Navigation Links
Lean patients with fatty liver disease have higher mortality rate
Date:5/4/2014

Chicago, IL (May 4, 2014) Despite being of a healthier weight, lean patients with nonalcoholic fatty liver disease (NAFLD) have a higher overall mortality rate than patients with NAFLD who are overweight or obese, according to new research presented today at Digestive Disease Week (DDW). In addition to finding higher mortality rates, an international team of researchers found that lean patients [a body mass index (BMI) less than 25] with NAFLD were more likely to be male, non-Caucasian and to have lower rates of chronic conditions, such as diabetes and hypertension.

"Our comparison of lean patients and their overweight or obese counterparts gives us clues about risk factors for this disease that go beyond a person's weight," said Paul Angulo, MD, section chief of hepatology in the division of digestive diseases and nutrition at the University of Kentucky Medical Center. "These findings have implications both for future research and for current standards of care. We must not assume that patients of relatively healthy weight can't have fatty liver disease."

The retrospective study is the first of its kind in detailing the characteristics of a large number of lean patients with NAFLD. The study examined more than 20 years' worth of clinical and laboratory data of more than 1,000 patients with biopsy-confirmed NAFLD. Lean patients had an average BMI of 23 and the non-lean group had an average BMI of 33.

The lean group had significantly less insulin resistance as well as lower levels of a liver enzyme called alanine aminotransferase (ALT) that correlates with liver damage. And while lean patients had a lower degree of fatty deposits on the liver and less advanced fibrosis, these patients showed more severe inflammation of the liver.

Of the 1,090 patients, liver biopsy was done before 2005 in 483 patients. In this subgroup, nine of the 32 (28 percent) lean patients died compared to 62 of the 451 (14 percent) overweight or obese patients. In examining the specific cause of mortality, researchers did not find any differences between the two groups.

"About 30 percent of the U.S. population suffers from NAFLD, and the prevalence of this condition is increasing. Although we often associate fatty liver disease with obese patients, these results suggest that possible signs of liver disease secondary to NAFLD in lean patients should be taken very seriously," said Dr. Angulo.

Dr. Angulo and his team plan to expand on their findings about this specific patient population by examining data beyond BMI, including fat distribution and differences in cell signaling proteins, such as cytokine and adipokine profiles. They also plan to include patients who have not yet had a liver biopsy.

Dr. Paul Angulo will present data from the study "Characteristics and long-term prognosis of lean patients with nonalcoholic fatty liver disease," abstract 379, on Sunday, May 4, at 2:45 p.m. CT, in room S405A of McCormick Place. For more information about featured studies, as well as a schedule of availability for featured researchers, please visit http://www.ddw.org/press.


'/>"/>

Contact: Aimee Frank
newsroom@gastro.org
301-941-2620
Digestive Disease Week
Source:Eurekalert

Related medicine news :

1. Higher-spending hospitals have fewer deaths for emergency patients
2. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
3. Vaccine yielded encouraging long-term survival rates in certain patients with NSCLC
4. Study finds doctors have exaggerated fears when starting patients on insulin
5. Diagnostic Scans Tied to Radiation Risk for Gastro Patients
6. Predictors identified for rehospitalization among post-acute stroke patients
7. Pulse pressure elevation could presage cerebrovascular disease in Alzheimers patients
8. Breast cancer patients suffer treatment-related side effects long after completing care
9. Heart failure patients with diabetes may benefit from higher glucose levels
10. Gastro Woes Often Strike Rheumatoid Arthritis Patients
11. Short Walks May Ease Fatigue in Pancreatic Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/16/2017)... ... August 16, 2017 , ... ... through affiliations and de novo development, today announced Cumberland Skin Surgery and ... Skin Surgery and Dermatology, with offices in both Hermitage and Lebanon, Tennessee, provides ...
(Date:8/16/2017)... Kansas City, KS (PRWEB) , ... August 16, ... ... announced the latest beneficiary of their recently launched community enrichment program. Partnering once ... fundraising for the KC Superstar competition to help find the area’s very own ...
(Date:8/16/2017)... ... 16, 2017 , ... Maury Regional Health has announced a large-scale adoption of ... AccuVein devices, Maury Regional Medical Center is making vein visualization part of their standard ... stick and more importantly, helps our staff members locate a vein that will provide ...
(Date:8/16/2017)... ... 16, 2017 , ... The Southeastern Telehealth Resource Center at ... renewing its funding from the Health Resources and Services Administration (HRSA), part of ... fourth time the HRSA administration has renewed its financial support to GPT since ...
(Date:8/16/2017)... ... ... Paul Vitenas, MD, FACS , is honored to announce that he has ... nation’s top physicians, in a variety of specialties. This marks the fourth year in ... coveted ranking. , Castle Connolly is the nation’s trusted provider of information on the ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... HOUSTON , Aug. 15, 2017   Mostyn Law ... in Houston, Texas . The Mostyn Law ... the past 2 years. That is why Mostyn Law ... Texas to show its appreciation. Blood supplies ... to fall 5% short of hospital needs in August. That is ...
(Date:8/15/2017)... Aug. 15, 2017 Diplomat Pharmacy, Inc. (NYSE: ... Michigan residents. Naloxone is ... retail pharmacy, G-3320 Beecher Road. ... Food and Drug Administration, is intended to block or ... breathing, and loss of consciousness. The medication is often ...
(Date:8/15/2017)... , Aug. 15, 2017  Axium Pharmaceuticals Inc., the creator of ... to be in the beginning stages of an IPO. ... epilepsy medications with the average cost of a prescription epilepsy drug being ... AXIUM ... Another staggering figure is the fact that ...
Breaking Medicine Technology: