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Leaky blood vessels open up nerve cells to toxic assault in Lou Gehrig's disease
Date:4/7/2008

o far, the disease progresses exactly in inherited forms and forms that are not inherited.

The vascular system is crucial to health its how oxygen and other nutrients are delivered to cells, and how toxins are removed, said Zlokovic, who is professor of Neurosurgery and Neurology and director of the Center for Neurodegenerative and Vascular Brain Disorders. Any damage to the vascular system is a serious threat to the organism. Its clear now that the vascular system is certainly involved in the development of ALS.

Zlokovic first began doing research on the disease in 2004, when a former classmate from medical school who had been diagnosed with ALS and was looking for new treatments contacted him. By the time his friend died two years later, Zlokovic was well underway in studies investigating the possible role of the vascular system.

During the last 15 years, Zlokovic has pioneered the view that the vascular system plays a central role in many neurodegenerative diseases. He has found that a breakdown in the barriers between the blood and the central nervous system may be at the root of diseases like Alzheimers. In January, Zlokovic reviewed the evidence for involvement of the barrier in diseases like Alzheimers, ALS, and multiple sclerosis in a 24-page review in Neuron.


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Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

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