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Leading HIV researchers to collaborate on vaccine development
Date:4/15/2008

DURHAM, NC, and NEW YORK, NY Two global research organizations dedicated to designing a vaccine against HIV the International AIDS Vaccine Initiative (IAVI), and the Center for HIV/AIDS Vaccine Immunology (CHAVI) have signed an agreement to work together to address major biological questions that have slowed development of a safe, effective and affordable AIDS vaccine.

Solving the HIV vaccine puzzle is a scientific challenge that can only be solved through fundamental and applied research, collaboration and transparency. The work that will be done by IAVI, CHAVI and their networks of partners will rapidly enhance our understanding of HIV and help lay the groundwork for new vaccine approaches, says Dr. Barton Haynes, CHAVI director and professor of medicine at Duke University Medical Center.

There are approximately 33 million people around the world living with HIV, the virus that causes AIDS. Scientists have tested multiple vaccine candidates in early phase trials, but only two have been fully tested in efficacy trials and neither has been found effective in preventing HIV infection or lowering the viral load in patients who subsequently encountered HIV and became infected.

We are committed to the discovery of an effective vaccine, particularly for regions hardest hit by the epidemic, says Dr. Wayne Koff, senior vice president of research and development at IAVI. We are hoping that the synergy of shared investigation will yield insight into novel solutions that will advance AIDS vaccine discovery.

The shared CHAVI/IAVI research mission will focus on four key areas that will help inform the design of new and improved vaccine candidates:

  • Identification and full-length genetic sequencing of newly transmitted viruses

  • Clarifying the impact of human genetics on the control of HIV infection

  • Collaborative immunological studies that could shed light on why some people who are exposed to HIV
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Contact: Michelle Gailiun
michelle.gailiun@duke.edu
919-684-4148
Duke University Medical Center
Source:Eurekalert

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