Navigation Links
Length of biological marker associated with risk of cancer
Date:7/6/2010

A new study suggests that shorter length of leukocyte telomeres chromosome markers of biological aging are associated with an increased risk of cancer and death from cancer, according to a study in the July 7 issue of JAMA. A leukocyte is a type of blood cell.

Telomeres are a structure at the end of a chromosome involved in the replication and stability of the chromosome. Genetic factors and environmental stressors can shorten the length of the telomere, and telomere length has been considered to be an emerging marker of biological age. Some research has suggested that short telomeres and chromosomal instability contribute to malignant cell transformation. "Proof of concept for this intriguing hypothesis remains to be established from an epidemiological perspective," the authors write.

Peter Willeit, M.D., of Innsbruck Medical University, Innsbruck, Austria, and colleagues conducted a study to assess the association between leukocyte telomere length and risk of both new-onset cancer and cancer death. Leukocyte telomere length was measured by quantitative polymerase chain reaction (laboratory technique used to analyze DNA) in 787 participants, free of cancer in 1995, and part of the prospective, population-based Bruneck Study in Italy. The primary outcomes analyzed included the incidence of new cancer and cancer mortality over a follow-up period of 10 years (1995-2005).

During follow-up, a total of 92 of 787 participants (11.7 percent) developed cancer. Analysis indicated that short telomere length at the beginning of the study was associated with new cancer independently of standard cancer risk factors. Compared with participants in the longest telomere length group, participants in the middle length group had about twice the risk of cancer, and those in the shortest length group had approximately three times the risk. Cancer incidence rates were inversely related to telomere length, with participants in the group with the shortest telomere length having the highest rate of cancer.

Short telomere length was also associated with a higher rate of death from cancer. "Of note, telomere length was preferentially associated with individual cancers characterized by a high fatality rate such as gastric, lung, and ovarian cancer, but less so with tumors linked to better prognosis," the authors write. They add that telomere length had a similar predictive value for cancer in both men and women and in various age groups.

"A variety of experimental and genetic studies support the hypothesis that telomere attrition contributes to the manifestation and dissemination of malignancies. While fully functional telomeres confer protection of the genome, shortened telomeres facilitate chromosomal instability," the researchers write.


'/>"/>

Contact: Stefan Kiechl, M.D.
stefan.kiechl@i-med.ac.at
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Coverage of inexpensive drugs may increase length and quality of life after heart attack
2. Unequal leg length tied to osteoarthritis, says Queens professor
3. Cosmetic Peptides that Significantly Reduce Length and Depth of Wrinkles: Janet Sartin Introduces Advanced Anti-Wrinkle Peptide Serum for All Skin Types
4. Texas Childrens Cancer Center first in Texas to magnetically lengthen 9-year-olds leg as she grows
5. Antibody therapy lengthens survival of metastatic melanoma patients in large clinical trial
6. Shorter Telomere Length Again Linked to Cancer
7. Launch of ImmortalHumans.com as a Result of Humankind's Drive to Cure Aging and Become Biologically Immortal Within this Century
8. Biological catch-22 prevents induction of antibodies that block HIV
9. Study carried out into biological risks of eating reptiles
10. Biological clock could be a key to better health, longer life
11. New method to grow arteries could lead to biological bypass for heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... 2016 , ... Finally, a bruise cream that really works. Originally designed ... into the post-surgical treatment plans of a variety of other procedures including, but not ... effective for bruising and causes a rapid resolution of bruising and inflammatory changes compared ...
(Date:6/24/2016)... ... June 24, 2016 , ... Today, InhaleLabs.com (Inhale) offilially ... their medication by matching users with high quality water pipes within an ideal price ... commitment. , Inhale was founded by two brothers, Nick and Mike Hunter, who use ...
(Date:6/23/2016)... ... June 23, 2016 , ... Terumo BCT, ... organization responsible for clinical transfusion research programs and for the blood supply in ... Evaluation and Predictive Analytical Rating Score (PREPAReS) study. , Currently in its ...
(Date:6/23/2016)... ... June 23, 2016 , ... The Mechille Wilson Agency, ... throughout Jasper County and the surrounding region, is initiating a charity drive to assist ... raise funds earmarked for a scholarship fund that will be presented to the chosen ...
(Date:6/23/2016)... , ... June 23, 2016 , ... Representatives of CHA ... the newest member of their staff, Dr. Joshua J. Berger. As of May ... of the world-renowned facility. , Dr. Berger has received recognition for his research, his ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Global Blood Therapeutics, Inc. (GBT) (NASDAQ: ... novel therapeutics for the treatment of grievous blood-based ... closing of its previously announced underwritten public offering ... public offering price of $18.75 per share. All ... by GBT. GBT estimates net proceeds from the ...
(Date:6/24/2016)... 24, 2016 ... the addition of the " Global Markets for ... This report focuses on ... updated review, including its applications in various applications. The ... which includes three main industries: pharmaceutical and biotechnology, food ...
(Date:6/24/2016)... , June 24, 2016 The Academy of ... recommendations that would allow biopharmaceutical companies to ... entities that make formulary and coverage decisions, a move ... of new medicines. The recommendations address restrictions ... appear on the drug label, a prohibition that hinders ...
Breaking Medicine Technology: