patients -- those with leaky valves and those who had the valve replaced through an artery near the collarbone -- were at greatest risk of dying, the researchers found.

About 16 percent of the patients needed a permanent pacemaker after the procedure. Although the authors acknowledged that information on complications was limited, they said the complication rate seemed acceptable given the high prevalence of coexisting illnesses.

The study was funded by Edwards Lifesciences and Medtronic, makers of the replacement valves used in the study.

Lead researcher Dr. Marc Laskar, of the department of thoracic, cardiovascular and vascular surgery at the University of Limoges and Dupuytren University Hospital in France, said the main question now is whether the procedure can be used for low-risk patients or younger patients.

To answer that question, researchers have to know the long-term results and the durability of the valve in real life, Laskar said.

"[Transcatheter aortic-valve implantation] has been demonstrated in randomized clinical trials to improve survival in patients with severe aortic stenosis who are not candidates for surgical aortic valve replacement and produce comparable outcomes to surgery in patients who are at high risk," said Dr. Gregg Fonarow, a professor of cardiology at the University of California, Los Angeles. Fonarow was not involved in the study.

Understanding outcomes in real-world patients treated with transcatheter aortic-valve implantation is important because these patients, their physicians and hospitals can differ from those in clinical trials, Fonarow said.

This new real-world study provides valuable data on the outcome of transcatheter aortic-valve implantation.

"Prospective data such as these provide valuable insights into the implementation of novel interventional treatments into real-life clinical practice," Fonarow said.

More information

For more information on heart valve replacement, visit the American Heart Association.

SOURCES: Marc Laskar, M.D., thoracic and cardiovascular and vascular surgery department, University of Limoges, Limoges, France; Martine Gilard, M.D., Ph.D., department of cardiology, Brest University Hospital, Brest, France; Gregg Fonarow, M.D., professor of cardiology, University of California, Los Angeles; May 3, 2012, New England Journal of Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Less-Invasive Surgery for Esophageal Cancer Might Be Safer
2. Lower Risk for Bowel Obstruction With Less Invasive Surgery: Study
3. Invasive heart test being dramatically overused, Stanford study shows
4. Routine mammograms may result in significant overdiagnosis of invasive breast cancer
5. Researchers identify mechanism that makes breast cancer invasive
6. Less Invasive Hernia Procedure Easier on Patients: Study
7. Mayo Clinic: Robotic surgery proves successful, less invasive way to treat HPV-related oral cancer
8. CD97 gene expression and function correlate with WT1 protein expression and glioma invasiveness
9. ACCF/AATS/SCAI/STS release consensus document to help guide use of minimally invasive heart therapy
10. Researchers find new, noninvasive way to identify lymph node metastasis
11. Researchers describe a new genetic program that converts static cells into mobile invasive cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Less Invasive Heart Valve Replacement Works for Elderly: Study
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery ... of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , ... for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as ... City area —Johnson is one of the first doctors to perform the treatment. ...
(Date:6/24/2016)... , ... June 24, 2016 , ... June 19, 2016 ... dangers associated with chronic pain and the benefits of holistic treatments, Serenity Recovery ... are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA ... the Road To Recovery® program to drive cancer patients to and from their cancer ... ensure the highest quality of life and ongoing independence. Getting to and from ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® ... Group (TGIG), has initiated cultivation and processing operations at its production facility, and ... Nevada. , Puradigm is the manufacturer of a complete system of proactive air ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Research and Markets has announced the addition ... 2022" report to their offering. ... with kidney failure, it replaces the function of kidneys by ... and thus the treatment helps to keep the patient body,s ... Increasing number of ESRD patients & substantial healthcare ...
(Date:6/23/2016)... 2016  In a startling report released today, National Safety ... lacking a comprehensive, proven plan to eliminate prescription opioid overdoses. ... how states are tackling the worst drug crisis in recorded U.S. ... Kentucky , New Mexico , ... Of the 28 failing states, three – Michigan ...
(Date:6/23/2016)... June 23, 2016 Capricor ... ), a biotechnology company focused on the discovery, ... that patient enrollment in its ongoing randomized HOPE-Duchenne ... exceeded 50% of its 24-patient target. Capricor expects ... third quarter of 2016, and to report top ...
Breaking Medicine Technology: