Navigation Links
Led by advances in chemical synthesis, scientists find natural product shows pain-killing properties
Date:5/23/2011

JUPITER, FL, May 23, 2011 Scientists from the Florida campus of The Scripps Research Institute have for the first time accomplished a laboratory synthesis of a rare natural product isolated from the bark of a plant widely employed in traditional medicine. This advance may provide the scientific foundation to develop an effective alternative to commonly prescribed narcotic pain treatments.

The study, published May 23, 2011, in an advanced online edition of the journal Nature Chemistry, defines a chemical means to access meaningful quantities of the rare natural product conolidine. Based on data from mouse models, the study also suggests that synthetic conolidine is a potent analgesic as effective as morphine in alleviating inflammatory and acute pain, with few, if any, side effects.

In recent years, there has been significant interest in developing alternatives to opiate-based pain medications such as morphine. While widely prescribed for pain, morphine has a number of adverse side effects that range from the unpleasant to the lethal, including nausea, chronic constipation, addiction, and breathing depression.

The rare natural product central to the study is derived from the bark of a widely grown tropical flowering plant Tabernaemontana divaricata (also known as crepe jasmine). Long part of traditional medicine in China, Thailand, and India, extract from the leaves has been used as an anti-inflammatory applied to wounds, while the root has been chewed to fight the pain of toothache. Other parts of the plant have been used to treat skin diseases and cancer.

Conolidine belongs to a larger class of natural products, called C5-nor stemmadenines, members of which have been described as opioid analgesics, despite a substantial discrepancy between potent in vivo analgesic properties and low affinity to opiate receptors. Conolidine is an exceptionally rare member of this family for which no therapeutically relevant propert
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Senate Committee Advances Disastrous Idaho Health Freedom Act
2. Neutrons poised to play big role in future scientific advances
3. SeqWright Advances Genomic Discovery With Isilon IQ
4. Greenway Medical Technologies Advances Patient-Provider Benefits
5. Fifty years of the light fantastic: Laser advances spark scientific progress
6. South Carolina Senate Banking & Insurance Committee Advances Medigap Bill to Full Senate by Overwhelming Vote
7. Leading Orthopaedic Surgeon and Regenerative Medical Authority Dr. Thomas A. Einhorn Advances Adult Stem Cell Therapy To Eliminate Hip Replacement Surgery
8. Advances in personalized medicine take center stage
9. Researchers make advances in understanding causes, treatments and outcomes of liver disease
10. Mayo Clinic researcher details next-era advances in use of scopes for cancer detection
11. Rochester advances understanding of deadly form of malaria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... HealthDay Reporter , MONDAY, Nov. ... verge of burning out are more likely to develop heart ... vital exhaustion -- a toxic combination of fatigue, irritability and ... heart disease, researchers report. "In our increasingly busy lives, ... when that stress is left unchecked for a period of ...
(Date:11/18/2014)... By Dennis Thompson HealthDay ... doctor from Sierra Leone who became infected with Ebola in his ... Dr. Martin Salia had arrived Saturday at Nebraska Medical Center ... at a hospital in Sierra Leone,s capital city of Freetown. ... that have been ravaged by the Ebola outbreak that began last ...
(Date:11/18/2014)... HealthDay Reporter MONDAY, Nov. 17, 2014 (HealthDay ... them track how many calories they consume each day, but ... one after their doctor recommended it did not lose any ... using such apps as weight-loss tools. Some participants were barely ... varied, the researchers noted, and they added that they believe ...
(Date:11/17/2014)... 2014 Vernon Brewer, Founder and President of ... two weeks and saw firsthand the devastating holocaust that ISIS ... Iraq and Syria. , “‘Holocaust’ is not a term I ... or driven thousands of Christians and members of other faiths ... is desperate. As ISIS expands, they continue to kill ...
(Date:11/17/2014)... November 17, 2014 Home Care Assistance ... provider of non-medical, in-home senior care, is advising seniors ... , Aging typically weakens the immune system and makes ... the flu. This is a greater concern at this ... more prevalent; during last year’s influenza season (November to ...
Breaking Medicine News(10 mins):Health News:Feeling 'Worn Out'? Your Heart May Pay the Price 2Health News:Feeling 'Worn Out'? Your Heart May Pay the Price 3Health News:Doctor With Ebola Dies at Nebraska Hospital 2Health News:Calorie-Tracking Apps May Not Help You Lose Weight 2Health News:Calorie-Tracking Apps May Not Help You Lose Weight 3Health News:President of WORLD HELP Travels to Iraq and Jordan; Finds Religious Holocaust Being Executed by ISIS 2Health News:President of WORLD HELP Travels to Iraq and Jordan; Finds Religious Holocaust Being Executed by ISIS 3Health News:Home Care Assistance – Halton/Peel Region, a Top Provider of In-Home Care, Encourages Seniors to Get Annual Flu Shot 2Health News:Home Care Assistance – Halton/Peel Region, a Top Provider of In-Home Care, Encourages Seniors to Get Annual Flu Shot 3
... smell better is due to the boding of the hormone, ... age are far better in sensing the fragrance than men ... said: "Some studies have shown that during ovulation, there's a ... nose is the same in women as men. Theories have ...
... common problem for heavy drinkers and the scientist have found ... the potentialities of a night out. ,Researchers at the ... in Minnesota say the effect of alcohol on blood vessels ... healthy young adults, that blood vessels do not strengthen so ...
... weekend alcohol flings and the stress of going back to ... heart attack. A 7 year study carried out in Australia ... attacks on a Monday than any other day. ,Experts ... exorbitant drinking and coronary heart disease.//They suggested the stresses of ...
... putting its best foot forward in completing its ... company promote Zyban, its anti-smoking drug. Glaxo is ... of its policy, along with providing teams to ... of the corporate, which have negotiated for this ...
... prevented in prostate cancer patients who are undergoing ... The researchers at the New York Cornell Medical ... be considered as a monotherapy in men who ... the researchers evaluated 54 patients with clinically localised ...
... Brain surgery, endoscopies and other complicated medical procedures could ... using computers. Scientists from the University of California, Los ... interact with their environment and are attempting to design ... surgeons routinely use technology that is capable of producing ...
Cached Medicine News:
(Date:11/18/2014)... 2014  Zimmer Holdings, Inc. (NYSE and SIX: ZMH) ... European Commission (the "EC") to extend the deadline for ... by a limited number of days in order to ... Deadline extensions are not uncommon in such in-depth ... authorities to facilitate their review of the pending transaction ...
(Date:11/18/2014)... Pharmaceuticals, Inc. (NASDAQ: ISIS ) announced today that ... 2014 at 9:00 a.m. Eastern Time to discuss the ISIS-FXI ... Society of Hematology Annual Meeting and Exposition.  ... or access the webcast at www.isispharm.com .  A webcast ... same address. ABOUT ISIS PHARMACEUTICALS, INC. ...
(Date:11/18/2014)... 18, 2014  AgeneBio, a pharmaceutical company developing ... restore brain function, today announced that the Company,s ... , PhD, has received the Society for Neuroscience,s ... 35 years, Dr. Gallagher,s research at Johns Hopkins ... Hill has led to advancements in the field ...
Breaking Medicine Technology:Zimmer Provides Update on the European Commission Review Process Relating to the Pending Merger with Biomet, Inc. 2Zimmer Provides Update on the European Commission Review Process Relating to the Pending Merger with Biomet, Inc. 3Zimmer Provides Update on the European Commission Review Process Relating to the Pending Merger with Biomet, Inc. 4Zimmer Provides Update on the European Commission Review Process Relating to the Pending Merger with Biomet, Inc. 5Isis Pharmaceuticals to Host Webcast to Discuss ISIS-FXI Rx Data Presented at the ASH Annual Meeting 2Isis Pharmaceuticals to Host Webcast to Discuss ISIS-FXI Rx Data Presented at the ASH Annual Meeting 3AgeneBio Founder and Chief Scientific Officer Receives Society for Neuroscience's Mika Salpeter Lifetime Achievement Award 2AgeneBio Founder and Chief Scientific Officer Receives Society for Neuroscience's Mika Salpeter Lifetime Achievement Award 3
... Diagnostic, Non-Donor Screen. Vironostika HIV assays ... for additional testing and confirmation. Vironostika ... assay for the detection of antibody to ... spots. Oral Fluid Vironostika HIV-1 Microelisa ...
... OraSure HIV-1 Oral Specimen Collection Device is a ... HIV-1 antibodies. Testing with the OraSure HIV-1 Oral ... and has been shown to be more than ... treated cotton fiber pad attached to a nylon ...
... Angle CHS System takes the time proven ... , ,The VHS® Supracondylar Cable Plate is ... distal femur fractures including periprosthetic fractures. The ... variable angle of the barrel and the ...
Coronet Vacuum Trephine - All metal, ergonomic design and ultra sharp blade with cross hairs....
Medicine Products: