Navigation Links
Lenalidomide prolongs disease control for multiple myeloma patients after stem cell transplant

PORTLAND, Ore. Multiple myeloma patients are better equipped to halt progression of this blood cancer if treated with lenalidomide, or Revlimid, following a stem cell transplant, according to a study co-authored by a physician with the Oregon Health & Science University Knight Cancer Institute.

The study, published in the New England Journal of Medicine, found a 63 percent reduction in the risk of progressive myeloma or death for the stem cell transplant patients that were treated with lenalidomide maintenance therapy.

"These results add to the evidence that the combination of standard therapies such as stem cell transplantation with the emerging biologic therapies, like lenalidomide, have extended the lives of multiple myeloma patients," said Richard Maziarz, M.D., of the OHSU Knight Cancer Institute who was one of the study's co-authors. Maziarz serves as medical director of the Adult Stem Cell Transplantation Program & Center for Hematologic Malignancies at the OHSU Knight Cancer Institute. "We know that for at least three years following a transplant that maintenance therapy with this drug vastly improves the chances that the cancer won't come back and worsen."

These data were supported by similar Phase III studies reported from France and Italy in the same issue of the New England Jounal of Medicine demonstrating that maintenance therapy after stem cell transplantation was associated with improved disease control.

Multiple myeloma is a cancer that affects plasma cells, a type of white blood cell normally responsible for producing antibodies. In patients impacted by multiple myeloma, collections of abnormal plasma cells accumulate in the bone marrow, interfering with the production of normal blood cells. The study focused on patients who received an autologous hematopoietic cell transplant (AHCT). AHCT procedures use patients' own blood stem cells.

While lenalidomide increased a patient's ability to stave off progression of the disease, questions remain regarding future approaches recognizing that quality of life measurements were not incorporated within these studies, that long-term safety issues remain unclear as there was a small but discernable risk of second cancers observed in the treated patients. In addition to the need for that cost-benefit analysis, a comparison remains to be performed with other emerging myeloma maintenance therapies.

This Phase III study of lenalidomide was conducted at 47 medical centers and involved 568 patients. It was sponsored by the National Cancer Institute (NCI). Revlimid's manufacturer, Celgene Corp., provided the NCI with lenalidomide for this research.


Contact: Elisa Williams
Oregon Health & Science University

Related medicine news :

1. Study urges caution with lenalidomide dosage
2. How to recognize at an early stage whether a new cancer therapy prolongs life
3. Everolimus prolongs progression-free survival for patients with neuroendocrine tumors
4. Early life stress may predict cardiovascular disease
5. Study finds racial gaps continue in heart disease awareness
6. Bowel disease link to blood clots
7. Womens Heart Disease Awareness Still Lacking
8. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
9. New Study Uses Adult Stem Cells in Effort to Save Limbs of Patients with Peripheral Arterial Disease
10. Patients with Lethal Lung Disease Finally Receive Recognition by Social Security Administration
11. Alzheimers Foundation of America Applauds Social Security for Speeding Disability Benefits for Early-Onset Alzheimers Disease
Post Your Comments:
Related Image:
Lenalidomide prolongs disease control for multiple myeloma patients after stem cell transplant
(Date:11/30/2015)... ... November 30, 2015 , ... Using a combination of two blood ... children and adults, according to a new study by researchers at the School of ... Children and Adults: Using Combinations of Blood Glucose Tests ,” published in Frontiers in ...
(Date:11/30/2015)... ... November 30, 2015 , ... Newly reviewed and approved “NJ Top ... from Tufts School of Dental Medicine in 1935. His father graduated from NYU ... being in dentistry as well as their commitment and passion to the Practice of ...
(Date:11/30/2015)... York, NY (PRWEB) , ... November 30, 2015 , ... ... York Times,” will be released on December 1, 2015, to coincide with World AIDS ... about the groundbreaking journalist who covered the AIDS epidemic as he was dying of ...
(Date:11/30/2015)... ... November 30, 2015 , ... The American Society for ... honor of World AIDS Day 2015. On Nov. 30, ASCP shared its “Give a ... about World AIDS Day and the importance of getting tested for HIV. , ASCP ...
(Date:11/30/2015)... ... 30, 2015 , ... California-based i2i Systems, a pioneer defining ... Michigan-based Family Health Center (FHC) has selected i2iTracks as their population health management ... the largest Affordable Care Act grant for Federally Qualified Health Centers in the ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... , Nov. 30, 2015 Nautilus Medical ... Radiology Image Management platform ( ). The release ... announced from RSNA 2015 (Radiology Society North America) in ... conference in the U.S. --> ... platform that enables access to radiology studies worldwide via ...
(Date:11/30/2015)... North America was valued ... at a CAGR of 7.6% from 2015 to 2020. --> ... million in 2014, and is expected to grow at a CAGR ... the new Market Research Report "North America Cardiac Output Monitoring Devices ... ambulatory care, others) - Analysis And Forecast To 2020", the cardiac ...
(Date:11/30/2015)... 30, 2015 ... adds a 2015 publication on ... 2015 with comprehensive analysis of recent ... deal types, such as Mergers & ... . --> ...
Breaking Medicine Technology: