Navigation Links
Less Invasive Heart Valve Replacement Works for Elderly: Study
Date:5/2/2012

By Steven Reinberg
HealthDay Reporter

WEDNESDAY, May 2 (HealthDay News) -- For elderly patients with a heart valve disease known as aortic stenosis, a procedure called a transcatheter aortic-valve implantation appears safe and effective, French researchers say.

Transcatheter aortic-valve implantation is a less invasive way of replacing the heart's aortic valve than traditional open-heart surgery. The procedure involves passing a replacement valve through a leg or shoulder artery and advancing it until it reaches the aortic valve, taking its place. The U.S. Food and Drug Administration approved the technique in 2011.

"Surgical aortic valve replacement is the definitive therapy for severe symptomatic aortic stenosis," said study co-author Dr. Martine Gilard, of the department of cardiology at Brest University Hospital in France. And transcatheter aortic-valve implantation "is a new therapeutic option for these patients," he said.

The U.S. Centers for Medicare and Medicaid Services said Monday it would cover the cost of the implantation, provided it is conducted by experienced surgeons in hospitals approved to perform the procedure. The agency estimates that 30 percent of Americans age 65 and older have aortic valve stenosis, the most common heart valve disease, or a related condition.

In aortic stenosis, the aortic valve doesn't open all the way, which reduces blood flow from the heart to the rest of the body. Severe forms can cause light-headedness and fainting.

For the study, which is scheduled to be published in the May 3 issue of the New England Journal of Medicine, the researchers evaluated data from a national registry of more than 3,100 French patients, with an average age of 82, who underwent the less invasive procedure from January 2010 to October 2011.

All the patients showed symptoms of aortic stenosis, and were considered at high risk for valve-replacement surgery.

The procedure was considered successful for almost 97 percent of the patients. Nearly 10 percent died within a month after the procedure, and 24 percent died within a year. The risk of death within a year without a valve replacement, however, is about 50 percent, the researchers noted.

The researchers also found that within one year, 4 percent of the patients suffered a stroke, and the new valve leaked in almost 65 percent of cases.

The sickest patients -- those with leaky valves and those who had the valve replaced through an artery near the collarbone -- were at greatest risk of dying, the researchers found.

About 16 percent of the patients needed a permanent pacemaker after the procedure. Although the authors acknowledged that information on complications was limited, they said the complication rate seemed acceptable given the high prevalence of coexisting illnesses.

The study was funded by Edwards Lifesciences and Medtronic, makers of the replacement valves used in the study.

Lead researcher Dr. Marc Laskar, of the department of thoracic, cardiovascular and vascular surgery at the University of Limoges and Dupuytren University Hospital in France, said the main question now is whether the procedure can be used for low-risk patients or younger patients.

To answer that question, researchers have to know the long-term results and the durability of the valve in real life, Laskar said.

"[Transcatheter aortic-valve implantation] has been demonstrated in randomized clinical trials to improve survival in patients with severe aortic stenosis who are not candidates for surgical aortic valve replacement and produce comparable outcomes to surgery in patients who are at high risk," said Dr. Gregg Fonarow, a professor of cardiology at the University of California, Los Angeles. Fonarow was not involved in the study.

Understanding outcomes in real-world patients treated with transcatheter aortic-valve implantation is important because these patients, their physicians and hospitals can differ from those in clinical trials, Fonarow said.

This new real-world study provides valuable data on the outcome of transcatheter aortic-valve implantation.

"Prospective data such as these provide valuable insights into the implementation of novel interventional treatments into real-life clinical practice," Fonarow said.

More information

For more information on heart valve replacement, visit the American Heart Association.

SOURCES: Marc Laskar, M.D., thoracic and cardiovascular and vascular surgery department, University of Limoges, Limoges, France; Martine Gilard, M.D., Ph.D., department of cardiology, Brest University Hospital, Brest, France; Gregg Fonarow, M.D., professor of cardiology, University of California, Los Angeles; May 3, 2012, New England Journal of Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Less-Invasive Surgery for Esophageal Cancer Might Be Safer
2. Lower Risk for Bowel Obstruction With Less Invasive Surgery: Study
3. Invasive heart test being dramatically overused, Stanford study shows
4. Routine mammograms may result in significant overdiagnosis of invasive breast cancer
5. Researchers identify mechanism that makes breast cancer invasive
6. Less Invasive Hernia Procedure Easier on Patients: Study
7. Mayo Clinic: Robotic surgery proves successful, less invasive way to treat HPV-related oral cancer
8. CD97 gene expression and function correlate with WT1 protein expression and glioma invasiveness
9. ACCF/AATS/SCAI/STS release consensus document to help guide use of minimally invasive heart therapy
10. Researchers find new, noninvasive way to identify lymph node metastasis
11. Researchers describe a new genetic program that converts static cells into mobile invasive cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Less Invasive Heart Valve Replacement Works for Elderly: Study
(Date:8/22/2017)... ... August 22, 2017 , ... Although Labor Day is ... many communities have begun providing weekend displays, and numerous households celebrate the unofficial end ... can be downright terrifying for pets. , Kris Zambo, owner of Dynamite ...
(Date:8/21/2017)... ... August 22, 2017 , ... Nanoparticle research provides ... and safety. By learning and implementing best practices for containment using ventilated safety ... attendees will gain a better understanding of a method for safely testing nanotechnology ...
(Date:8/21/2017)... ... August 21, 2017 , ... Los Angeles area medical group ... academic year 2017-2018, Christina M. Busuito, M.D. and Lukasz Swistun, M.D. This one ... and Reconstructive Surgery. The candidate will have the opportunity to work with ...
(Date:8/21/2017)... ... August 21, 2017 , ... SportsEngine, Inc. , a ... Technology Partner of North Country Region Volleyball and will power registration, scheduling, and ... with providing sport management software to their member clubs. , SportsEngine ...
(Date:8/21/2017)... ... August 21, 2017 , ... ... place all over the country. , Outdoor running increases exposure to ultraviolet radiation, ... an increased risk of melanoma, and only half may be adequately protecting themselves ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... Inc. announced today that its fully owned USA ... York City Office in Yonkers, New York ... (TWO 2 ) homecare therapy. This new East Coast location has ... under the company,s DMEPOS accreditation for Home/Durable Medical Equipment Services. ... Advanced Oxygen Therapy Inc. New ...
(Date:8/8/2017)... Ltd. (NASDAQ/TASE: BLRX), a clinical-stage biopharmaceutical company focused on ... the second quarter ended June 30, 2017. ... to date: Continued ... lead project, BL-8040: Announced plans to ... stem cell mobilization treatment for autologous bone-marrow transplantation in ...
(Date:8/7/2017)... Diplomat Pharmacy, Inc. (NYSE: DPLO ) ... president, effective Aug. 7, 2017. ... other interests and will serve as president emeritus during a ... us in multiple leadership roles since he joined Diplomat with ... has provided decisive, strategic leadership which continues to benefit our ...
Breaking Medicine Technology: