Navigation Links
Leeds researchers reshape the future of drug discovery
Date:11/18/2008

Scientists in Leeds have devised a new way to create the next generation of man-made molecules in a breakthrough that could revolutionise drug development.

Creating new drugs to combat disease and illness requires the completion of a complex 3D jigsaw. The shape of the drug must be right to allow it to bind to a specific disease-related protein and to work effectively, and this shape is determined by the core framework of the molecule.

Now a team from the Astbury Centre for Structural Molecular Biology at the University of Leeds has developed a new approach which allows the creation of molecules with an extraordinarily wide range of molecular frameworks and, hence, shapes. The new molecules are likely to have a wide range of biological functions, which means they could be valuable starting points for the discovery of new drugs.

Says lead researcher Professor Adam Nelson of the University's School of Chemistry: "Nature has created hundreds of thousands of molecules that have different frameworks and biological purposes, but in the global pursuit of new drugs, chemists from around the world are racing to create new molecules with functions not seen in nature."

The newly created molecules are being shared with colleagues in the Faculties of Biological Sciences and Medicine and Health to see if specific new molecular frameworks match the requirements of their own research.

Of the 30 million or so synthetic molecules made throughout the history of organic chemistry, many are based on an extremely small number of core frameworks, with the main differences being the groups attached at the periphery. "Making collections of similar molecules is great for optimising a biological property," says Professor Nelson, "but to put it simply, if researchers need a cube-shaped molecule to target a particular protein, they may well find that they can only choose from libraries stocked with millions of sphere-shaped ones."


'/>"/>

Contact: Professor Adam Nelson
a.s.nelson@leeds.ac.uk
44-011-334-36502
University of Leeds
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Leeds medics solve an ancient riddle -- and offer new tool for diagnosis
2. UNC researchers find clue to stopping breast-cancer metastasis
3. U of U researchers to use patients own stem cells to treat heart failure
4. Researchers identify toehold for HIVs assault on brain
5. Researchers Tackle CLL, Diabetes and Trauma-Hemorrhage
6. Researchers Use New Method to Control Bleeding in Hemophilia
7. Stem cells with potential to regenerate injured liver tissue identified by Penn researchers
8. Protein can nurture or devastate brain cells, depending on its friends, researchers find
9. Researchers find stem cells from monkey teeth can stimulate growth and generation of brain cells
10. Battling Bacteria in the Blood: U-M Researchers Tackle Deadly Infections
11. Researchers to Present Additional Data on Soliris(R) (eculizumab) for the Treatment of PNH at the ASH Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2015)... 2015 The PracticeMatch Career Fair ... 8:00 pm at the Sheraton Colonial Boston North Hotel, 1 ... and groups with career opportunities will be attending from across ... free hors d’oeuvres and raffle prize drawings. , Leslie Thompson, ... is an ideal location to hold a career fair. In ...
(Date:4/28/2015)... April 28, 2015 The Awareness Counselor team ... common topic of judging. According to Awareness Counselor, there are ... when directed outward, and to an individual who self-judges. This ... clients as a class or one one one talk. , ... of Awareness Counselor, is that every being on earth is ...
(Date:4/28/2015)... Aliso Viejo, CA (PRWEB) April 28, 2015 ... created for use in Final Cut Pro X ... attention to specific areas on-screen with classic buttons, animated ... Annotate is the perfect compliment to vlogs, video series, ... Cut Pro X 10.2 or newer. ProTube Annotate ...
(Date:4/28/2015)... PREVENT Life Safety, Inc., America’s premier provider ... their Southern California offices from Orange, California to Rancho ... I (letter I), Rancho Cucamonga, CA, 91730, is effective ... the significant growth the company has realized in the ... to provide superior life safety services, including fire damper ...
(Date:4/27/2015)... 2015 Medical Device Design Control , ... Ombu Enterprises**, June 16-17, 2015 – Chicago, IL , ... to a facility today, would the design control system ... is "maybe" or "no" … then very likely there ... a solution. , Take this important step. Enroll ...
Breaking Medicine News(10 mins):Health News:PracticeMatch to Host Physician Career Fair at Sheraton Colonial Boston North Hotel on May 6, 2015 2Health News:PracticeMatch to Host Physician Career Fair at Sheraton Colonial Boston North Hotel on May 6, 2015 3Health News:What Happens When We Judge Ourselves and Others? – A New Concept Introduced 2Health News:What Happens When We Judge Ourselves and Others? – A New Concept Introduced 3Health News:FCPX plugin developer Pixel Film Studios releases Protube Annotate plugin for Final Cut Pro X. 2Health News:PREVENT Life Safety Moves to New Office in Rancho Cucamonga 2Health News:FDAnews Announces: Medical Device Design Control: Implementing an Approach That Works, June 16-17, Chicago, IL 2Health News:FDAnews Announces: Medical Device Design Control: Implementing an Approach That Works, June 16-17, Chicago, IL 3Health News:FDAnews Announces: Medical Device Design Control: Implementing an Approach That Works, June 16-17, Chicago, IL 4
... smokers twice as likely to have strokes, they are almost ... to a study presented today at the Canadian Stroke Congress. ... stroke patients (264 smokers and 718 non-smokers) at an Ottawa ... who smoked was 58, compared to age 67 for non-smokers. ...
... in South Africa and Brazil become happier as they age. ... a developing country can significantly improve the wellbeing of its ... older people in South Africa and Brazil improved between 2002 ... enlightened social policies, according to a study from the New ...
... By Amanda Gardner HealthDay Reporter , FRIDAY, ... United States, which reached a record high last year, are ... So far this year, some 200 drug shortages have ... Jensen, associate director of the Drug Shortage Program within the ...
... using a 320 detector row CT scanner found that a ... sufficient enhancement in more than 96% of coronary segments," said ... and one of the authors of the study. ... equal to 80 milliliters of iopamidol," he said. The ...
... such as depression, obsessive-compulsive disorder or anxiety states ... of the neurotransmitter serotonin. Neurotransmitters are compounds that ... endings and activate the firing of neighboring neurons. ... transmission of nerve impulses. The serotonin transporter (SERT) ...
... women experience peer pressure to share sexual images via the ... Melbourne study has found. ,Sexting, is the practice of ... The study is one of the first academic investigations ... findings were presented to the 2011 Australasian Sexual Health Conference ...
Cached Medicine News:Health News:Smoking causes stroke to occur 2Health News:Older people are happier in Brazil and South Africa 2Health News:Drug Shortages Even Worse This Year: FDA 2Health News:Combating mood disorders 2Health News:'Sexting' driven by peer pressure 2
(Date:4/27/2015)... , April 27, 2015  CryoLife, Inc. (NYSE: ... processing company focused on cardiac and vascular surgery, announced ... the United States Food and Drug Administration ("FDA") verifying ... in place following the warning letter it received from ... letter follows a re-inspection in March 2015 by the ...
(Date:4/27/2015)... Va. and WASHINGTON , ... Specialty Pharmacy (NASP) and SmartBrief recently partnered to deliver ... a snapshot of the top news in the industry. ... pharmacies, pharmaceutical and biotechnology manufacturers, GPOs, distributors and other ... resource will launch on April 27, 2015. ...
(Date:4/27/2015)... Demonstrating the power of partnership within the medtech community, ... produce a world class medical technology conference in conjunction ... 2015, at the Minneapolis Convention ... combined 2015 Minneapolis event is expected to bring in ... under one roof, offering a great networking opportunity for ...
Breaking Medicine Technology:CryoLife Announces Resolution of FDA Warning Letter 2NASP and SmartBrief Partner on Specialty Pharmacy SmartBrief 2LifeScience Alley and MD&M Minneapolis partner for Minnesota Medtech Week 2LifeScience Alley and MD&M Minneapolis partner for Minnesota Medtech Week 3
MP-250N and 300N is a new style power supply. It is a versatile microprocessor power supply for horizontal or vertical gel electrophoresis. The unit is programmable and offers constant voltage and co...
... ZOOM® Dual Power is a microprocessor-controlled ... both high voltage/low current and high ... voltage/low current section is ideal for ... DNA sequencing applications. The low voltage/high ...
... Power Supply is designed specifically ... extensive programming capabilities including eight ... for you to set to ... intuitive PowerEase interface is faster ...
PS2A200 Power supply is a high current power supply ideal for all types of electrophoresis blotting and short electrophoresis runs....
Medicine Products: