Navigation Links
Learning keeps brain healthy, UCI researchers find
Date:3/2/2010

Irvine, Calif., March 1, 2010 UC Irvine neurobiologists are providing the first visual evidence that learning promotes brain health and, therefore, that mental stimulation could limit the debilitating effects of aging on memory and the mind.

Using a novel visualization technique they devised to study memory, a research team led by Lulu Chen and Christine Gall found that everyday forms of learning animate neuron receptors that help keep brain cells functioning at optimum levels.

These receptors are activated by a protein called brain-derived neurotrophic factor, which facilitates the growth and differentiation of the connections, or synapses, responsible for communication among neurons. BDNF is key in the formation of memories.

"The findings confirm a critical relationship between learning and brain growth and point to ways we can amplify that relationship through possible future treatments," says Chen, a graduate researcher in anatomy & neurobiology.

Study results appear in the early online edition of the Proceedings of the National Academy of Sciences for the week of March 1.

In addition to discovering that brain activity sets off BDNF signaling at the sites where neurons develop synapses, researchers determined that this process is linked to learning-related brain rhythms, called theta rhythms, vital to the encoding of new memories.

Theta rhythms occurring in the hippocampus involve numerous neurons firing synchronously at a rate of three to eight times per second. These rhythms have been associated with long-term potentiation, a cellular mechanism underlying learning and memory.

In rodent studies, the team found that both unsupervised learning and artificial application of theta rhythms triggered BDNF signaling at synapse creation sites.

"This relationship has implications for maintaining good brain health," says Gall, a professor of anatomy & neurobiology. "There is evidence that theta rhythms weaken as we age, and our discoveries suggest that this can result in memory impairment. On the other hand, they suggest that staying mentally active as we age can keep neuronal BDNF signaling at a constant rate, which may limit memory and cognitive decline."

Researchers are now exploring whether learning-induced growth signals decrease with age and, if so, whether this can be reversed with a new family of experimental drugs.


'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Related medicine news :

1. UM School of Medicine finds prenatal cocaine exposure not severely damaging to growth, learning
2. Rapamycin rescues learning, memory in Alzheimers mouse model
3. Word learning in deaf children with cochlear implants
4. A midday nap markedly boosts the brains learning capacity
5. H1N1 learnings: Risk factors for severe outcomes among patients admitted to hospital with H1N1
6. Learning Lab of Brentwood Leads Free ADHD Seminar
7. Silverchair Learning Systems Enhances Product Expertise with New Hires
8. eTeacher Solutes TuBishvat- the “New Year for Trees” by Planting a Tree for Each Student Learning Modern or Biblical Hebrew
9. Six Key Areas of Learning for Pharmaceutical and Healthcare Marketing in 2010
10. Medichest Launches Learning Search
11. Epocrates and RealCME Unite to Deliver Enhanced e-Learning Offerings
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... ... March 30, 2017 , ... Sublime Naturals and its ... Life" or "Wonder Spice", it has been used for thousands of years. , "The ... says Heshelow, author of " Turmeric: How to Use it For Your Wellness. Overcome ...
(Date:3/29/2017)... ... March 29, 2017 , ... AngioGenesis Labs sold 300 ... Mississippi. AngioGenesis Labs, makers of HeartBoost, BrainBest and BeautyBest, achieved these results while ... HeartBoost, an over the counter heart healthy drink, can reduce Arterial Plaque, Lower ...
(Date:3/29/2017)... OK (PRWEB) , ... March 29, 2017 , ... ... now receive FASTBRACES® in Carnegie, OK, from Dr. Jamie Cameron, with ... straighten teeth efficiently, compared to traditional orthodontic treatment. Depending on each patient’s case, ...
(Date:3/29/2017)... ... March 29, 2017 , ... How big ... outpatient facilities, and who are the most active developers? , In the ... Healthcare Real Estate Insights (HREI) found that outpatient medical real estate development projects ...
(Date:3/29/2017)... ... 2017 , ... An inventor from Raynham, Mass., knows the ... conjunction with my braces always rubbed against the inside of my cheeks, causing ... problem." The O.B.S. was the result of his brainstorming. , This patent-pending invention ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... , March 29, 2017 Avelas Biosciences, Inc., a clinical ... through treatment, today announced that Carmine N. Stengone , president ... at the Needham & Company 16 th Annual Healthcare Conference ... PDT) at the Westin Grand Central Hotel in New ... ...
(Date:3/29/2017)... EAST HANOVER, N.J. , March 29, 2017 ... and Drug Administration (FDA) has accepted the company,s ... review for CTL019 (tisagenlecleucel-T), an investigational chimeric antigen ... refractory (r/r) pediatric and young adult patients with ... first BLA submission by Novartis for a CAR-T. ...
(Date:3/29/2017)... March 29, 2017 Today, CVS Health officials (NYSE: ... Reynolds , Department of Public Health Director Gerd Clabaugh ... Lukan in announcing the availability of the opioid overdose-reversal ... in Iowa.  CVS Health has established a standing order with ... Pharmacy to expand access to the medication in the state.   ...
Breaking Medicine Technology: