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Lengthening dosing schedule of HPV vaccine may provide effective option for expanding use of vaccine
Date:4/12/2011

Administration of human papillomavirus (HPV) vaccine doses over a longer period of time to adolescent girls in Vietnam resulted in antibody concentration levels that were comparable to the standard vaccine schedule, according to a study in the April 13 issue of JAMA, a theme issue on infectious disease and immunology.

Kathleen M. Neuzil, M.D., M.P.H., of PATH, Seattle, presented the findings of the study at a JAMA media briefing at the National Press Club in Washington, D.C.

Cervical cancer is an important cause of illness and death among women throughout the world. "Each year, new cases of cervical cancer occur in approximately 529,000 women and 275,000 women die. An estimated 88 percent of deaths due to cervical cancer occur among women residing in developing countries," according to background information in the article. Human papillomaviruses are the primary cause of cervical cancer. "Combined with continued strengthening of simple evidence-based screening and treatment approaches, effective HPV vaccine programs could reduce cervical cancer rates in developing countries to the low levels currently observed in many developed countries. One challenge to broadly implementing HPV vaccination programs in developing countries will be delivering the currently recommended 3 doses of vaccine to adolescents within 6 months (dosing schedules at 0, 2, and 6 months or at 0, 1, and 6 months)," the authors write. Even in settings in which such vaccination schedules are feasible, alternative schedules may have advantages, such as lower cost (the vaccine could be delivered with other health interventions) or increased coverage (it may be easier for girls and their families or for vaccinators).

Dr. Neuzil and colleagues conducted a randomized noninferiority trial (predetermined measured outcome of intervention not worse than that of standard dosing schedule) in northwestern Vietnam to determine the immunogenicity (the ability of the
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Contact: Amy MacIver
amaciver@path.org
206-302-4522
JAMA and Archives Journals
Source:Eurekalert

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