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Length of biological marker associated with risk of cancer
Date:7/6/2010

ortest telomere length having the highest rate of cancer.

Short telomere length was also associated with a higher rate of death from cancer. "Of note, telomere length was preferentially associated with individual cancers characterized by a high fatality rate such as gastric, lung, and ovarian cancer, but less so with tumors linked to better prognosis," the authors write. They add that telomere length had a similar predictive value for cancer in both men and women and in various age groups.

"A variety of experimental and genetic studies support the hypothesis that telomere attrition contributes to the manifestation and dissemination of malignancies. While fully functional telomeres confer protection of the genome, shortened telomeres facilitate chromosomal instability," the researchers write.


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Contact: Stefan Kiechl, M.D.
stefan.kiechl@i-med.ac.at
JAMA and Archives Journals
Source:Eurekalert

Page: 1 2

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