Navigation Links
Length of biological marker associated with risk of cancer
Date:7/6/2010

A new study suggests that shorter length of leukocyte telomeres chromosome markers of biological aging are associated with an increased risk of cancer and death from cancer, according to a study in the July 7 issue of JAMA. A leukocyte is a type of blood cell.

Telomeres are a structure at the end of a chromosome involved in the replication and stability of the chromosome. Genetic factors and environmental stressors can shorten the length of the telomere, and telomere length has been considered to be an emerging marker of biological age. Some research has suggested that short telomeres and chromosomal instability contribute to malignant cell transformation. "Proof of concept for this intriguing hypothesis remains to be established from an epidemiological perspective," the authors write.

Peter Willeit, M.D., of Innsbruck Medical University, Innsbruck, Austria, and colleagues conducted a study to assess the association between leukocyte telomere length and risk of both new-onset cancer and cancer death. Leukocyte telomere length was measured by quantitative polymerase chain reaction (laboratory technique used to analyze DNA) in 787 participants, free of cancer in 1995, and part of the prospective, population-based Bruneck Study in Italy. The primary outcomes analyzed included the incidence of new cancer and cancer mortality over a follow-up period of 10 years (1995-2005).

During follow-up, a total of 92 of 787 participants (11.7 percent) developed cancer. Analysis indicated that short telomere length at the beginning of the study was associated with new cancer independently of standard cancer risk factors. Compared with participants in the longest telomere length group, participants in the middle length group had about twice the risk of cancer, and those in the shortest length group had approximately three times the risk. Cancer incidence rates were inversely related to telomere length, with participants in the group with the shortest telomere length having the highest rate of cancer.

Short telomere length was also associated with a higher rate of death from cancer. "Of note, telomere length was preferentially associated with individual cancers characterized by a high fatality rate such as gastric, lung, and ovarian cancer, but less so with tumors linked to better prognosis," the authors write. They add that telomere length had a similar predictive value for cancer in both men and women and in various age groups.

"A variety of experimental and genetic studies support the hypothesis that telomere attrition contributes to the manifestation and dissemination of malignancies. While fully functional telomeres confer protection of the genome, shortened telomeres facilitate chromosomal instability," the researchers write.


'/>"/>

Contact: Stefan Kiechl, M.D.
stefan.kiechl@i-med.ac.at
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Coverage of inexpensive drugs may increase length and quality of life after heart attack
2. Unequal leg length tied to osteoarthritis, says Queens professor
3. Cosmetic Peptides that Significantly Reduce Length and Depth of Wrinkles: Janet Sartin Introduces Advanced Anti-Wrinkle Peptide Serum for All Skin Types
4. Texas Childrens Cancer Center first in Texas to magnetically lengthen 9-year-olds leg as she grows
5. Antibody therapy lengthens survival of metastatic melanoma patients in large clinical trial
6. Shorter Telomere Length Again Linked to Cancer
7. Launch of ImmortalHumans.com as a Result of Humankind's Drive to Cure Aging and Become Biologically Immortal Within this Century
8. Biological catch-22 prevents induction of antibodies that block HIV
9. Study carried out into biological risks of eating reptiles
10. Biological clock could be a key to better health, longer life
11. New method to grow arteries could lead to biological bypass for heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... (PRWEB) , ... February 05, 2016 , ... Looking for ... may be at the tips of your toes. Foot massage, whether administered by a ... pure comfort and relaxation. The American Board of Multiple Specialties in Podiatry ...
(Date:2/5/2016)... San Rafael, CA (PRWEB) , ... February 05, 2016 , ... ... partnership with ChildLight Yoga Studio in Dover, NH to direct high-performance kids yoga training. ... on New Hampshire’s seacoast, just one hour from Boston. , ChildLight Yoga Studio founder ...
(Date:2/5/2016)... ... ... Give To Cure today announced that it is working with ... campaign that is crowdfunding clinical trials to help find cures faster for Alzheimer’s Disease. ... device. In 2015 alone, Venmo processed $7.5 billion in transactions among users. , Give ...
(Date:2/5/2016)... ... ... Dr. Justin Scott and Dr. Lydia Muccioli of Pure Dental Health ... need. The event is scheduled to take place on February 27, 2016 from 9am ... care to community members in need. Each patient will be given the opportunity to ...
(Date:2/5/2016)... ... 05, 2016 , ... In sleep, when the defenses of the day are ... of patients with eating disorders is significant self-criticism, and consequently these patients experience this ... regarded as maladaptive means for coping with this unease, but also leads to a ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... -- Wegener Polyangiitis - Pipeline Review, H2 2015 ... - Pipeline Review, H2 2015, provides an overview ... report provides comprehensive information on the therapeutic development ... various stages, therapeutics assessment by drug target, mechanism ... molecule type, along with latest updates, and featured ...
(Date:2/4/2016)... 4, 2016 Global Immunology Market to ... drive long-term market growth Summary Immune-mediated ... chronic disorders that affect 5–7% of western populations. ... their symptoms and key patient demographics, they are ... pathways and an inappropriate immune response. Generally, disease-modifying ...
(Date:2/4/2016)... Feb. 4, 2016 Mettler-Toledo International Inc. (NYSE: ... 2015.  Provided below are the highlights: , ... compared with the prior year.  Reported sales decreased 3% ... quarter. , Net earnings per diluted share as ... prior- year period.  Adjusted EPS was $4.65, an increase ...
Breaking Medicine Technology: