Navigation Links
Length of biological marker associated with risk of cancer
Date:7/6/2010

A new study suggests that shorter length of leukocyte telomeres chromosome markers of biological aging are associated with an increased risk of cancer and death from cancer, according to a study in the July 7 issue of JAMA. A leukocyte is a type of blood cell.

Telomeres are a structure at the end of a chromosome involved in the replication and stability of the chromosome. Genetic factors and environmental stressors can shorten the length of the telomere, and telomere length has been considered to be an emerging marker of biological age. Some research has suggested that short telomeres and chromosomal instability contribute to malignant cell transformation. "Proof of concept for this intriguing hypothesis remains to be established from an epidemiological perspective," the authors write.

Peter Willeit, M.D., of Innsbruck Medical University, Innsbruck, Austria, and colleagues conducted a study to assess the association between leukocyte telomere length and risk of both new-onset cancer and cancer death. Leukocyte telomere length was measured by quantitative polymerase chain reaction (laboratory technique used to analyze DNA) in 787 participants, free of cancer in 1995, and part of the prospective, population-based Bruneck Study in Italy. The primary outcomes analyzed included the incidence of new cancer and cancer mortality over a follow-up period of 10 years (1995-2005).

During follow-up, a total of 92 of 787 participants (11.7 percent) developed cancer. Analysis indicated that short telomere length at the beginning of the study was associated with new cancer independently of standard cancer risk factors. Compared with participants in the longest telomere length group, participants in the middle length group had about twice the risk of cancer, and those in the shortest length group had approximately three times the risk. Cancer incidence rates were inversely related to telomere length, with participants in the group with the shortest telomere length having the highest rate of cancer.

Short telomere length was also associated with a higher rate of death from cancer. "Of note, telomere length was preferentially associated with individual cancers characterized by a high fatality rate such as gastric, lung, and ovarian cancer, but less so with tumors linked to better prognosis," the authors write. They add that telomere length had a similar predictive value for cancer in both men and women and in various age groups.

"A variety of experimental and genetic studies support the hypothesis that telomere attrition contributes to the manifestation and dissemination of malignancies. While fully functional telomeres confer protection of the genome, shortened telomeres facilitate chromosomal instability," the researchers write.


'/>"/>

Contact: Stefan Kiechl, M.D.
stefan.kiechl@i-med.ac.at
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Coverage of inexpensive drugs may increase length and quality of life after heart attack
2. Unequal leg length tied to osteoarthritis, says Queens professor
3. Cosmetic Peptides that Significantly Reduce Length and Depth of Wrinkles: Janet Sartin Introduces Advanced Anti-Wrinkle Peptide Serum for All Skin Types
4. Texas Childrens Cancer Center first in Texas to magnetically lengthen 9-year-olds leg as she grows
5. Antibody therapy lengthens survival of metastatic melanoma patients in large clinical trial
6. Shorter Telomere Length Again Linked to Cancer
7. Launch of ImmortalHumans.com as a Result of Humankind's Drive to Cure Aging and Become Biologically Immortal Within this Century
8. Biological catch-22 prevents induction of antibodies that block HIV
9. Study carried out into biological risks of eating reptiles
10. Biological clock could be a key to better health, longer life
11. New method to grow arteries could lead to biological bypass for heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... 28, 2017 , ... AutismOne announced the Board Certified in ... Medicine and available for application on Saturday, May 27, 2017, following Thursday, Friday, ... Springs. , Ed Arranga, president of AutismOne, stated: "Many of the modalities termed ...
(Date:3/28/2017)... ... 2017 , ... Public relations pros work hard to earn placements and ... While many results are clear, much of PR is hard to quantify. Goal-setting and ... to measurement, firms should always take an all-inclusive approach that takes both traditional and ...
(Date:3/28/2017)... ... 2017 , ... With expansion and efficiency in mind, Patten Seed Company completed ... processing plant opened in Marshallville in 2006, and a bagging and shipping facility has ... transition of Patten Seed operations to the Middle Georgia location from their previous home ...
(Date:3/28/2017)... ... 2017 , ... Oily skin is a common and unwelcomed occurrence in people of all ages, ... to offer to the discussion of dealing with excess skin oil. “Oily skin is a ... remedies that can help remove the oily shine while keeping the skin fresh and clean,” ...
(Date:3/28/2017)... ... 28, 2017 , ... Nurse practitioners and physician assistants are ... in the healthcare workforce, according to a survey recently released by PracticeMatch ... candidate leads to healthcare employers of physicians and advanced practice clinicians. , Only ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... Calif. , March 27, 2017  Cryoport, Inc. ... that it intends to offer shares of common stock ... registration statement on file with the Securities and Exchange ... and other conditions, and there can be no assurance ... completed, or as to the actual size or terms ...
(Date:3/27/2017)... , March 27, 2017 ... attendees and more than 600 exhibitors from 70 ... opportunities and solutions that will advance the medical ... 2017 at the Messe Stuttgart, Stuttgart, ... medical technology platform showcasing the key trends and ...
(Date:3/27/2017)... , March 27, 2017  Sanderling Ventures, ... by Ethicon, a division of Johnson & Johnson. Torax ... for the treatment of gastro-esophageal reflux disease (GERD). ... augmentation (MSA) technology and the procedure is currently ... Torax Medical was founded by Sanderling ...
Breaking Medicine Technology: