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Leading HIV researchers to collaborate on vaccine development
Date:4/15/2008

do not develop AIDS

  • Development of standardized methods to sample tissues from mucosal surfaces in the body, where HIV initially establishes infection.

    Investigators supported by both organizations are especially interested in further understanding what happens in the very earliest post-infection stage of HIV infection, especially within the bodys T cells, a class of white blood cells that normally fight off foreign invaders like bacteria and viruses. One of the goals of this work will be to identify any genetic variations linked to the strength of the immune response at the site of initial infection. CHAVI and IAVI hope that by sharing samples, reagents, databases and laboratories and by launching parallel studies, they will be able to speed up discoveries about this critical phase of the disease.

    Each partner to the agreement will contribute unique resources. For example, CHAVI supports high-throughput sequencing technology that can reveal tiny mutations in the ever-changing virus, but which require large numbers of HIV samples in order to identify variations that are meaningful. Through its network of clinical research centers and immunological laboratories around the world, IAVI and its partners have developed a number of tests to evaluate human immune responses to HIV and to potential vaccine candidates, information that can help researchers refine and improve any candidate that shows promise. By pooling technologies, protocols and access to samples, the IAVI/CHAVI collaboration aims to extract maximum information to help accelerate the development of a safe and effective AIDS vaccine.

    As an African clinical investigator and the leader of the scientific steering committee that oversees the IAVI-supported study of acute HIV infection, I am pleased to be collaborating with IAVI and CHAVI. It is critical to investigate the influence of genetic diversity of HIV as well as the variety of human immune responses to HIV
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  • Contact: Michelle Gailiun
    michelle.gailiun@duke.edu
    919-684-4148
    Duke University Medical Center
    Source:Eurekalert

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