Navigation Links
Leeds researchers reshape the future of drug discovery
Date:11/18/2008

Co-researcher Dr Stuart Warriner added: "Making molecules is a bit like making something using lego bricks. Up until now we've only really become good at making, say, the equivalent of a lego car or train. There might be 30 million synthetic molecules registered, but there's probably several million of these that are the equivalent of lego cars they may have different wheels and wing mirrors, but their fundamental shape is essentially the same. We've not really scratched the surface of the possible structures that could be made. This lack of variety in the core shape of molecules may well limit the range of proteins that medicinal chemists can target."

The Leeds approach makes use of 'metathesis', a reaction that won the 2005 Nobel Prize in Chemistry.

Explains Professor Nelson: "We take simple building blocks, a bit like the amino acids that make up peptides, and we assemble them in different sequences using three simple reactions to link them together in a chain. The key difference is that we then add the catalyst which initiates a 'scaffold reprogramming reaction', which ripples down the chemical chain and restitches the molecule together in a completely different way each time.

"It's a bit like a molecular square dance, where atoms in the molecule swap partners - and the exciting thing is that we can change the building blocks again and again in different combinations as a really powerful way to vary the core frameworks that result. The potential of this process is enormous," he says.

The team from Leeds have used their approach to prepare molecules with 84 distinct molecular frameworks and about two-thirds of the frameworks are unprecedented in the history of organic chemistry. The work is a huge leap forward from landmark research reported in 2003, which resulted in the creation of six frameworks in a single process. It is also a significant improvement on more recent research in which around 30 frameworks were created
'/>"/>

Contact: Professor Adam Nelson
a.s.nelson@leeds.ac.uk
44-011-334-36502
University of Leeds
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Leeds medics solve an ancient riddle -- and offer new tool for diagnosis
2. UNC researchers find clue to stopping breast-cancer metastasis
3. U of U researchers to use patients own stem cells to treat heart failure
4. Researchers identify toehold for HIVs assault on brain
5. Researchers Tackle CLL, Diabetes and Trauma-Hemorrhage
6. Researchers Use New Method to Control Bleeding in Hemophilia
7. Stem cells with potential to regenerate injured liver tissue identified by Penn researchers
8. Protein can nurture or devastate brain cells, depending on its friends, researchers find
9. Researchers find stem cells from monkey teeth can stimulate growth and generation of brain cells
10. Battling Bacteria in the Blood: U-M Researchers Tackle Deadly Infections
11. Researchers to Present Additional Data on Soliris(R) (eculizumab) for the Treatment of PNH at the ASH Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... MD (April 23, 2014) The American Gastroenterological ... the 2014 AGA Research Scholars. The AGA Research ... investigators to develop independent and productive research careers ... Scholar Awards fund an additional year allowing for ... committed to supporting junior faculty who are paving ...
(Date:4/23/2014)... in the popular Swedish children,s TV show Bolibompa, ... A new study from the University of Gothenburg ... programmes as well as the link between young ... , Steingerdur Olafsdottir,s doctoral thesis focuses on the ... TV show Bolibompa. Healthy foods dominated in the ...
(Date:4/23/2014)... Five for-profit and non-profit organizations in Washington ... Proof of Concept grants to accelerate maturation of ... the Life Sciences Discovery Fund (LSDF) announced today. ... grant to the Washington Biotechnology & Biomedical Association ... train the next generation of entrepreneurs and help ...
(Date:4/23/2014)... an increase in adolescents, marijuana use following the legalization ... According to a new study at Rhode Island Hospital ... with and without medical marijuana laws, legalizing the drug ... study is published online in advance of print in ... "Any time a state considers legalizing medical marijuana, there ...
(Date:4/23/2014)... Oncotarget , explored tumour heterogeneity where different ... signatures within the same cancer. Such differences could ... strategies. , Firstly they confirmed the mutual exclusivity ... or BRAF mutation. Secondly, they found that lung ... that specific mutation present uniformly throughout the tumour, ...
Breaking Medicine News(10 mins):Health News:AGA announces 2014 Class of AGA Research Scholars 2Health News:High-calorie and low-nutrient foods in kids' TV 2Health News:LSDF announces commercialization grants and Entrepreneur Mentoring Program 2Health News:RI Hospital physician: Legalizing medical marijuana doesn't increase use among adolescents 2Health News:Non-uniform genetic mutations identified in lung cancers could lead to targeted treatment 2
... Health Magazine, SEATTLE, June 5 Kagome, one ... Mango Orchard natural 100 percent juice,blend have been named ... With the help of top health experts, Health ... fitness to the ultimate test,and unveiled a total of ...
... influences fat metabolism , , THURSDAY, June 5 (HealthDay News) ... truism familiar to the diet-conscious choosing between carrots and ... isn,t just a matter of what you put in ... genetically predisposed to process fat. , The theory is ...
... The U. S. Army Corps of,Engineers, in partnership ... and recreation industry partners, will,participate in the first ... On this day, more than 75 organizations will ... privately-managed recreation sites,across the country according to event ...
... veterinarians perform leading-edge techniques and,identify animal research ... both,horses and humans, WASHINGTON, June 5 ... releases its feature film Majestic starring some,of ... Bramlage (Rood & Riddle,Equine Hospital) and Dr. ...
... naturally occurring fat molecule have the potential to slow ... researchers report. , Through both the normal aging ... skin inevitably becomes coarse and wrinkled. The basis of ... the production of new collagen while increasing the levels ...
... percent of patients who recently underwent liver transplantation ... factors included having had biliary-enteric anastomosis (choledocho-jejunal or ... more than four red blood cell units transfused. ... of Liver Transplantation, a journal by John Wiley ...
Cached Medicine News:Health News:Kagome's Yellow Mango Orchard Blended Juice Named One of America's Healthiest Buys 2Health News:Kagome's Yellow Mango Orchard Blended Juice Named One of America's Healthiest Buys 3Health News:Weight Gain May Not Be Based Just on What You Eat 2Health News:Weight Gain May Not Be Based Just on What You Eat 3Health News:Army Corps of Engineers Will Host National Get Outdoors Day Activities at Six Corps Project Sites 2Health News:The Foundation for Biomedical Research (FBR) Releases Feature DVD Majestic for World Premiere 2Health News:Researchers determine risk factors for infection after liver transplantation 2
(Date:1/14/2014)... Healthcare Services, Inc. ("DHS"), a portfolio company of GMH Ventures ... Equipment, Inc. ("Progressive") of Clarion, PA ... not disclosed. Progressive is a full service ... sleep, mobility, and respiratory products to customers in the western ...
(Date:1/14/2014)... Va. , Jan. 14, 2014 Animal Emergency Critical Care, ... Leesburg, Virginia is the first in ... oxygen chamber. Dr. Susan M. Barnes , ... Dr. Barnes and husband, Dr. Cole Taylor , are avid ...
(Date:1/14/2014)... NineSigma , Inc., the leading innovation partner ... Summit , May 14-16, 2014 at the Global Center ... . This is the premier industry ... achievements through open innovation. Participants will learn how world-changing ...
Breaking Medicine Technology:Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 4
... launched ABAS ( Atlas-based Autosegmentation ) 2.0 software, ... Estimation (STAPLE) algorithm to increase contouring accuracy. ABAS—considered ... of anatomy previously defined on a reference image ... structure set fit to the patient anatomy and ...
... Pa., Oct. 1 Encorium Group, Inc. (Nasdaq: ... conducting studies in over 30 countries for many of the ... has extended the expiration date for its pending rights offering ... rights may now be exercised at any time prior to ...
Cached Medicine Technology:Elekta Launches ABAS 2.0 Autosegmentation Software Used to Plan Radiation Therapy in Patients With Cancer 2Encorium Group, Inc. Extends Expiration of Its Pending Rights Offering 2Encorium Group, Inc. Extends Expiration of Its Pending Rights Offering 3Encorium Group, Inc. Extends Expiration of Its Pending Rights Offering 4Encorium Group, Inc. Extends Expiration of Its Pending Rights Offering 5Encorium Group, Inc. Extends Expiration of Its Pending Rights Offering 6
... is highly adaptable and therefore suitable for ... to its extraordinary small outer diameter and ... of a simple but secure and reliable ... steering instruments around the corner. These characteristics ...
... images are transmitted through sorted ... picture and transmit it to ... flexoscopes are designed for rough, ... repaired at low cost if ...
A new flexible endoscope with an ultra dense optic fiber system. Its two working and irrigation channels and steering mechanism makes it ideal for a multipurpose use in neurosurgical endoscopy i.e. V...
Bipolar gingivoplasty loop. Individual sterile packs....
Medicine Products: