Navigation Links
Leaky gut -- A source of non-AIDS complications in HIV-positive patients
Date:9/3/2014

the tight junctions correlated with increased microbial translocation and a greater level of inflammation throughout the body," Levine said. "This finding provides evidence that a defect in the gut wall allowing bacterial products to leak out is the likely source of immune activation and subsequent inflammation. Basically, we found with this group of HIV-positive patients that the gut is leaky and why."

These findings provide a clear target for clinical intervention repair the molecular and structural epithelial leakiness in the tight junctions of the colon. However, critical questions must be resolved: Is the disruption caused by an HIV infection, the remaining HIV virus itself, antiretroviral drugs or all three combined to play a role in weakened tight junctions? What changes in epithelial cells might cause decreased activity of the tight junctions? Will repairs to the tight junction lead to stronger barrier function and reduced gut leakiness? Will reduced gut leakiness result in less systemic inflammation and therefore cause less cardiovascular, neurodegenerative, chronic kidney and metabolic diseases, and cancer in the virally suppressed HIV-positive patient?

"The key observation here is that virally suppressed HIV-positive patients have an important molecular and tissue defect a leaky gut," Levine said. "Thus, the clinical implication is quite clear. We will need additional supplemental therapeutic approaches to repair this damaged epithelium in the colon."


'/>"/>

Contact: Jeannette Spalding
jeannette.spalding@case.edu
216-368-3004
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Leaky Gut Cure Review Reveals Unique Method to Stop Chronic Symptoms
2. Leaky Gut Cure Program Review Reveals Karen Brimeyer’s Plan For Treating Leaky Gut Syndrome – Vkool.com
3. Leaky Gut Cure Review Reveals Karen Brimeyer’s Natural Way to Heal Leaky Gut
4. Why inflammation leads to a leaky blood-brain barrier: MicroRNA-155
5. Plugging leaky blood vessels to save vision
6. Natural Leaky Gut Cure Review Reveals Effective Home Treatment
7. Karen Brimeyer’s Natural Leaky Gut Cure Review and Diet Plan Revealed by Daily Gossip
8. NutriGold’s Organic Wholefood-Sourced Vitamin C Gets ConsumerLab’s Seal of Approval
9. Home Made Energy Review Exposes Simple Method to Access Alternative Energy Sources
10. Top Three Open Source Design Concepts that Rethink Health from Involution Studios
11. ALS Insights Launched as Web Resource of Interviews and Information
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... The report “CountryFocus: Healthcare, Regulatory and Reimbursement Landscape ... and analysis of the healthcare, regulatory and reimbursement landscape ... 2013 amounted to 316.1 million, having grown at a ... The country’s increasingly elderly population and corresponding increase in ... the growth of the pharmaceutical market, which was worth ...
(Date:3/27/2015)... 27, 2015 California’s ongoing worst ever ... Boston and the United States Northeast, are both manifestations ... global atmosphere is creating changes in the atmosphere’s “energy ... and former NASA researcher, speaking on the Sharon Kleyne ... not only a warmer and dryer global climate but ...
(Date:3/27/2015)... 27, 2015 Approximately 300 advocates ... Kids Coalition Lobby Day to lobby for physical ... Program (SHIP). Everlast Climbing was especially interested ... SF343/HF498 which would strengthen physical education programs by ... and other measures to strengthen physical education in ...
(Date:3/27/2015)... (PRWEB) March 27, 2015 Smile Brands ... providers of business support services to dental groups in ... an affiliated Castle Dental office in Hendersonville, ... Hendersonville, TN 37075, this new Castle Dental office provides ... receive the latest in comprehensive, quality dental care. Hendersonville ...
(Date:3/27/2015)... In light of two lawsuits that ... District Court, District of Massachusetts; and case number 2:15-cv-00709PD, ... Pennsylvania), the San Diego personal injury lawyers of The ... that they are available to investigate potential birth ... prescribed Zofran while pregnant and who gave birth to ...
Breaking Medicine News(10 mins):Health News:US Pharmaceutical Market worth $548.4 billion by 2020 Says a New Report Available at RnRMarketResearch.com 2Health News:US Pharmaceutical Market worth $548.4 billion by 2020 Says a New Report Available at RnRMarketResearch.com 3Health News:US Pharmaceutical Market worth $548.4 billion by 2020 Says a New Report Available at RnRMarketResearch.com 4Health News:California Drought, Boston Blizzards Both Attributed to Global Climate Change Reports Climatologist to Fresh Water Advocate 2Health News:California Drought, Boston Blizzards Both Attributed to Global Climate Change Reports Climatologist to Fresh Water Advocate 3Health News:Everlast Climbing Advocates to Strengthen Physical Education in Minnesota Schools 2Health News:Castle Dental® Opens Its First Dental Office in Hendersonville, TN 2Health News:Castle Dental® Opens Its First Dental Office in Hendersonville, TN 3Health News:The Law Office of Melinda J. Helbock, A.P.C. Announces That It Is Now Accepting Case Reviews for Potential Zofran Birth Defect Lawsuits 2
... has been shown that the drug Rimonabant (Acomplia) ... patients keep weight off // . Supplementation with 20 ... decrease in body weight and waist circumference -- a ... HDL (good) cholesterol, triglycerides, and the prevalence of metabolic ...
... cholesterol (“bad” cholesterol) to below 100 milligrams per deciliter ... is safe and results in fewer cardiovascular events. ... took 10 milligrams of atorvastatin (Lipitor) a day to ... deciliter a day or lower. Then, half of the ...
... in Spain has focused on the increasing incidence of ... associated with an increased risk of cancer in the ... been proven to have disastrous effects on the fetus ... complications such as extra uterine pregnancy, or pregnancy resulting ...
... increased recommendations for daily calcium intake, largely from dairy ... promote healthy bones and prevent osteoporosis. But a report ... milk or other dairy products was not necessarily the ... at least 400 milligrams per day. ,Other ways ...
... Most viruses, including herpes, cause both active infections and also ... no immediate infection // but can strike again whenever resistance ... those infected. ,Based on findings of a recent study ... as a treatment for a form of the herpes virus ...
... from the bone-thinning disease osteoporosis may also be at ... in which people have a difficult time digesting wheat ... bone mineral density, or BMD, among patients with both ... thinning bones, but little study exists to suggest if ...
Cached Medicine News:
(Date:3/26/2015)... 2015  The Burzynski Research Institute, Inc. (BRI) announced ... by the Department of Surgery at Kurume University ... have been published. The study, a randomized non-blinded ... as post-operative adjuvant therapy with and without Antineoplastons ... A total of 65 patients, ...
(Date:3/26/2015)... March 26, 2015  OncoGenex Pharmaceuticals, Inc. (NASDAQ: ... clinical developments and announced fourth quarter and year ... Developments and Anticipated Near-term MilestonesCustirsen , ... to negotiate the termination of their collaboration and ... final termination agreement are ongoing. , Two ...
(Date:3/26/2015)... 2015 Over-the-counter healthcare costs can be ... a new survey of store brand over-the-counter products ... cold to diabetes, can offer significant savings for ... the Private Label Manufacturers Association, assembled a market ... those essential for treatment of pre-diabetes and diabetes. ...
Breaking Medicine Technology:OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 2OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 3OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 4OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 5OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 6OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 7OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 8Consumers can keep over-the-counter medicine affordable by using store brands 2
... 2011 Arecor Limited has entered ... Company to assess Arecor,s advanced protein formulation technologies ... biological-based drugs.  Under this agreement, Arecor will develop ... protein and peptide drug candidates developed by Lilly.  In ...
... 2011 For 64 years, The Elko ... northeast Nevada town of roughly 20,000, providing family-oriented ... pediatrics, surgical procedures and the treatment of ... latest in medical technology and equipment toward ...
Cached Medicine Technology:Arecor Forms Collaboration With Lilly to Develop Advanced Formulations of Protein Therapeutics 2MedInformatix' Practice Management and Electronic Medical Records Dramatically Speed Family Practice's Receivables, Reduce Operating Costs 2MedInformatix' Practice Management and Electronic Medical Records Dramatically Speed Family Practice's Receivables, Reduce Operating Costs 3
The microprocessor-controlled, Norm-O-Temp® total body hyperthermia water system provides effective heat therapy at less than half the cost of a hyper-hypothermia system....
The control unit manage patient temperatures during long complex surgical procedures to help achieve optimal clinical outcomes....
... T5002 has it's temperature set by ... by pressing a button. A green ... and a flashing amber LED indicates ... temperature. A red LED and an ...
The Cocoon Convective Warming Machine is lightweight, compact and easy to use....
Medicine Products: